Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T97592 | Target Info | |||
| Target Name | Aurora kinase C (AURKC) | ||||
| Synonyms |
Serine/threonine-protein kinase aurora-C; STK13; Aurora/Ipl1/Eg2 protein 2; Aurora/Ipl1-related kinase 3; Aurora-related kinase 3; Aurora-C; Aurora 3; ARK3; ARK-3; AIRK3; AIK3; AIE2
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| Target Type | Clinical trial Target | ||||
| Gene Name | AURKC | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
7-Chloroindirubin-3-acetoxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL397719; BDBM50218886
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
7-Bromoindirubin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL214173; CHEMBL397718; (2'Z)-7-bromoindirubin; (2''Z)-7-bromoindirubin; SCHEMBL22300869; cid_11845789; (3Z)-7-bromo-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; BDBM50191440; BDBM50218890; UNM-0000305768
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
7-Iodoindirubin-3-methoxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL244191; BDBM50218903
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
7-Bromoindirubin-3-methoxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL243556; BDBM50218902
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-Fluoroindirubin-3-methoxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL397720; BDBM50218901
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
7-Chloroindirubin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL243777; CHEMBL378191; (2'Z)-7-chloroindirubin; (2''Z)-7-chloroindirubin; SCHEMBL21440315; cid_11847137; (3Z)-7-chloro-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; BDBM50191445; BDBM50218889; UNM-0000305769
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-Fluoroindirubin
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Investigative | Compound Info | ||
| Synonyms |
(2'Z)-7-fluoroindirubin; CHEMBL210446; CHEMBL243986; (2''''Z)-7-Fluoroindirubin; SCHEMBL22300875; cid_11847138; (3Z)-7-fluoro-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; BDBM50024791; BDBM50218896; UNM-0000305767
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-7-Iodo-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL379160; 7-iodoindirubin; (2'Z)-7-iodoindirubin; (2''Z)-7-iodoindirubin; CHEMBL395078; SCHEMBL22300068; BDBM50191449
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
7-Chloroindirubin-3-methoxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL243776; BDBM50218887
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
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| Activity |
Ki > 1000000 nM
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[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. | ||||
| REF 2 | Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. | ||||
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