Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99993 | Target Info | |||
| Target Name | HUMAN vascular endothelial growth factor (VEGF) | ||||
| Synonyms |
Vascular endothelial cell growth factor
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| Biochemical Class | Growth factor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 18 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
US8598210, Table XV, 2
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Patented | Compound Info | ||
| Synonyms |
US8722895, 2: {[5-(4-Chloro-phenyl)-3-hydroxy-pyridine- 2-carbonyl]-amino}-acetic acid methyl ester; SCHEMBL1921358; CHEMBL3646213; BDBM107696; US8598210, Table XV, 2
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| Activity | Vascular endothelial growth factor A |
EC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
US8598210, Table XV, 5
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Patented | Compound Info | ||
| Synonyms |
US8722895, 5: [(3-Hydroxy-4'-methyl-biphenyl-4- carbonyl)-amino]-acetic acid; SCHEMBL1921403; CHEMBL3646216; BDBM107699; US8598210, Table XV, 5
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| Activity | Vascular endothelial growth factor A |
EC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
US8722895, 21: {[5-(3-Carbamoyl-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1921203; CHEMBL3646231; BDBM107715; US8598210, Table XV, 21; methyl 2-[[5-(3-carbamoylphenyl)-3-hydroxypyridine-2-carbonyl]amino]acetate
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| Activity | Vascular endothelial growth factor A |
EC50 = 50100 nM
|
[1] | ||
| Compound Name |
1-Benzyl-3-hydroxy-4-[(2-methylsulfanylethylamino)methyl]pyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL273704; CHEMBL3649595; BDBM102340; US8536181, C33
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| Activity | Vascular endothelial growth factor A |
IC50 = 53000 nM
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[2] | ||
| Compound Name |
1-Benzyl-3-hydroxy-4-[[(2R)-2-(2-hydroxyethyl)pyrrolidin-1-yl]methyl]pyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3652868; SCHEMBL12598821; BDBM126621; US8778412, B5
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| Activity | Vascular endothelial growth factor A |
IC50 = 53000 nM
|
[2] | ||
| Compound Name |
1-Benzyl-3-hydroxy-4-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]methyl]pyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1772403; CHEMBL3674747; BDBM102339; US8536181, B5
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| Activity | Vascular endothelial growth factor A |
IC50 = 53000 nM
|
[3] | ||
| Compound Name |
3-[(1-Benzyl-3-hydroxy-2-oxopyridin-4-yl)methylamino]azepan-2-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL273303; CHEMBL3649597; BDBM102342; US8536181, C19
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| Activity | Vascular endothelial growth factor A |
IC50 = 62900 nM
|
[2] | ||
| Compound Name |
1-Benzyl-4-[[4-(6-chloropyridazin-3-yl)piperazin-1-yl]methyl]-3-hydroxypyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL273236; CHEMBL3649596; BDBM102341; US8536181, B14
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| Activity | Vascular endothelial growth factor A |
IC50 = 78000 nM
|
[2] | ||
| Compound Name |
Methyl 2-[[3-hydroxy-5-(4-isocyanophenyl)pyridine-2-carbonyl]amino]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3646214; SCHEMBL12978736
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| Activity | Vascular endothelial growth factor A |
EC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
({3-Hydroxy-5-[3-(pyrrolidine-1-carbonyl)-phenyl]-pyridine-2-carbonyl}-amino)-acetic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1922994; CHEMBL3646232; BDBM107716; US8598210, Table XV, 22; methyl 2-[[3-hydroxy-5-[3-(pyrrolidine-1-carbonyl)phenyl]pyridine-2-carbonyl]amino]acetate
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| Activity | Vascular endothelial growth factor A |
EC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
2-[[3-Hydroxy-5-(3-isocyanophenyl)pyridine-2-carbonyl]amino]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3646230; SCHEMBL12978699
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| Activity | Vascular endothelial growth factor A |
EC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
US8722895, 15: {[5-(4-Isopropoxyphenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
US8722895, 15: {[5-(4-Isopropoxyphenyl)-3- hydroxypyridine-2-carbonyl]amino}-acetic acid; SCHEMBL1921336; CHEMBL3646225; BDBM107709; US8598210, Table XV, 15; 2-[[3-hydroxy-5-(4-propan-2-yloxyphenyl)pyridine-2-carbonyl]amino]acetic acid
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| Activity | Vascular endothelial growth factor A |
EC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
1-[(3-Chlorophenyl)methyl]-3-hydroxypyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1770473; CHEMBL3649605; BDBM102351; ZINC96173253; US8536181, F2
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| Activity | Vascular endothelial growth factor A |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
US8722895, 23: ({3-Hydroxy-5-[3-(pyrrolidine-1-carbonyl)phenyl]-pyridine-2-carbonyl}amino)-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1920932; CHEMBL3646233; BDBM107717; US8598210, Table XV, 23
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| Activity | Vascular endothelial growth factor A |
EC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
US8722895, 24: ({3-Hydroxy-5-[3-(2H-tetrazol-5-yl)phenyl]-pyridine-2-carbonyl}-amino)-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
US8722895, 24: ({3-Hydroxy-5-[3-(2H-tetrazol-5-yl)phenyl]- pyridine-2-carbonyl}-amino)-acetic acid; SCHEMBL1921228; CHEMBL3646234; BDBM107718; BDBM301825; US8598210, Table XV, 24; US9598370, Example 00149
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| Activity | Vascular endothelial growth factor A |
EC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
US8722895, 14: {[5-(4-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
US8722895, 14: {[5-(4-Chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid; SCHEMBL1921949; CHEMBL3646224; BDBM107708; US8598210, Table XV, 14; 2-[[5-(4-fluorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
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| Activity | Vascular endothelial growth factor A |
EC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
Methyl 2-[[3-hydroxy-5-(3-isocyanophenyl)pyridine-2-carbonyl]amino]acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3646228; SCHEMBL12978648
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| Activity | Vascular endothelial growth factor A |
EC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
US8722895, 19: ({3-Hydroxy-5-[3-(2H-tetrazol-5-yl)-phenyl]-pyridine-2-carbonyl}-amino)-acetic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1921448; CHEMBL3646229; BDBM107713; BDBM301820; US8598210, Table XV, 19; US9598370, Example 00144
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| Activity | Vascular endothelial growth factor A |
EC50 ~ 100000 nM
|
[1] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | US patent application no. 8598210B2, Prolyl hydroxylase inhibitors and methods of use | ||||
| REF 2 | US patent application no. 9278930B2, Methods for increasing the stabilization of hypoxia inducible factor-alpha | ||||
| REF 3 | US patent application no. 8536181B2, Prolyl hydroxylase inhibitors | ||||
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