Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T98091 | Target Info | |||
| Target Name | Inflammation-related GPCR EX33 (GPR84) | ||||
| Synonyms |
Inflammation-related G-protein coupled receptor EX33; G-protein coupled receptor 84; EX33
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| Target Type | Clinical trial Target | ||||
| Gene Name | GPR84 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 18 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(4-Phenylbutylsulfanyl)-4-(trifluoromethyl)-1H-pyrimidin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828312; BDBM50189542
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
10-Hydroxylauric acid
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Investigative | Compound Info | ||
| Synonyms |
10-hydroxydodecanoic Acid; 10-hydroxy-dodecanoic acid; (omega-2)-hydroxylauric acid; SCHEMBL974964; CHEMBL4280780
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(Hexylthio)-6-hydroxy-3-methyl-4(3H)-pyrimidinone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827426; BDBM50189558; ZINC16513251; MCULE-7767393979; AB00081633-01; SR-01000205859; SR-01000205859-1
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
11-Hydroxylauric acid
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Investigative | Compound Info | ||
| Synonyms |
11-Hydroxydodecanoic acid; Dodecanoic acid, 11-hydroxy-; 11-hydroxy-dodecanoic acid; Dodecanoic acid,11-hydroxy-; 11-HYDROXY LAURIC ACID; SCHEMBL1882126; CHEMBL4291425; CTK4G8742; DTXSID00954211; LMFA01050165; AKOS027447761; J-018745; Q27146452
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Hexylsulfanyl-4-(7-hydroxyheptoxy)-1H-pyrimidin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827415; BDBM50189557
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
6-Hydroxydodecanoic acid
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Investigative | Compound Info | ||
| Synonyms |
6-hydroxylauric acid; SCHEMBL667755; CHEMBL4279005; CTK8I4014; DTXSID60275398
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Hydroxy-2-(8-hydroxyoctylsulfanyl)-1H-pyrimidin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827436; BDBM50189532
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Hydroxy-5-methyl-2-(4-phenylbutylsulfanyl)-1H-pyrimidin-6-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828567; BDBM50189543
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Amino-2-(4-phenylbutylsulfanyl)-1H-pyrimidin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827486; BDBM50189550
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
6-Hexyloxy-2-hexylsulfanyl-pyrimidin-4-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827681; BDBM50189556; MFCD30726018; ZINC604941652
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
9-Hydroxy-dodecanoic acid
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Investigative | Compound Info | ||
| Synonyms |
9-hydroxydodecanoic acid; 9-hydroxylauric acid; LMFA01050167; (omega-3)-hydroxylauric acid; SCHEMBL1881322; CHEMBL4288021
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
7-Hydroxylauric acid
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Investigative | Compound Info | ||
| Synonyms |
7-hydroxydodecanoic acid; 7-hydroxy-dodecanoic acid; LMFA01050166; SCHEMBL1527361; CHEMBL4287270; C21080; Q27158612
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(4-Phenylbutylsulfanyl)pyrimidine-4,6-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827707; BDBM50189552
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-(4-Hydroxy-6-oxo-1H-pyrimidin-2-yl)pentanenitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827809; BDBM50189531
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Hydroxydodecaneoic acid sodium salt
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4294243
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Methyl-2-(4-phenylbutylsulfanyl)-1H-pyrimidin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827253; BDBM50189541
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
8-Hydroxydodecanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
8-hydroxylauric acid; Dodecanoic acid, 8-hydroxy-; 8-hydroxy-dodecanoic acid; (omega-4)-hydroxylauric acid; SCHEMBL1882579; CHEMBL4277376; CTK0A8412; DTXSID20560515
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-Benzyl-2-hexylsulfanyl-6-hydroxypyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828716; BDBM50189548
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83. | ||||
| REF 2 | Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84. Medchemcomm. 2017 May 12;8(6):1360-1365. | ||||
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