Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T96413 | Target Info | |||
| Target Name | Beta-glucuronidase (GUSB) | ||||
| Synonyms |
Beta-G1
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| Target Type | Successful Target | ||||
| Gene Name | GUSB | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 11 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(3-Nitrophenyl)-1H-quinazolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3289111; 2-(3-nitrophenyl)quinazolin-4(3H)-one; SCHEMBL873782; BDBM50019169; CCG-55167; ZINC18191243; MCULE-1141827527; 2-(3-nitrophenyl)-3H-quinazolin-4-one; 2-(3-Nitrophenyl)quinazoline-4(3H)-one; SR-01000644209-1
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| Activity |
IC50 = 50400 nM
|
[1] | |||
| Compound Name |
8-Fluoro-N-[(E)-(3-methylphenyl)methylideneamino]-4-oxo-1H-quinoline-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3814892; BDBM50180317
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| Activity |
IC50 = 51000 nM
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[2] | |||
| Compound Name |
2-(2,4-Dichlorophenyl)quinazolin-4-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3289118; 2-(2,4-dichlorophenyl)-1H-quinazolin-4-one; Oprea1_466441; SCHEMBL801880; CTK3D1279; DTXSID20383125; ZINC9216542; BDBM50019256; STL333078; AKOS002257639; MCULE-8698057145; 2-(2,4-dichlorophenyl)-4-quinazolinol; ST50195329; 2-(2,4-Dichlorophenyl)quinazolin-4(1H)-one; 2-(2,4-dichlorophenyl)quinazolin-4(3h)-one; 2-(2,4-Dichlorophenyl)quinazoline-4(3H)-one; 4(1H)-Quinazolinone, 2-(2,4-dichlorophenyl)-; AB00682262-01; F3098-1205
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| Activity |
IC50 = 61030 nM
|
[1] | |||
| Compound Name |
8-Fluoro-4-oxo-N-[(E)-pyridin-3-ylmethylideneamino]-1H-quinoline-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3814358; BDBM50180324
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| Activity |
IC50 = 68380 nM
|
[2] | |||
| Compound Name |
8-Fluoro-N-[(E)-(4-methoxyphenyl)methylideneamino]-4-oxo-1H-quinoline-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3814781; BDBM50180314
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| Activity |
IC50 = 69400 nM
|
[2] | |||
| Compound Name |
8-Fluoro-N-[(E)-(3-nitrophenyl)methylideneamino]-4-oxo-1H-quinoline-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3813783; BDBM50180366
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| Activity |
IC50 = 78900 nM
|
[2] | |||
| Compound Name |
8-Fluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]-4-oxo-1H-quinoline-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3814856; BDBM50180315
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| Activity |
IC50 = 80100 nM
|
[2] | |||
| Compound Name |
2-(3,4,5-Trimethoxyphenyl)-1H-quinazolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3289114; Maybridge3_001346; Oprea1_253350; Oprea1_256216; SCHEMBL16017996; HMS1434N04; ZINC5091860; BDBM50019172; CCG-18244; MCULE-2150546791; IDI1_012733; 2-(3,4,5-trimethoxyphenyl)quinazolin-4-ol; EU-0074572; SR-01000459456; 2-(3,4,5-Trimethoxyphenyl)quinazoline-4(3H)-one; SR-01000459456-1; 2-(3,4,5-trimethoxyphenyl)-3,4-dihydroquinazolin-4-one
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| Activity |
IC50 = 120500 nM
|
[1] | |||
| Compound Name |
2-(4-Methylphenyl)quinazolin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
