Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T96079 | Target Info | |||
| Target Name | C-X-C chemokine receptor type 4 (CXCR4) | ||||
| Synonyms |
Stromal cell-derived factor 1 receptor; SDF-1 receptor; NPYRL; Lipopolysaccharide-associated protein 3; Leukocyte-derived seven transmembrane domain receptor; LPS-associated protein 3; LESTR; LCR1; LAP-3; HM89; Fusin; FB22; Chemokine receptor CXCR4; CXCR-4; CXC-R4; CD184 antigen; CD184
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | CXCR4 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 34 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
11-Butyl-3-[1-(4,6-dimethylpyrimidine-5-carbonyl)-4-methyl-4-piperidyl]-9-[(4-ethoxycyclohexyl)methyl]-3,9-diazaspiro[5.5]undecan-10-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL449621; SCHEMBL3963928; BDBM50254750
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
PharmaGSID_48521
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1078231; DSSTox_CID_28495; DSSTox_RID_82770; DSSTox_GSID_48521; DTXSID8048521; SCHEMBL18841093; Tox21_303454; BDBM50310739; NCGC00257432-01
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4159140
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50277325; Cyclo[-(D-Ala)-Arg-Arg-Nal-Gly-]; Cyclo[-Arg-Arg-Nal-Gly-(D-Ala)-]
Click to Show/Hide
|
||||
| Activity |
EC50 = 51000 nM
|
[3] | |||
| Compound Name |
4-[[4-(4-Benzyl-1H-pyrazol-5-yl)-1-piperidyl]methyl]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3608763; SCHEMBL17262681; BDBM50112266; ZINC67724213; MCULE-9792526180
Click to Show/Hide
|
||||
| Activity |
EC50 = 52000 nM
|
[4] | |||
| Compound Name |
(2S)-5-(Diaminomethylideneamino)-2-[5-(diaminomethylideneamino)pentanoylamino]-N-(2-naphthalen-2-ylethyl)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3327366; BDBM50100599
Click to Show/Hide
|
||||
| Activity |
EC50 = 57543.99 nM
|
[5] | |||
| Compound Name |
1-(4-Methylbenzyl)-1,4,8,11-tetraazacyclotetradecane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL122226; SCHEMBL21610014; AMD-3389; BDBM50035719; 1-(p-tolylmethyl)-1,4,8,11-tetrazacyclotetradecane; 1-(4-Methyl-benzyl)-1,4,8,11tetraaza-cyclotetradecane
Click to Show/Hide
|
||||
| Activity |
Ki = 60000 nM
|
[6] | |||
| Compound Name |
N,4-Dimethyl-N-(2-(thiophene-3-carbonyl)phenyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604583; BDBM50305731
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[7] | |||
| Compound Name |
2-[3-[(2R,5S,8S)-5-[3-(Diaminomethylideneamino)propyl]-8-(naphthalen-2-ylmethyl)-3,6,9,12-tetraoxo-1,4,7,10-tetrazacyclododec-2-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3327373; BDBM50100606
Click to Show/Hide
|
||||
| Activity |
EC50 = 60000 nM
|
[5] | |||
| Compound Name |
[(4-Methylphenyl)sulfonyl](2-{[(4-methylphenyl)sulfonyl]prop-2-enylamino}pheny l)prop-2-enylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604277; ZINC2573080; BDBM50305737; SBB057090; AKOS024364667; MCULE-3639320640; ST50997002; N,N'-Diallyl-N,N'-ditosyl-1,2-benzenediamine; N,N''-(1,2-phenylene)bis(N-allyl-4-methylbenzenesulfonamide)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[7] | |||
| Compound Name |
n,n'-1,2-Phenylenebis(n,4-dimethylbenzenesulfonamide)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595990; NSC101062; Oprea1_370376; CBDivE_001423; DTXSID20295299; ZINC636919; BDBM50305735; AKOS002161609; MCULE-1311888097; NSC-101062; N,N-o-phenylene-bis(p-toluenesulfonamide); ST50036099; p-Toluenesulfonamide,N'-o-phenylenebis[N-methyl-; N,N'-Ditosyl-N,N'-dimethyl-1,2-phenylenediamine; N,N''-(1,2-phenylene)bis(N-methyl-1-phenylmethanesulfonamide)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[7] | |||
| Compound Name |
2-[3-[(6S)-8-[(1-Bromonaphthalen-2-yl)methyl]-3-[3-(diaminomethylideneamino)propyl]-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-6-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3956669; BDBM50207533
Click to Show/Hide
|
||||
| Activity |
EC50 = 61000 nM
|
[8] | |||
| Compound Name |
2-[3-[(3S,6S,9Ar)-3-[3-(diaminomethylideneamino)propyl]-8-(2-naphthalen-2-ylethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-6-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3327376; BDBM50100610
Click to Show/Hide
|
||||
| Activity |
EC50 = 63095.73 nM
|
[5] | |||
| Compound Name |
2-[3-[(3R,6S,9As)-3-[3-(diaminomethylideneamino)propyl]-8-(2-naphthalen-2-ylethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-6-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3327375; BDBM50100609
