Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T98896 | Target Info | |||
| Target Name | Aggrecanase (ADAMTS5) | ||||
| Synonyms |
Aggrecanase-2; ADMP-2; ADAMTS5; ADAMTS-5; ADAM-TS5; ADAM-TS 5; ADAM-TS 11; A disintegrin and metalloproteinase with thrombospondinmotifs 5
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| Target Type | Clinical trial Target | ||||
| Gene Name | ADAMTS5 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 30 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(4S)-4-[(4-Phenylbenzoyl)amino]-4-[5-(2-phenylethyl)-1,3,4-oxadiazol-2-yl]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807393; BDBM50349168
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| Activity |
IC50 = 57300 nM
|
[1] | |||
| Compound Name |
1-[[2-(4-Phenylphenoxy)acetyl]amino]-3-[(4-phenylphenyl)methyl]thiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437179; BDBM50441584
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| Activity |
IC50 = 60000 nM
|
[2] | |||
| Compound Name |
5-(3-(3,5-Dichlorophenoxy)benzylidene)imidazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL230835; BDBM50202156
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| Activity |
IC50 ~ 67000 nM
|
[3] | |||
| Compound Name |
5-(3,4-Bis(benzyloxy)benzylidene)-3-ethyl-2-thioxothiazolidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL411998; BDBM50202176
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| Activity |
IC50 ~ 67000 nM
|
[3] | |||
| Compound Name |
5-(3,4-Bis(benzyloxy)benzylidene)-3-methyl-2-thioxothiazolidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL397938; BDBM50202154
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| Activity |
IC50 ~ 67000 nM
|
[3] | |||
| Compound Name |
5-(3-(4-Tert-butylphenoxy)benzylidene)imidazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL230836; BDBM50202159
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| Activity |
IC50 ~ 67000 nM
|
[3] | |||
| Compound Name |
5-(3,4-Bis(benzyloxy)benzylidene)-3-phenethyl-2-thioxothiazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230787; BDBM50202171
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| Activity |
IC50 ~ 67000 nM
|
[3] | |||
| Compound Name |
5-(3-(4-Chlorophenoxy)benzylidene)imidazolidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230834; BDBM50202160
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| Activity |
IC50 ~ 67000 nM
|
[3] | |||
| Compound Name |
5-(3,4-Bis(benzyloxy)benzylidene)-3-benzyl-2-thioxothiazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL229990; BDBM50202172
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| Activity |
IC50 ~ 67000 nM
|
[3] | |||
| Compound Name |
5-(3,4-Bis(benzyloxy)benzylidene)-3-phenyl-2-thioxothiazolidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL397912; BDBM50202148
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| Activity |
IC50 ~ 67000 nM
|
[3] | |||
| Compound Name |
5-(4-Chlorobenzyloxymethyl)-4-(4-phenylbenzyl)-3-(methylmercapto)-4H-[1,2,4]triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270666; BDBM50329005
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-(4-Chlorophenoxy)-N-[3-[(4-phenylphenyl)methyl]-2-sulfanylideneimidazol-1-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437149; BDBM50441576
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(4-Chlorophenoxy)-N-[2-[(4-phenylphenyl)methylamino]-2-sulfanylideneethyl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437150; BDBM50441577
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-Acetamido-3-(4-cyclohexylbutyl)thiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437154; BDBM50441580
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Potassium;5-(6-chloro-3,4-dihydro-2H-1,4-benzoxazin-2-yl)-4-[(4-phenylphenyl)methyl]-1,2,4-triazole-3-thiolate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270273
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-(4-Cyclohexylbutyl)-3-[[2-(4-methoxyphenoxy)acetyl]amino]thiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437161; BDBM50441581
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-[[2-(4-Chlorophenoxy)acetyl]-methylamino]-3-[(4-phenylphenyl)methyl]thiourea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437152; BDBM50441579
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-[[2-(4-Chlorophenoxy)acetyl]-methylamino]-3-(4-cyclohexylbutyl)thiourea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437151; BDBM50441578
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-[[2-(4-Chlorophenoxy)acetyl]amino]-3-(pyridin-3-ylmethyl)thiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437169; BDBM50441575
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|
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
Potassium;4-[(2-phenylphenyl)methyl]-5-[(4-phenylphenyl)methyl]-1,2,4-triazole-3-thiolate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270467
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Potassium;4-(3-imidazol-1-ylpropyl)-5-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethyl]-1,2,4-triazole-3-thiolate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270567
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-(4-Cyclohexylbutyl)-3-[(2-phenoxyacetyl)amino]thiourea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437162; BDBM50441582
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Potassium;4-benzyl-5-[(4-chlorophenoxy)methyl]-1,2,4-triazole-3-thiolate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270068
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
5-(4-Chlorobenzyloxymethyl)-4-(2-phenylbenzyl)-3-(methylmercapto)-4H-[1,2,4]triazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270667; BDBM50329006
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Potassium;5-[(4-chlorophenoxy)methyl]-4-(2-phenylethyl)-1,2,4-triazole-3-thiolate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270069
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Potassium;5-[(4-chlorophenoxy)methyl]-4-(3-phenylpropyl)-1,2,4-triazole-3-thiolate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270070
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Potassium;5-[(4-fluorophenoxy)methyl]-4-[(4-phenylphenyl)methyl]-1,2,4-triazole-3-thiolate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270177
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-[[2-(4-Fluorophenoxy)acetyl]amino]-3-[(4-phenylphenyl)methyl]thiourea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437188; BDBM50441583
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|
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
3-(4-Butoxyphenylamino)-4-(hydroxy(isopropyl)amino)cyclobut-3-ene-1,2-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL495508; BDBM50265022
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
5-[[4-(3-Imidazol-1-ylpropyl)-5-methylsulfanyl-1,2,4-triazol-3-yl]methyl]-3-phenyl-1,2,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1270768; BDBM50329007
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity study on a series of alpha-glutamic acid scaffold based compounds as new ADAMTS inhibitors. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4457-61. | ||||
| REF 2 | Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group. Eur J Med Chem. 2013 Nov;69:244-61. | ||||
| REF 3 | Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorg Med Chem Lett. 2007 Mar 1;17(5):1185-8. | ||||
| REF 4 | New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6213-6. | ||||
| REF 5 | Synthesis of a 200-member library of squaric acid N-hydroxylamide amides. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4968-71. | ||||
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