Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99840 | Target Info | |||
| Target Name | Gamma-secretase (GS) | ||||
| Synonyms |
Presenilin-stabilization factor-like; PSFL; Aph-1beta
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|
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| Target Type | Successful Target | ||||
| Gene Name | APH1A; APH1B; NCSTN; PSENEN; PSEN1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 80 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4204874
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50452829
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
CID 59472544
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3608385; SCHEMBL3052100; BDBM50114807
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-[6-(5-Tert-butyl-2-methylanilino)-2-[4-(4-methoxyphenyl)-3,3-dimethylpiperazin-1-yl]pyrimidin-4-yl]oxy-2-methylbutan-2-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589658; BDBM50481576
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(5-Tert-butyl-2-methylphenyl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]-7-methylpurin-6-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089530; SCHEMBL2526744; BDBM50482061
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(5-Tert-butyl-2-methylphenyl)-2-[4-(4-methoxyphenyl)-3,3-dimethylpiperazin-1-yl]-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]pyrimidin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589855; BDBM50481574
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-[2-[4-Chloro-2-(trifluoromethyl)phenoxy]ethyl]-7-(4-methyl-1H-imidazole-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127906; SCHEMBL12804655; BDBM50448735
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-[(3R)-5-Chloro-2,3-dihydro-1-benzofuran-3-yl]-3-methoxy-4-(4-methylimidazol-1-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2018348
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
1-[(4-Tert-butylphenyl)methyl]-4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1818829; SCHEMBL3053178; BDBM50350785
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|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
2-[4-[[4-[3-Methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]methyl]phenyl]-1,3-benzoxazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1818837; SCHEMBL3056822; BDBM50350784
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|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N-[(3R)-5-Chloro-4-fluoro-2,3-dihydro-1-benzofuran-3-yl]-6-methoxy-5-(4-methylimidazol-1-yl)pyridine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2018331; BDBM50380809
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(3S)-6-Fluoro-3-[4-[3-fluoro-2-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]-1-(2,2,2-trifluoroethyl)-4,5-dihydro-3H-1-benzazepin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3609755; BDBM50114837
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|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
CID 46884679
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092725; SCHEMBL2519820; BDBM50482056
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|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(5-Tert-butyl-2-methylphenyl)-6-methoxy-2-[4-(4-methoxyphenyl)-3,3-dimethylpiperazin-1-yl]pyrimidin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591595; SCHEMBL3019415; BDBM50481571
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|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
CID 59472470
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3609759; SCHEMBL3059583; BDBM50114845
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|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-Chloro-2-ethyl-9-octylcarbazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812396; BDBM50484100
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|
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| Activity |
EC50 = 50000 nM
|
[8] | |||
| Compound Name |
N-(5-Tert-butyl-2-methylphenyl)-2-[4-(4-methoxyphenyl)-3,3-dimethylpiperazin-1-yl]-7-methylpurin-6-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091494; SCHEMBL1551728; BDBM50482062
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|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
CID 25025157
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589905; SCHEMBL3029333; BDBM50481572
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
8-[(E)-4-(4-Methyl-1H-imidazole-1-yl)-3-methoxybenzylidene]-4alpha-(3,4,5-trifluorophenyl)-3,4,5,6,7,8-hexahydro-1,4a-diaza-2-oxanaphthalene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1950535; SCHEMBL15576407; BDBM50364034
