Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T97388 | Target Info | |||
| Target Name | Uridine phosphorylase (UPP) | ||||
| Synonyms |
UrdPase; UPase
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| Target Type | Literature-reported Target | ||||
| Gene Name | UPP1; UPP2 | ||||
| Biochemical Class | Pentosyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2R,4R,5R,6S)-4-(Azidomethyl)-5-hydroxy-11-methyl-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-10-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3644513; BDBM135808; US8853227, TK- 000011
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| Activity | Uridine phosphorylase 1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
(2R,4S,6S)-4-(Fluoromethyl)-5-hydroxy-11-methyl-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-10-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3644514; SCHEMBL12039591; BDBM135809; US8853227, TK- 000015
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| Activity | Uridine phosphorylase 1 |
IC50 ~ 100000 nM
|
[1] | ||
| Compound Name |
[(2R,4R,5R,6S)-5-Hydroxy-4-(hydroxymethyl)-10-oxo-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-11-yl]methyl ethanimidate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3644512; SCHEMBL12039588; BDBM135807; US8853227, TK- 000010
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| Activity | Uridine phosphorylase 1 |
IC50 ~ 100000 nM
|
[1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | US patent application no. 8853227B2, Methotrexate adjuvants to reduce toxicity and methods for using the same | ||||
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