Click to Show/Hide
|
||||
| Activity |
EC50 = 79432.82 nM
|
[5] | |||
| Compound Name |
(2R)-2-Acetamido-N-[(2S)-1-[[(2S)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-5-(diaminomethylideneamino)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3327367; BDBM50100600
Click to Show/Hide
|
||||
| Activity |
EC50 = 85113.8 nM
|
[5] | |||
| Compound Name |
2-[2-[(3S,6S,9Ar)-6-[4-(diaminomethylideneamino)butyl]-8-(2-naphthalen-2-ylethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-3-yl]ethyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3911275; BDBM50207537
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-[3-[(6S)-3-[3-(Diaminomethylideneamino)propyl]-8-(naphthalen-1-ylmethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-6-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3929127; BDBM50207536
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-[3-[(3S,6S,9Ar)-6-[4-(diaminomethylideneamino)butyl]-8-(2-naphthalen-2-ylethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-3-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3931202; BDBM50207538
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-[3-[(2R,5S,8S)-2-[3-(Diaminomethylideneamino)propyl]-8-(naphthalen-2-ylmethyl)-3,6,9,13-tetraoxo-1,4,7,10-tetrazacyclotridec-5-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3327372; BDBM50100605
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-[3-[(3R,6S,9As)-3-[2-(diaminomethylideneamino)ethyl]-8-(2-naphthalen-2-ylethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-6-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3897010; BDBM50207531
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-[3-[(2R,5S,8S)-2-[3-(Diaminomethylideneamino)propyl]-8-(naphthalen-2-ylmethyl)-3,6,9,15-tetraoxo-1,4,7,10-tetrazacyclopentadec-5-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3327369; BDBM50100602
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-[(2S,5S,11R,14S)-14-[3-(Diaminomethylideneamino)propyl]-11-[(4-hydroxyphenyl)methyl]-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2179711
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[3-[(3R,6S,9As)-6-[4-(diaminomethylideneamino)butyl]-8-(2-naphthalen-2-ylethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-3-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3939235; BDBM50207532
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-[3-[(3R,6S,9As)-3-[4-(diaminomethylideneamino)butyl]-8-(2-naphthalen-2-ylethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-6-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3957870; BDBM50207534
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-[2-[(3R,6S,9As)-6-[4-(diaminomethylideneamino)butyl]-8-(2-naphthalen-2-ylethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-3-yl]ethyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3930236; BDBM50207530
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-[3-[(3S,6S,9Ar)-3-[4-(diaminomethylideneamino)butyl]-8-(2-naphthalen-2-ylethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-6-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3925060; BDBM50207528
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-[3-[(4R,7S,10S,13S)-10-[3-(Diaminomethylideneamino)propyl]-4-[(4-hydroxyphenyl)methyl]-13-(naphthalen-2-ylmethyl)-2,5,8,14-tetraoxo-1,3,6,9,12-pentazacyclotetradec-7-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192290; BDBM50159211
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-[3-[(6S)-3-[3-(Diaminomethylideneamino)propyl]-8-(naphthalen-2-ylmethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-6-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3902257; BDBM50207535
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[(3S,6S,9Ar)-6-[3-(diaminomethylideneamino)propyl]-8-(2-naphthalen-2-ylethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-3-yl]-2-(diaminomethylideneamino)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3327374; BDBM50100608
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-[3-[(2R,5S,8S)-2-[3-(Diaminomethylideneamino)propyl]-8-(naphthalen-2-ylmethyl)-3,6,9,16-tetraoxo-1,4,7,10-tetrazacyclohexadec-5-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3327370; BDBM50100603
