Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00088 | Target Info | |||
| Target Name | GPI transamidase component PIG-U (PIGU) | ||||
| Synonyms | UNQ3055/PRO9875; Phosphatidylinositol-glycan biosynthesis, class U protein; PIGU; PIG-U; Cell division cycle protein 91-like 1; CDC91L1; CDC91-like 1 protein | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | PIGU | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: [2-[[(2~{R})-2-hexanoyloxy-3-[(~{E})-hex-3-enoxy]propoxy]-oxidanyl-phosphoryl]oxy-3,4,5,6-tetrakis(oxidanyl)phenyl] (2~{E},4~{E})-hepta-2,4-dienoate | Ligand Info | |||||
| Structure Description | Structure of a human glycosylphosphatidylinositol (GPI) transamidase | PDB:7W72 | ||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [1] |
| PDB Sequence |
MAAPLVLVLV
10 VAVTVRAALF20 RSSLAEFISE30 RVEVVSPLSS40 WKRVVEGLSL50 LDLGVSPYSG 60 AVFHETPLII70 YLFHFLIDYA80 ELVFMITDAL90 TAIALYFAIQ100 DFNKVVFKKQ 110 KLLLELDQYA120 PDVAELIRTP130 MEMRYIPLKV140 ALFYLLNPYT150 ILSCVAKSTC 160 AINNTLIAFF170 ILTTIKGSAF180 LSAIFLALAT190 YQSLYPLTLF200 VPGLLYLLQR 210 QYIPVKMKSK220 AFWIFSWEYA230 MMYVGSLVVI240 ICLSFFLLSS250 WDFIPAVYGF 260 ILSVPDLTPN270 IGLFWYFFAE280 MFEHFSLFFV290 CVFQINVFFY300 TIPLAIKLKE 310 HPIFFMFIQI320 AVIAIFKSYP330 TVGDVALYMA340 FFPVWNHLYR350 FLRNIFVLTC 360 IIIVCSLLFP370 VLWHLWIYAG380 SANSNFFYAI390 TLTFNVGQIL400 LISDYFYAFL 410 RREYYLTHGL420
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of human glycosylphosphatidylinositol transamidase. Nat Struct Mol Biol. 2022 Mar;29(3):203-209. | ||||
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