Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99989 | Target Info | |||
| Target Name | Casein kinase I epsilon (CSNK1E) | ||||
| Synonyms |
Casein kinase I isoform epsilon; CKIe; CKI-epsilon
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|
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| Target Type | Successful Target | ||||
| Gene Name | CSNK1E | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 32 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[4-[[5-(1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]-5-methoxybenzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391118; SCHEMBL14603900; BDBM50435039
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|
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
4-[4-[[5-(1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064515; SCHEMBL16944474; BDBM50389080
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| Activity |
IC50 = 60000 nM
|
[2] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(3,5-difluorophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391117; BDBM50435038
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| Activity |
IC50 = 80000 nM
|
[1] | |||
| Compound Name |
2-[4-[[5-[3-(Methoxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064537; SCHEMBL14604035
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
CID 71578744
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391101; BDBM50435025; N-[4-[5-[(3-cyanophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]pyridin-2-yl]acetamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[[4-(4-Methoxyphenyl)phenyl]methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391131; SCHEMBL14604069; BDBM50435029
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[[4-(3,5-Difluorophenyl)phenyl]methylsulfanyl]-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391124; SCHEMBL14604425; BDBM50435018
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[4-[5-[[4-(2-Cyanophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazol-2-yl]pyridin-2-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391102; BDBM50435024
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391132; SCHEMBL14604396; BDBM50435031
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[(4-Phenylphenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391099; SCHEMBL14604409; BDBM50435027; AKOS000905896
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064536; SCHEMBL14604399; BDBM50389082
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[4-(5-Benzylsulfanyl-1,3,4-oxadiazol-2-yl)pyridin-2-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391100; BDBM50435026
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(2-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391129; BDBM50435023
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[[4-(2-Nitrophenyl)phenyl]methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391133; BDBM50435032
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2390958; SCHEMBL14604141; BDBM50435030
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]-5-methoxybenzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391125; SCHEMBL14604165; BDBM50435019
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(3-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391120; BDBM50435033
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(2H-1,3-Benzodioxol-5-yl)-5-[({[1,1'-biphenyl]-4-yl}methyl)sulfanyl]-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064531; SCHEMBL14604056; ZINC5019100; BDBM50389086; AKOS000875105; MCULE-8962558919; Z19456538
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(2-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391122; BDBM50435035
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[4-[[5-[(3R)-3-(Methoxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064538; SCHEMBL14603965; BDBM50389084
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(4-methoxyphenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391126; SCHEMBL14604054; BDBM50435020
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[4-[[5-[(3S)-3-(Methoxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064539; SCHEMBL14603830; BDBM50389078
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-Fluoro-2-[4-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391098; BDBM50435028
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064534; SCHEMBL14604288; BDBM50389081
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(3-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391128; SCHEMBL14603927; BDBM50435021
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[4-[[5-(1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391121; BDBM50435034
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Methyl 4-[[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064520; BDBM50389085
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]-5-fluorobenzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064535; SCHEMBL14604060; BDBM50389083
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391130; SCHEMBL14603849; BDBM50435022
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[(4-phenylphenyl)methylsulfanyl]-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391123; SCHEMBL14604095; BDBM50435036
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4'-({[5-(2H-1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}methyl)-[1,1'-biphenyl]-2-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064533; BDBM50389087; ZINC22415373; AKOS033887643; MCULE-8760820046; Z237995644
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391127; SCHEMBL14603718; BDBM50435037
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
AR-A014418
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|
Patented | Compound Info | ||
| Synonyms |
487021-52-3; GSK-3beta Inhibitor VIII; 1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea; A Inhibitor VIII; N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA; UNII-87KSH90Q6D; AR-AO 14418; SN 4521; AR-A 014418; CHEMBL259850; 87KSH90Q6D; N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea; AK175829; C12H12N4O4S; N-(4-Methoxybenzyl)-N& -(5-nitro-1,3-thiazol-2-yl)urea; AR 014418; GSK 3be
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|
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| Activity |
IC50 > 100000000 nM
|
[3] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]-3-[6-(2H-tetrazol-5-yl)-1,3-benzothiazol-2-yl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824332; BDBM50352494
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|
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| Activity |
IC50 = 15300000 nM
|
[3] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]-3-[4-(2H-tetrazol-5-yl)pyridin-2-yl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824334; BDBM50352493
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|
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| Activity |
IC50 > 100000000 nM
|
[3] | |||
| Compound Name |
1-(4-Cyanopyridin-2-yl)-3-[(4-methoxyphenyl)methyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824539; BDBM50352491
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|
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| Activity |
IC50 > 100000000 nM
|
[3] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]-3-(6-nitro-1,3-benzothiazol-2-yl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824540; BDBM50352492
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|
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| Activity |
IC50 > 100000000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-based optimization of oxadiazole-based GSK-3 inhibitors. Eur J Med Chem. 2013 Mar;61:26-40. | ||||
| REF 2 | Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3alpha. J Med Chem. 2012 May 10;55(9):4407-24. | ||||
| REF 3 | Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5610-5. | ||||
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