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[(3R,6S,9As)-6-[3-(diaminomethylideneamino)propyl]-8-(2-naphthalen-2-ylethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-3-yl]-2-(diaminomethylideneamino)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325468; BDBM50100607
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-[3-[(2R,5S,8S)-2-[3-(Diaminomethylideneamino)propyl]-8-(naphthalen-2-ylmethyl)-3,6,9,14-tetraoxo-1,4,7,10-tetrazacyclotetradec-5-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3327371; BDBM50100604
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-[(2S,5S,8S,14R)-5-[3-(Carbamoylamino)propyl]-14-[(4-hydroxyphenyl)methyl]-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2179710; BDBM50398989
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[3-[(3S,6S,9Ar)-3-[2-(diaminomethylideneamino)ethyl]-8-(2-naphthalen-2-ylethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[2,1-b][1,3]thiazin-6-yl]propyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3933958; BDBM50207529
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-Phenyl-N-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL478168; N-[1,4,8,11-Tetraazacyclotetradecanyl-1,4-phenylenebis(methylene)]-benzylamine; AMD3529; SCHEMBL14640063; AMD-3529; BDBM50270277; Benzyl-[4-(1,4,8,11tetraaza-cyclotetradec-1-ylmethyl)-benzyl]-amine; N-Benzyl-4-(1,4,8,11-tetraazacyclotetradecane-1-ylmethyl)benzenemethaneamine
Click to Show/Hide
|
||||
| Activity |
Ki = 128000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 17 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Pyridinemethanamine, N-((4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl)methyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AMD 3465; AMD-8664; AMD3465; AMD-3465; UNII-IMD9Z48ZTT; IMD9Z48ZTT; CHEMBL477121; AMD3465 hexahydrobromide; AMD3465 (*Hexahydrobromide*); SCHEMBL13527941; AMD 3465 (*Hexahydrobromide*); AMD-3465 (*Hexahydrobromide*); BDBM50270276; HY-15971A; ZINC19361903; FT-0689764; Q27280798; Pyridin-2-ylmethyl-[4-(1,4,8,11tetraaza-cyclotetradec-1-ylmethyl)-benzyl]-amine
Click to Show/Hide
|
||||
| Activity |
Ki = 215000 nM
|
[6] | |||
| Compound Name |
4-Fluoro-N-[[4-[[(4-fluorophenyl)amino]methyl]phenyl]methyl]aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237438; SCHEMBL10055033; CTK2F9193; BDBM194532; ZINC396314; AKOS024323941; MCULE-3199685254; US9205085, MSX- 142; ALPHA,ALPHA'-BIS(4-FLUOROANILINO)-P-XYLENE
Click to Show/Hide
|
||||
| Activity |
EC50 = 1000000 nM
|
[11] | |||
| Compound Name |
m-Terephthalanisidide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
n,n'-bis(3-methoxyphenyl)terephthalamide; 3,3'-Dimethoxy terephthalanilide; NSC65108; Cambridge id 5181399; NCIOpen2_008073; Oprea1_876909; CHEMBL237164; SCHEMBL10055020; DTXSID20989626; BDBM194527; ZINC642712; NSC-65108; AKOS001403578; MCULE-5259770780; N,N'-bis(m-methoxyphenyl)terephthalamide; 3',3''-3,3'-Dimethoxy terephthalanilide; US9205085, MSX- 137; N~1~,N~4~-Bis(3-methoxyphenyl)benzene-1,4-dicarboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 = 1000000 nM
|
[11] | |||
| Compound Name |
N-(4-{[3-(Trifluoromethyl)anilino]methyl}benzyl)-N-[3-(trifluoromethyl)phenyl]amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237630; SCHEMBL10055021; BDBM194528; ZINC2147364; AKOS024430782; MCULE-2746896664; US9205085, MSX- 138
Click to Show/Hide
|
||||
| Activity |
EC50 = 1000000 nM
|
[11] | |||
| Compound Name |
4-Nitro-N-(4-{[(4-nitrophenyl)amino]methyl}benzyl)aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237437; SCHEMBL4953680; BDBM194549; US9205085, MSX- 178; 4-nitro-N-[[4-[(4-nitroanilino)methyl]phenyl]methyl]aniline
Click to Show/Hide
|
||||
| Activity |
EC50 = 1000000 nM
|
[11] | |||
| Compound Name |
US9205085, Msx-173
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235312; SCHEMBL10055007; BDBM194517; US9205085, MSX- 173
Click to Show/Hide
|
||||
| Activity |
EC50 = 5011872.34 nM
|
[11] | |||
| Compound Name |
N-Methyl-N-[[4-[(N-methylanilino)methyl]phenyl]methyl]aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237415; SCHEMBL10054994; BDBM194539; US9205085, MSX- 164
Click to Show/Hide
|
||||
| Activity |
EC50 = 5011872.34 nM
|
[11] | |||
| Compound Name |
US9205085, Msx-184
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237628; SCHEMBL10055035; BDBM194555; US9205085, MSX- 184
Click to Show/Hide
|
||||
| Activity |
EC50 = 10000000 nM
|
[11] | |||
| Compound Name |
1,4-Bis-(1-anilinoethyl) benzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396667; SCHEMBL10054998; BDBM194516; US9205085, MSX- 169; N-[1-[4-(1-anilinoethyl)phenyl]ethyl]aniline