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|
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
2-{2-[4-Fluoro-2-(trifluoromethyl)phenoxy]ethyl}-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127905; SCHEMBL12804467; BDBM50448736
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Chembl4209756
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50452828
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|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
[(3S,8E)-3-(4-Fluorophenyl)-8-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]-6,7-dihydro-5H-[1,2,4]oxadiazolo[4,3-a]pyridin-3-yl]methanol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1950434; SCHEMBL7907169; BDBM50364031
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|
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
CID 46229901
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589505; SCHEMBL3012135; BDBM50481570
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[(1S)-1-(4-Fluorophenyl)ethyl]-5-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-1,3-thiazol-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808603; BDBM50484069
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|
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| Activity |
IC50 = 50118.72 nM
|
[10] | |||
| Compound Name |
5-[3-(Dimethylamino)-4-(4-methylimidazol-1-yl)phenyl]-N-[(1S)-1-(4-fluorophenyl)ethyl]pyridin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808606; BDBM50484084
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|
||||
| Activity |
IC50 = 50118.72 nM
|
[10] | |||
| Compound Name |
Sodium;2-[(2S,4R)-1-[(R)-cyclopropyl-[6-(trifluoromethyl)pyridin-3-yl]methyl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl]acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598707; BDBM50481791
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|
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| Activity |
IC50 = 50118.72 nM
|
[11] | |||
| Compound Name |
Sulindac sulfide
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|
Investigative | Compound Info | ||
| Synonyms |
(Z)-Sulindac sulfide; UNII-6UVA8S2DEY; 6UVA8S2DEY; CHEMBL18797; (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid; NCGC00161601-01; DSSTox_CID_29004; DSSTox_RID_83269; DSSTox_GSID_49078; MFCD00869764; Sulindac sulphide; Sulindac sulfide, (Z)-; 5-Fluoro-2-methyl-1-(p-methylthiobenzylidene)-3-indenyl acetic acid; EINECS 256-403-9; UPCMLD-DP020; Sulindac Related Compound C; SCHEMBL2586650; DTXSID0049078; UPCMLD-DP020:001; cid_5352624; 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-; HY-B1786; Tox21_113636; 5-fluoro-2-methyl-1-(4-methylthiobenzylidene)inden-3-ylacetic acid; BDBM50110164; NSC747692; ZINC12404515; AKOS015965586; Tox21_113636_1; CCG-208108; NSC-747692; NCGC00161601-02; AC-20512; Sulindac Sulfide - CAS 32004-67-4; Sulindac sulfide, >=98% (HPLC), solid; UNM-0000306137; CS-0013817; 004S674; SR-01000944868; SR-01000944868-1; BRD-K76525302-001-01-3; Q27145288; (Z)-5-fluoro-2-methyl-1-(4-methylthiobenzylidene) inden-3-ylacetic acid; (Z)-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)inden-3-ylacetic acid; (Z)-5-fluoro-2-methyl-1-(4-methythiobenzylidene)-3-indenylacetic acid; 5-Fluoro-2-methyl-1-(4-methylthiobenzylidene)inden-3-yl acetic acid; [6-Fluoro-2-methyl-3-(4-methylsulfanyl-benzylidene)-3H-inden-1-yl]-acetic acid; 2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-methyl-3H-inden-1-yl)acetic acid
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|
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| Activity |
IC50 = 53000 nM
|
[12] | |||
| Compound Name |
3-Hydroxy-4-(9-octylcarbazol-2-yl)oxy-1,2-dihydropyrrol-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812407; BDBM50484104
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|
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| Activity |
IC50 = 72000 nM
|
[8] | |||
| Compound Name |
2-(9-Octylcarbazol-2-yl)oxyacetonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812402; BDBM50484117
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|
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| Activity |
IC50 = 74000 nM
|
[8] | |||
| Compound Name |
2-[[Benzyl(propan-2-yl)amino]methyl]-2-ethyl-1-naphthalen-2-ylbutan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3799376; BDBM50500995
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|
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| Activity |
