Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T96736 | Target Info | |||
| Target Name | Transforming protein RhoA (RHOA) | ||||
| Synonyms |
h12; Rho cDNA clone 12; RHO12; ARHA; ARH12
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|
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| Target Type | Discontinued Target | ||||
| Gene Name | RHOA | ||||
| Biochemical Class | Small GTPase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(4-Chlorophenyl)-1-[3-(diethylsulfamoyl)benzoyl]piperidine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2398687; BDBM50436227
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| Activity |
IC50 = 51000 nM
|
[1] | |||
| Compound Name |
1-[3,5-Bis(trifluoromethyl)benzoyl]-N-(3-nitrophenyl)piperidine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2398710; BDBM50436246
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| Activity |
IC50 = 66000 nM
|
[1] | |||
| Compound Name |
Methyl 3-[3-[(4-chlorophenyl)carbamoyl]piperidine-1-carbonyl]benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2398688; BDBM50436226
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| Activity |
IC50 = 67000 nM
|
[1] | |||
| Compound Name |
N-(3-Acetylphenyl)-1-[3,5-bis(trifluoromethyl)benzoyl]piperidine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2398711; BDBM50436245
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| Activity |
IC50 = 76000 nM
|
[1] | |||
| Compound Name |
N-(4-Chlorophenyl)-1-[3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoyl]piperidine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2398689; BDBM50436225
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| Activity |
IC50 = 78000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3826-32. | ||||
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