Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T98078 | Target Info | |||
| Target Name | Malonyl-CoA decarboxylase (MLYCD) | ||||
| Synonyms |
Malonyl-CoA decarboxylase, mitochondrial; MCD
Click to Show/Hide
|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | MLYCD | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 14 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(E)-Methyl 3-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-2-isopropyl-1H-imidazol-5-yl)acrylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL381676; BDBM50176198
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
1-(2-Sec-butyl-1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-1H-imidazol-5-yl)-2-methylpropan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370452; SCHEMBL2938106; BDBM50176201
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[1] | |||
| Compound Name |
Methyl 3-(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-2-isopropyl-1H-imidazol-5-yl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202161; SCHEMBL2944595; BDBM50176149
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[1] | |||
| Compound Name |
1-(2-Sec-butyl-1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-1H-imidazol-5-yl)butan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370343; SCHEMBL2941849; BDBM50176172; 1-[2-butan-2-yl-3-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]imidazol-4-yl]butan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[1] | |||
| Compound Name |
(E)-Methyl 3-(2-sec-butyl-1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-1H-imidazol-5-yl)acrylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370451; BDBM50176220
Click to Show/Hide
|
||||
| Activity |
IC50 = 88000 nM
|
[1] | |||
| Compound Name |
5-((1-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-2-isopropyl-1H-imidazol-5-yl)methoxy)pentanenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440043; SCHEMBL2943327; BDBM50176175
Click to Show/Hide
|
||||
| Activity |
IC50 = 107000 nM
|
[1] | |||
| Compound Name |
1,1,1,3,3,3-Hexafluoro-2-(4-(5-(hydroxymethyl)-2-(pyridin-4-yl)-1H-imidazol-1-yl)phenyl)propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL383613; SCHEMBL6843287; BDBM50176195; 1,1,1,3,3,3-hexafluoro-2-[4-[5-(hydroxymethyl)-2-pyridin-4-ylimidazol-1-yl]phenyl]propan-2-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 114000 nM
|
[1] | |||
| Compound Name |
2-(4-(5-((4-(1H-Tetrazol-5-yl)butoxy)methyl)-2-isopropyl-1H-imidazol-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202016; SCHEMBL6846307; BDBM50176193
Click to Show/Hide
|
||||
| Activity |
IC50 = 116000 nM
|
[1] | |||
| Compound Name |
trans-3-(1-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-2-isopropyl-1H-imidazol-5-yl)acrylonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL381423; SCHEMBL2937983; SCHEMBL2937985; BDBM50176186
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[1] | |||
| Compound Name |
2-(4-(2-Sec-butyl-5-(1-hydroxyethyl)-1H-imidazol-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202008; SCHEMBL6838926; BDBM50176207; 2-[4-[2-butan-2-yl-5-(1-hydroxyethyl)imidazol-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 149000 nM
|
[1] | |||
| Compound Name |
2-(4-(5-((5-(1H-Tetrazol-5-yl)pentyloxy)methyl)-2-isopropyl-1H-imidazol-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL402264; SCHEMBL6843409; BDBM50212236
Click to Show/Hide
|
||||
| Activity |
IC50 = 155000 nM
|
[1] | |||
| Compound Name |
3-(2-Sec-butyl-1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-1H-imidazol-5-yl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203691; BDBM50176191
Click to Show/Hide
|
||||
| Activity |
IC50 = 163000 nM
|
[1] | |||
| Compound Name |
6-((1-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-2-isopropyl-1H-imidazol-5-yl)methoxy)hexanenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202772; SCHEMBL2938671; BDBM50176179
Click to Show/Hide
|
||||
| Activity |
IC50 = 168000 nM
|
[1] | |||
| Compound Name |