IC50 ~ 75000 nM
|
[13] | |||
| Compound Name |
2-(9-Octylcarbazol-2-yl)oxyethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812411; BDBM50484107
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|
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| Activity |
IC50 ~ 80000 nM
|
[8] | |||
| Compound Name |
2-[4-[(E)-C-(4-Chlorophenyl)-N-hexadecoxycarbonimidoyl]phenoxy]-2-methylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081782; BDBM50481889
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|
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| Activity |
IC50 ~ 80000 nM
|
[14] | |||
| Compound Name |
2,2,2-Trifluoro-N-[2-(9-octylcarbazol-2-yl)oxyethyl]-N-(2,2,2-trifluoroacetyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812415; BDBM50484119
Click to Show/Hide
|
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| Activity |
IC50 ~ 80000 nM
|
[8] | |||
| Compound Name |
2-[9-[[3-[3-(Trifluoromethyl)diazirin-3-yl]phenyl]methyl]carbazol-2-yl]oxyacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081581; BDBM50481896
Click to Show/Hide
|
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| Activity |
IC50 ~ 80000 nM
|
[14] | |||
| Compound Name |
(3Z)-3-[[4-[[4-(Dimethylamino)phenyl]diazenyl]phenyl]methylidene]-1H-indol-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206023
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|
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| Activity |
IC50 ~ 80000 nM
|
[15] | |||
| Compound Name |
2-[9-[[4-(2-Cyanophenyl)phenyl]methyl]carbazol-2-yl]oxyacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1075708; BDBM50481895
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|
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| Activity |
IC50 ~ 80000 nM
|
[14] | |||
| Compound Name |
2-(9-Octadecylcarbazol-2-yl)oxyacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1079451; BDBM50481905
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|
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| Activity |
IC50 ~ 80000 nM
|
[14] | |||
| Compound Name |
3-[2-(Carboxymethoxy)-9-octylcarbazol-3-yl]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812417; BDBM50484122
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|
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| Activity |
IC50 ~ 80000 nM
|
[8] | |||
| Compound Name |
3-(9-Octylcarbazol-2-yl)oxypropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812403; BDBM50484101
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|
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| Activity |
IC50 ~ 80000 nM
|
[8] | |||
| Compound Name |
2-[3-(Hydroxymethyl)-9-octylcarbazol-2-yl]oxyethanol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812418; BDBM50484113
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|
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| Activity |
IC50 = 80000 nM
|
[8] | |||
| Compound Name |
N-[2-(9-Octylcarbazol-2-yl)oxyethyl]formamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812414; BDBM50484112
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|
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| Activity |
IC50 ~ 80000 nM
|
[8] | |||
| Compound Name |
2-Methylpropyl 2-(9-octylcarbazol-2-yl)oxyacetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812425; BDBM50484108
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|
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| Activity |
IC50 ~ 80000 nM
|
[8] | |||
| Compound Name |
2-(9-Octylcarbazol-2-yl)oxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812405; BDBM50484102
Click to Show/Hide
|
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| Activity |
IC50 ~ 80000 nM
|
[8] | |||
| Compound Name |
9-Octylcarbazol-2-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812399; SCHEMBL6859813; BDBM50484115
Click to Show/Hide
|
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| Activity |
IC50 ~ 80000 nM
|
[8] | |||
| Compound Name |
3-Hydroxy-4-(9-octylcarbazol-2-yl)oxy-2H-furan-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812406; BDBM50484103
Click to Show/Hide
|
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| Activity |
IC50 ~ 80000 nM
|
[8] | |||
| Compound Name |
2-(9-Octylcarbazol-2-yl)oxyethanesulfonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812404; BDBM50484131
Click to Show/Hide
|
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| Activity |
IC50 ~ 80000 nM
|
[8] | |||
| Compound Name |
Benzyl 2-(6-chloro-9-octylcarbazol-2-yl)propanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812420; BDBM50484133
