Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99029 | Target Info | |||
| Target Name | Pyruvate dehydrogenase kinase 3 (PDHK3) | ||||
| Synonyms |
Pyruvate dehydrogenase kinase isoform 3; PDK3
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| Target Type | Literature-reported Target | ||||
| Gene Name | PDK3 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Melanotetan II
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Preclinical | Compound Info | ||
| Synonyms |
Monorden; UNII-I60EH8GECX; I60EH8GECX; CHEMBL414883; CHEBI:556075; (1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione; Monorderne; RDC; C18H17ClO6; Radisicol; Radicolol; Monorden A; RHI-12648; Microlactone, 1; 3cgy; NSC-294404; 4egk; 2wer; NSC 294404; 2zbk; 1bgq; (+)-Monorden A; Radicicol R 2146; 2q8i; SCHEMBL868832; BDBM15361; MolPort-003-959-447; HMS3648C16; BDBM227589; 6H-Oxireno(e)(2)benzoxacyclotetradecin-6,12(7H)-dione, 8-chlor
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| Activity |
IC50 = 230000 nM
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[1] | |||
| Compound Name |
Dichloroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
2,2-Dichloroacetic acid; Dichloracetic acid; Acetic acid, dichloro-; Dichloroethanoic acid; Urner's liquid; Dichlorethanoic acid; Bichloracetic acid; Acetic acid, 2,2-dichloro-; DCA (acid); DICHLORO-ACETIC ACID; Kyselina dichloroctova; UNII-9LSH52S3LQ; NSC 2654; MFCD00004223; 9LSH52S3LQ; NSC-2654; NCGC00091444-02; DSSTox_CID_428; Dichloroacetic acid, 99+%; DSSTox_RID_75580; DSSTox_GSID_20428; C2H2Cl2O2; Dichloroacetic acid (IUPAC); SMR000059158; Kyselina dichloroctova [Czech]; CCRIS 4016; HSDB 6894; EINECS 201-207-0; UN1764; BRN 1098596; AI3-18370; Dichloressigsaeure; DKhUK; dichloro acetic acid; WLN: QVYGG; ACMC-1BLM2; 2,2-dichloro-acetic acid; SCHEMBL7777; 4-02-00-00498 (Beilstein Handbook Reference); KSC377O2D; MLS000028893; MLS001074861; MLS001424165; CHEMBL13960; DTXSID2020428; CTK2H7721; KS-00000VOI; NSC2654; BDBM227588; HMS2051P22; HMS2232H11; HMS3370D12; HMS3393P22; ZINC3830689; Dichloroacetic acid, puriss., 99%; Tox21_111133; Tox21_202363; Tox21_300419; Acetic acid, dichloro- (8CI,9CI); ANW-37297; BBL011449; LMFA01090070; STL146561; AKOS005720869; Tox21_111133_1; CCG-101070; DB08809; MCULE-1246638159; NC00320; NE10301; UN 1764; Dichloroacetic acid, analytical standard; NCGC00091444-01; NCGC00091444-03; NCGC00091444-04; NCGC00167845-02; NCGC00254261-01; NCGC00259912-01; AS-14228; SC-18205; DB-056364; D0308; Dichloroacetic acid [UN1764] [Corrosive]; Dichloroacetic acid, biotech. grade, >=98%; FT-0624700; Dichloroacetic acid, ReagentPlus(R), >=99%; EN300-20014; C11149; 11029-EP2269610A2; 11029-EP2289510A1; 11029-EP2316457A1; 11029-EP2316458A1; 11029-EP2316825A1; 11029-EP2316826A1; 11029-EP2316827A1; 11029-EP2316828A1; 12408-EP2277848A1; 12408-EP2277878A1; 12408-EP2295503A1; 12408-EP2298772A1; 12408-EP2301918A1; 12408-EP2305649A1; 12408-EP2316974A1; Q412845; F2191-0226
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| Activity |
IC50 = 5560000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90. J Med Chem. 2014 Dec 11;57(23):9832-43. | ||||
| REF 2 | Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors. J Med Chem. 2017 Mar 23;60(6):2227-2244. | ||||
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