Click to Show/Hide
|
||||
| Activity |
EC50 = 19952623.15 nM
|
[11] | |||
| Compound Name |
N,N'-(1,4-Phenylenedimethylidyne)DI-P-anisidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391151; SCHEMBL10055019; BDBM194522; ZINC396400; AKOS024334968; MCULE-9629254732; US9205085, MSX- 125
Click to Show/Hide
|
||||
| Activity |
EC50 = 39810717.06 nM
|
[11] | |||
| Compound Name |
US9205085, Msx-206
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237829; SCHEMBL10055049; BDBM194572; US9205085, MSX- 206
Click to Show/Hide
|
||||
| Activity |
EC50 = 100000000 nM
|
[11] | |||
| Compound Name |
US9205085, Msx-172
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235310; SCHEMBL10055003; BDBM194544; US9205085, MSX- 172
Click to Show/Hide
|
||||
| Activity |
EC50 = 100000000 nM
|
[11] | |||
| Compound Name |
4-Methyl-N-[4-(4-toluidinomethyl)benzyl]aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237439; SCHEMBL10055032; BDBM194529; ZINC6546506; US9205085, MSX- 139
Click to Show/Hide
|
||||
| Activity |
EC50 = 100000000 nM
|
[11] | |||
| Compound Name |
US9205085, Msx-205
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237629; SCHEMBL10055018; BDBM194521; US9205085, MSX- 205
Click to Show/Hide
|
||||
| Activity |
EC50 = 1000000000 nM
|
[11] | |||
| Compound Name |
US9205085, Msx-183
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM194554; US9205085, MSX- 183; CHEMBL237631; SCHEMBL10055034; BDBM194518
Click to Show/Hide
|
||||
| Activity |
EC50 = 1000000000 nM
|
[11] | |||
| Compound Name |
N-[[4-[(Pyridin-2-ylamino)methyl]phenyl]methyl]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
WZ811; WZ 811; WZ-811; N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine; N,N'-(1,4-phenylenebis(methylene))bis(pyridin-2-amine); CHEMBL237830; N,N'-(1,4-Phenylenebis(methylene))-bis(pyridin-2-amine); MFCD18086914; N,N'-(1,4-phenylenebis(methylene))dipyridin-2-amine; cc-645; SCHEMBL589266; CTK8G3785; AOB6805; DTXSID10468697; EX-A116; HMS3651F10; HMS3750C15; BCP06492; BDBM50225415; s2912; ZINC28863086; AKOS024457893; CCG-267383; 1,4-bis(pyridine-2-aminomethyl)benzene; AC-32781; AK175864; AS-16967; DA-42093; HY-15478; QC-10228; SC-95597; WZ811, >=98% (HPLC); AB0035817; FT-0700332; SW219530-1; Y0219; A12588; W-5709; N,N''-di-2-pyridinyl-1,4-benzenedimethanamine; N,N''-(Benzene-1,4-diyldimethanediyl)dipyridin-2-amine; N,N'-[1,4-Phenylenebis(methylene)]di(2-pyridinamine); N-[(4-{[(Pyridin-2-yl)amino]methyl}phenyl)methyl]pyridin-2-amine
Click to Show/Hide
|
||||
| Activity |
EC50 = 1000000000 nM
|
[11] | |||
| Compound Name |
US9205085, Msx-203
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL392423; SCHEMBL10055046; BDBM194570; US9205085, MSX- 203
Click to Show/Hide
|
||||
| Activity |
EC50 = 1000000000 nM
|
[11] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of a potent, selective and orally bioavailable 3,9-diazaspiro[5.5]undeca-2-one CCR5 antagonist. Bioorg Med Chem Lett. 2009 Jan 1;19(1):209-13. | ||||
| REF 2 | Spiropiperidine CCR5 antagonists. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5401-6. | ||||
| REF 3 | An update on small molecules targeting CXCR4 as starting points for the development of anti-cancer therapeutics. Eur J Med Chem. 2017 Oct 20;139:519-530. | ||||
| REF 4 | Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase. ACS Med Chem Lett. 2015 May 6;6(7):753-7. | ||||
| REF 5 | Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4). Bioorg Med Chem. 2014 Sep 1;22(17):4759-69. | ||||
| REF 6 | Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor. J Biol Chem. 2007 Sep 14;282(37):27354-27365. | ||||
| REF 7 | Identification of a new class of small molecule C5a receptor antagonists. Bioorg Med Chem Lett. 2010 Jan 15;20(2):662-4. | ||||
| REF 8 | Influence of chain length on the activity of tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4). Bioorg Med Chem. 2017 Jan 15;25(2):646-657. | ||||
| REF 9 | Rational design of conformationally constrained cyclopentapeptide antagonists for C-x-C chemokine receptor 4 (CXCR4). J Med Chem. 2012 Nov 26;55(22):10287-91. | ||||
| REF 10 | Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem. 2005 Jan 27;48(2):380-91. | ||||
| REF 11 | Discovery of small molecule CXCR4 antagonists. J Med Chem. 2007 Nov 15;50(23):5655-64. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.