Click to Show/Hide
|
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| Activity |
IC50 ~ 80000 nM
|
[8] | |||
| Compound Name |
2-[9-[4-[[4-(Dimethylamino)phenyl]diazenyl]phenyl]sulfonylcarbazol-2-yl]oxyacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1079649; BDBM50481894
Click to Show/Hide
|
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| Activity |
IC50 ~ 80000 nM
|
[14] | |||
| Compound Name |
2-[4-[(E)-C-(4-Chlorophenyl)-N-tetradecoxycarbonimidoyl]phenoxy]-2-methylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081781; BDBM50481888
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 80000 nM
|
[14] | |||
| Compound Name |
2-[4-[(E)-C-(4-Chlorophenyl)-N-decoxycarbonimidoyl]phenoxy]-2-methylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1079820; BDBM50481899
Click to Show/Hide
|
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| Activity |
EC50 ~ 80000 nM
|
[14] | |||
| Compound Name |
N-[(3,4-Dichlorophenyl)methyl]-1-hydroxy-N-propan-2-ylnaphthalene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793752; BDBM50163311
Click to Show/Hide
|
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| Activity |
IC50 = 85000 nM
|
[16] | |||
| Compound Name |
Methyl 2-(3-formyl-9-octylcarbazol-2-yl)oxyacetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812427; BDBM50484110
Click to Show/Hide
|
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| Activity |
IC50 = 89000 nM
|
[8] | |||
| Compound Name |
1-Hydroxy-N-[(4-methoxyphenyl)methyl]-N-propan-2-ylnaphthalene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3792849; BDBM50163312
Click to Show/Hide
|
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| Activity |
IC50 = 95000 nM
|
[16] | |||
| Compound Name |
N-Benzyl-1-hydroxy-N-propan-2-ylnaphthalene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3794005; BDBM50163309
Click to Show/Hide
|
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| Activity |
IC50 = 96000 nM
|
[16] | |||
| Compound Name |
(R)-2-(4-Methoxy-3-(4-(trifluoromethyl)benzylcarbamoyl)benzyl)butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL115604; BDBM50109109; N-[4-(Trifluoromethyl)benzyl]-2-methoxy-5-[(2R)-2-carboxybutyl]benzamide; (R)-2-[4-Methoxy-3-(4-trifluoromethyl-benzylcarbamoyl)-benzyl]-butyric acid; (2R)-2-[[4-methoxy-3-[[4-(trifluoromethyl)phenyl]methylcarbamoyl]phenyl]methyl]butanoic acid
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(2S,3R)-2,3-Bis(benzyloxy)cyclohexanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL208581; BDBM50186503
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
2-[3,4-Bis[4-(trifluoromethyl)phenyl]phenyl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604727; SCHEMBL4597847; BDBM50481789
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Methyl 2-benzyl-3-oxopiperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL211287; BDBM50186505
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(2R)-2-[3-Phenylmethoxy-5-[4-(trifluoromethyl)phenyl]phenyl]pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597884; SCHEMBL3567174; BDBM50481773
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2S,3R)-3-(Benzyloxy)-5-hydroxy-2-methoxycyclohexanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209705; BDBM50186509
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(2S,3R)-3-(Benzyloxy)-2-methoxycyclohexanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL211497; BDBM50186511; (2S,3R)-3-(Benzyloxy)-2-methoxycyclohexane-1-one
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| Activity |
IC50 ~ 100000 nM
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[17] | |||
| Compound Name |
Sodium;2-[(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]pentyl]piperidin-4-yl]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL598450; BDBM50481774
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| Activity |
IC50 ~ 100000 nM
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[11] | |||
| Compound Name |
Benzenepropanoic acid, alpha-ethyl-4-methoxy-3-((((4-(trifluoromethyl)phenyl)methyl)amino)carbonyl)-, (alphaS)-
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Investigative | Compound Info | ||
| Synonyms |
KCL-1999000269; UNII-19KW9LD704; CHEMBL107789; 19KW9LD704; (+)-KCL-1999000269; SCHEMBL6374864; BDBM50109110; Q27252110; (S)-2-(4-methoxy-3-(4-(trifluoromethyl)benzylcarbamoyl)benzyl)butanoic acid; (S)-2-[4-Methoxy-3-(4-trifluoromethyl-benzylcarbamoyl)-benzyl]-butyric acid
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Dapt
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Investigative | Compound Info | ||
