Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T98293 | Target Info | |||
| Target Name | PAK-4 protein kinase (PAK4) | ||||
| Synonyms |
p21-activated kinase 4; Serine/threonine-protein kinase PAK 4; PAK-4; KIAA1142
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PAK4 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 18 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-(1-(2,3-Dichlorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682354; SCHEMBL3668411; BDBM50337322; 5-[1-[(2,3-dichlorophenyl)methyl]triazol-4-yl]-1H-indazole
Click to Show/Hide
|
||||
| Activity |
Ki = 67636 nM
|
[1] | |||
| Compound Name |
5-(1H-1,2,3-Triazol-4-yl)-1H-indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682344; SCHEMBL3667012; 5-(2H-triazol-4-yl)-1H-indazole; BDBM50337313
Click to Show/Hide
|
||||
| Activity |
Ki = 69911 nM
|
[1] | |||
| Compound Name |
3-Methyl-4-(2-phenoxyacetamido)-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199759; BDBM50175252
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
6-Phenyl-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL262623; Kinome_3598; BDBM50376344
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
6-Phenyl-7,8-dihydro-9H-pyrimido[4,5-b][1,4]diazepine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259380; BDBM50376351
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
6-(3-Methylphenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263902; BDBM50376350
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Methyl 3-(piperidin-1-yl)-1H-thieno[2,3-c]pyrazole-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200348; BDBM50175233
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
6-(3-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407532; BDBM50376348
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
6-(4-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407265; BDBM50376347
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(2-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371695; BDBM50175235
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
6-(3-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259381; BDBM50376346
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
6-(4-Methylphenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL405233; BDBM50376349
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
6-(4-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL260620; BDBM50376345
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Methyl-4-(thiophene-2-carboxamido)-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL382070; BDBM50175246
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(3-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199657; BDBM50175253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Methyl 3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200586; SCHEMBL14163466; BDBM50175248; ZINC28564886
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(4-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199658; BDBM50175244
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Methyl 2-(5-carbamoyl-3-methyl-1H-thieno[2,3-c]pyrazol-4-ylamino)-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370199; BDBM50175250
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Scaffold oriented synthesis. Part 3: design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing [2+3] cycloadditions. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1476-9. | ||||
| REF 2 | Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors. Bioorg Med Chem Lett. 2006 Jan 1;16(1):96-9. | ||||
| REF 3 | Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2691-5. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.