Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95682 | Target Info | |||
| Target Name | Bromodomain adjacent to zinc finger 2A (BAZ2A) | ||||
| Synonyms |
hWALp3; Transcription termination factor I-interacting protein 5; Tip5; TTF-I-interacting protein 5; KIAA0314; Bromodomain adjacent to zinc finger domain protein 2A
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| Target Type | Literature-reported Target | ||||
| Gene Name | BAZ2A | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID25719566C1
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Investigative | Compound Info | ||
| Synonyms |
GTPL8302; MolPort-016-611-562; ZINC65410133; BDBM50078632; MCULE-6970562839; 43C
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| Activity |
IC50 = 51000 nM
|
[1] | |||
| Compound Name |
4-[3-[2-(4-Methyltriazol-1-yl)ethyl]imidazol-4-yl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415181; BDBM50078639
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[3-Methyl-5-(1-methylpyrazol-4-yl)imidazol-4-yl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415183; BDBM50078637
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[3-[2-(4-Methyltriazol-1-yl)ethyl]-5-pyridin-3-ylimidazol-4-yl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415178; BDBM50078630
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[5-(3-Methyl-1,2-oxazol-5-yl)-3-[2-(4-methyltriazol-1-yl)ethyl]imidazol-4-yl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3415180; BDBM50078640
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-Cyano-N-(1,3-diethyl-2-oxoquinolin-6-yl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059509; BDBM50249797
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B. J Med Chem. 2015 Mar 12;58(5):2553-9. | ||||
| REF 2 | Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies. J Med Chem. 2017 Jan 26;60(2):668-680. | ||||
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