| Synonyms |
DAPT (GSI-IX); GSI-IX; gamma-Secretase Inhibitor IX; CHEMBL255682; MFCD04974585; N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine tert-butyl ester; N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester; GSIIX; PubChem22436; DAPT,GSI-IX; DAPT;; LY-374973; DAPT - GSI-IX; N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester; InSolution gamma-Secretase Inhibitor IX; MLS006010075; QCR-29; SCHEMBL1360313; TB2634-GMP; KS-00000SRB; DTXSID00415519; EX-A324; C23H26F2N2O4; HMS3413L17; HMS3677L17; HMS3884P09; AOB33372; EBD16444; ZINC1549363; ABP000317; BDBM50478375; s2215; AKOS024457209; CCG-264944; CS-0264; SB19494; MRF-0000012; NCGC00167803-03; (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu; AC-23163; AN-37124; AS-19399; HY-13027; SC-94298; SMR004701228; AB0033805; D4257; SW219339-1; X7572; W-5319; AB01566837_01; J-013656; J-524356; Q27158972; (3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester; N-[N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycine tert-butyl ester; N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester; N-[2-(3,5-Difluorophenyl)acetyl]-L-alanyl-L-(2-phenyl)glycine tert-butyl ester; N-[N-(3,5-difluorophenacetyl)-L-alanyl]-(S)-phenylglycine tert-butyl ester;; N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester;; N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-(S)-phenylglycine tert-butyl ester;; N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-L-phenylglycine tert-butyl ester;; tert-butyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)acetate
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| Activity |
IC50 ~ 100000 nM
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[18] | |||
| Compound Name |
Methyl 2-benzyl-3-hydroxypiperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL209225; BDBM50186517
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| Activity |
IC50 ~ 100000 nM
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[17] | |||
| Compound Name |
3-[[4-(Trifluoromethyl)benzyl]carbamoyl]-4-methoxy-alpha-ethylbenzeneacrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1221487; BDBM50482595
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Benzyl 2-benzyl-3-oxopiperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL378711; SCHEMBL5353802; BDBM50186516; N-(benzyloxycarbonyl)-2-phenylmethyl-3-piperidone; 2-Benzyl-3-oxopiperidine-1-carboxylic acid benzyl ester
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| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(2S,3R)-2-Hydroxy-3-methoxycyclohexanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL377363; BDBM50186515
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| Activity |
IC50 ~ 100000 nM
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[17] | |||
| Compound Name |
5-[6-[[(1S)-1-(4-Fluorophenyl)ethyl]amino]pyridin-3-yl]-N-methyl-2-(4-methylimidazol-1-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808605; BDBM50484080
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| Activity |
IC50 ~ 100000 nM
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[10] | |||
| Compound Name |
Benzyl 2-benzyl-3-hydroxypiperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL377425; BDBM50186499; 2-Benzyl-3-hydroxypiperidine-1-carboxylic acid benzyl ester
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| Activity |
IC50 ~ 100000 nM
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[17] | |||
| Compound Name |
Sodium;2-[(2S,4R)-2-[4-(trifluoromethyl)phenyl]-1-[(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]heptyl]piperidin-4-yl]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL599683; BDBM50481790
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| Activity |
IC50 = 100000 nM
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[11] | |||
| Compound Name |
3-(Benzyl(isopropyl)amino)-1-(naphthalen-2-yl)propan-1-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3798465; SCHEMBL2888672; BDBM50500994; 3-[benzyl(propan-2-yl)amino]-1-naphthalen-2-ylpropan-1-ol
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| Activity |
IC50 ~ 100000 nM
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[13] | |||
| Compound Name |
(2S,3R)-2-(Benzyloxy)-5-hydroxy-3-methoxycyclohexanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL424878; BDBM50186501
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| Activity |
IC50 ~ 100000 nM
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[17] | |||
| Compound Name |