Ethyl 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-2-(pyridin-4-yl)-1H-imidazole-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370601; SCHEMBL2942875; BDBM50176162
Click to Show/Hide
|
||||
| Activity |
IC50 = 191000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 15 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(1-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-2-isopropyl-1H-imidazol-5-yl)-2-methylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202333; BDBM50176167
Click to Show/Hide
|
||||
| Activity |
IC50 = 225000 nM
|
[1] | |||
| Compound Name |
3-(1-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-2-isopropyl-1H-imidazol-5-yl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378578; BDBM50176214
Click to Show/Hide
|
||||
| Activity |
IC50 = 239000 nM
|
[1] | |||
| Compound Name |
1,1,1,3,3,3-Hexafluoro-2-(4-(4-(hydroxymethyl)-2-isopropyl-1H-imidazol-1-yl)phenyl)propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370368; BDBM50176168
Click to Show/Hide
|
||||
| Activity |
IC50 = 243000 nM
|
[1] | |||
| Compound Name |
1,1,1,3,3,3-Hexafluoro-2-(4-(5-(hydroxymethyl)-2-isopropyl-1H-imidazol-1-yl)phenyl)propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370815; BDBM50176205
Click to Show/Hide
|
||||
| Activity |
IC50 = 274000 nM
|
[1] | |||
| Compound Name |
2-(4-(2-Sec-butyl-5-((butylamino)methyl)-1H-imidazol-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL201153; BDBM50176209
Click to Show/Hide
|
||||
| Activity |
IC50 = 303000 nM
|
[1] | |||
| Compound Name |
Ethyl 2-sec-butyl-1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-1H-imidazole-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202205; BDBM50176161
Click to Show/Hide
|
||||
| Activity |
IC50 = 318000 nM
|
[1] | |||
| Compound Name |
2-(4-(2-Sec-butyl-5-(hydroxymethyl)-1H-imidazol-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL381992; SCHEMBL14172955; BDBM50176196
Click to Show/Hide
|
||||
| Activity |
IC50 = 321000 nM
|
[1] | |||
| Compound Name |
2-(4-(2-Sec-butyl-5-((2-methoxyethylamino)methyl)-1H-imidazol-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202543; BDBM50176170
Click to Show/Hide
|
||||
| Activity |
IC50 = 340000 nM
|
[1] | |||
| Compound Name |
2-(4-(2-Sec-butyl-5-((isopropylamino)methyl)-1H-imidazol-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202285; BDBM50176166
Click to Show/Hide
|
||||
| Activity |
IC50 = 341000 nM
|
[1] | |||
| Compound Name |
2-(4-(2-Sec-butyl-5-(hydroxy(phenyl)methyl)-1H-imidazol-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL264476; BDBM50176212
Click to Show/Hide
|
||||
| Activity |
IC50 = 465000 nM
|
[1] | |||
| Compound Name |
2-(4-(5-((Butylamino)methyl)-2-isopropyl-1H-imidazol-1-yl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370189; BDBM50176213
Click to Show/Hide
|
||||
| Activity |
IC50 = 482000 nM
|
[1] | |||
| Compound Name |
(E)-3-(2-Sec-butyl-1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-1H-imidazol-5-yl)acrylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL201050; SCHEMBL2943120; SCHEMBL2943121; BDBM50176199
Click to Show/Hide
|
||||
| Activity |
IC50 = 523000 nM
|
[1] | |||
| Compound Name |
1,1,1,3,3,3-Hexafluoro-2-(4-(2-isopropyl-4-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202497; BDBM50176169
Click to Show/Hide
|
||||
| Activity |
IC50 = 567000 nM
|
[1] | |||
| Compound Name |
1,1,1,3,3,3-Hexafluoro-2-(4-(5-(hydroxymethyl)-2-(pyridin-2-yl)-1H-imidazol-1-yl)phenyl)propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL382903; BDBM50176200
Click to Show/Hide
|
||||
| Activity |
IC50 = 791000 nM
|
[1] | |||
| Compound Name |
3-(4-((1-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-2-isopropyl-1H-imidazol-5-yl)methyl)morpholin-2-yl)-N-isopropylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202179; BDBM50176164
Click to Show/Hide
|
||||
| Activity |
IC50 = 1080000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design and synthesis of heterocyclic malonyl-CoA decarboxylase inhibitors. Bioorg Med Chem Lett. 2006 Feb;16(3):695-700. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.