2-(4-methylphenyl)-4(3H)-quinazolinone; 2-(4-Methylphenyl)-3,4-Dihydroquinazolin-4-One; 2-P-TOLYLQUINAZOLIN-4(3H)-ONE; CHEMBL3289109; 2-(4-methylphenyl)-1H-quinazolin-4-one; CBMicro_021454; 2-(p-tolyl)-4-quinazolone; Oprea1_396009; Oprea1_546314; SCHEMBL1083787; SCHEMBL15775687; 2-p-Tolyl-3H-quinazolin-4-one; DTXSID90353976; HMS3436N05; 2-(4-methylphenyl)quinazolin-4-ol; CCG-9118; ZINC8714038; 2-(p-Tolyl)quinazolin-4(3H)-one; BBL000439; BDBM50019167; MFCD00446432; STL102686; AKOS002256929; AKOS003218655; MCULE-4342992554; BIM-0021581.P001; 2-(4-methylphenyl)-quinazolin-4(3H)-one; BB 0242833; H2516; ST50192458; AB00682210-01; SR-01000389717; SR-01000389717-1; Q27465594
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| Activity |
IC50 = 172700 nM
|
[1] | |||
| Compound Name |
2-Phenylquinazolin-4-ol
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Investigative | Compound Info | ||
| Synonyms |
2-Phenyl-3H-quinazolin-4-one; 2-phenylquinazolin-4(3H)-one; 4(1H)-Quinazolinone, 2-phenyl-; 2-Phenyl-4(3H)-quinazolinone; 4(3H)-Quinazolinone,2-phenyl-; 2-Phenyl-4-quinazolone; 2-Phenyl-4-quinazolinone; CHEMBL127066; F0342-0101; C14H10N2O; 2-phenyl-3-hydroquinazolin-4-one; 2-phenyl-1H-quinazolin-4-one; NSC400966; 2-phenyl-4-quinazolinol; Maybridge1_006625; 2-Phenyl-quinazolin-4-ol; 2-phenyl-quinazoline 4-ol; TimTec1_001395; Oprea1_322129; MLS001182239; 2-phenyl-4-hydroxyquinazoline; SCHEMBL258433; QUI026; CTK4A0857; CTK7H0178; HMS560F03; DTXSID60299539; HMS1537P09; HMS2851L13; BCP27506; ANW-52755; BDBM50106305; BDBM50188599; MFCD00451430; NSC131274; SBB096317; STK711916; STL560568; ZINC17917305; AKOS000281935; AKOS003935469; AKOS015900263; CCG-247406; MCULE-5967317312; NSC-131274; NSC-400966; VZ34800; AC-20408; BS-14188; SMR000567884; ST015582; 2-Phenyl-4(3H)-quinazolinone, AldrichCPR; DB-000863; AM20020100; FT-0741948; AG-205/01758001; BRD-K10785533-001-01-3; BRD-K10785533-001-03-9; BRD-K10785533-001-07-0; Q27460145
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| Activity |
IC50 = 177000 nM
|
[1] | |||
| Compound Name |
2-(3-Hydroxyphenyl)quinazolin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3289110; 2-(3-hydroxyphenyl)-3~{H}-quinazolin-4-one; SCHEMBL873906; CS-M2492; BDBM50019168; ZINC48603426; AKOS034523840; CCG-347757; MCULE-9551653249; CS-14651; 2-(3-hydroxyphenyl)-1H-quinazolin-4-one; 2-(3-hydroxyphenyl)-3H-quinazolin-4-one; 2-(3-hydroxyphenyl)-3,4-dihydroquinazolin-4-one; Z666586268
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| Activity |
IC50 = 198200 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N,N-Bis(3,5-dimethylpyrazol-1-ylmethyl)-cyclohexylamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1968195; NSC720862; BDBM50486773; NSC-720862; NCI60_041421; 1,1'-(Cyclohexyliminobismethylene)bis(3,5-dimethyl-1H-pyrazole); 3,5,5'-tetra-methyl-N,N-Bis(pyrazol-1-ylmethyl)cyclohexyl amine
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| Activity |
IC50 = 456600 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and -glucuronidase inhibitory activity of 2-arylquinazolin-4(3H)-ones. Bioorg Med Chem. 2014 Jul 1;22(13):3449-54. | ||||
| REF 2 | Synthesis and biological evaluation of novel N-arylidenequinoline-3-carbohydrazides as potent -glucuronidase inhibitors. Bioorg Med Chem. 2016 Aug 15;24(16):3696-704. | ||||
| REF 3 | Synthesis and enzyme inhibitory activities of some new pyrazole-based heterocyclic compounds. Med Chem Res. 2011 Oct 21;21:2772-8. | ||||
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