Sodium;2-[(2S,4R)-1-[(1R)-4-methyl-1-[6-(trifluoromethyl)pyridin-3-yl]pentyl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL597226; GSM-A; BDBM50481777
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| Activity |
IC50 = 100000 nM
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[11] | |||
| Compound Name |
Sodium;2-[(2S,4R)-1-[(1R)-2-methyl-1-[6-(trifluoromethyl)pyridin-3-yl]propyl]-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL604928; BDBM50481787
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| Activity |
IC50 ~ 100000 nM
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[11] | |||
| Compound Name |
(2S,3R)-3-Hydroxy-2-methoxycyclohexanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL212617; BDBM50186514
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| Activity |
IC50 ~ 100000 nM
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[17] | |||
| Compound Name |
2-(6-Chloro-9-octylcarbazol-2-yl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL375635; BDBM50484099
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| Activity |
IC50 = 100000 nM
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[8] | |||
| Compound Name |
9-Octyl-2-(2H-tetrazol-5-ylmethoxy)carbazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812410; BDBM50484106
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| Activity |
IC50 = 102000 nM
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[8] | |||
| Compound Name |
2-(9-Octylcarbazol-2-yl)oxyacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812419; BDBM50484126
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| Activity |
IC50 = 104000 nM
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[8] | |||
| Compound Name |
N-[(3,4-Dichlorophenyl)methyl]-N-propan-2-ylnaphthalene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793199; BDBM50163310
Click to Show/Hide
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| Activity |
IC50 = 135000 nM
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[16] | |||
| Compound Name |
4-[4-[(Z)-(5-Chloro-2-oxo-1H-indol-3-ylidene)methyl]-2-methoxyphenoxy]butanenitrile
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206017; BDBM50402070
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| Activity |
IC50 ~ 160000 nM
|
[15] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of novel scaffolds for -secretase modulators without an arylimidazole moiety. Bioorg Med Chem. 2018 Jan 15;26(2):435-442. | ||||
| REF 2 | Potent benzoazepinone -secretase modulators with improved bioavailability. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3495-500. | ||||
| REF 3 | Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1269-71. | ||||
| REF 4 | Purine derivatives as potent gamma-secretase modulators. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2279-82. | ||||
| REF 5 | Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione -secretase modulators. J Med Chem. 2014 Feb 13;57(3):1046-62. | ||||
| REF 6 | Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active -secretase modulators. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2906-11. | ||||
| REF 7 | Triazoles as -secretase modulators. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4083-7. | ||||
| REF 8 | NSAID-derived -secretase modulation requires an acidic moiety on the carbazole scaffold. Bioorg Med Chem. 2011 Aug 15;19(16):4903-9. | ||||
| REF 9 | Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious -secretase modulators in vivo. J Med Chem. 2012 Jan 12;55(1):489-502. | ||||
| REF 10 | Pyridine-derived -secretase modulators. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4832-5. | ||||
| REF 11 | Piperidine-derived gamma-secretase modulators. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1306-11. | ||||
| REF 12 | Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5282-5. | ||||
| REF 13 | Part 2. Notch-sparing -secretase inhibitors: The study of novel -amino naphthyl alcohols. Bioorg Med Chem Lett. 2016 May 1;26(9):2133-7. | ||||
| REF 14 | NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6986-90. | ||||
| REF 15 | Modification of a promiscuous inhibitor shifts the inhibition from -secretase to FLT-3. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7634-40. | ||||
| REF 16 | Part 1: Notch-sparing -secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs. Bioorg Med Chem Lett. 2016 May 1;26(9):2129-32. | ||||
| REF 17 | Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. | ||||
| REF 18 | Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology. J Biol Chem. 2007 Dec 21;282(51):36829-36. | ||||
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