Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95286 | Target Info | |||
| Target Name | Myelin-associated glycoprotein (MAG) | ||||
| Synonyms |
MAG
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| Target Type | Clinical trial Target | ||||
| Gene Name | MAG | ||||
| Biochemical Class | Immunoglobulin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sodium;(2S,4S,5R,6R)-5-acetamido-2-[(2R,3R,4S,5S,6R)-2-[(2R,3R,4R,5R,6S)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-phenylmethoxyoxan-4-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836309
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[2-[4-(4-hydroxyphenyl)phenyl]acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methoxyphenoxy)oxan-2-yl]methoxy]oxane-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501599; GSC-660; BDBM50274296
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| Activity |
IC50 = 136000 nM
|
[2] | |||
| Compound Name |
(2R,4S,5R,6R)-6-[(1R,2R)-1,2-Dihydroxy-3-[[2-[4-(4-hydroxyphenyl)phenyl]acetyl]amino]propyl]-4-hydroxy-5-[(2-hydroxyacetyl)amino]-2-[(4-phenylphenyl)methoxy]oxane-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1684361; BDBM50338744
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| Activity |
IC50 = 164000 nM
|
[2] | |||
| Compound Name |
Benzyl 3,5,9-trideoxy-5-glycolamido-9-(4''-hydroxy-4-biphenyl)acetamido-D-glycero-alpha-D-galacto-2-nonulopyranosidonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1684360; GSC-718; BDBM50338743
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| Activity |
IC50 = 171000 nM
|
[2] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sodium;(2S,4S,5R,6R)-5-acetamido-2-[(2R,3R,4S,5S,6R)-2-[(2R,3R,4R,5R,6S)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-(4-methylphenyl)sulfanyloxan-4-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836308
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|
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| Activity |
IC50 = 272000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | High affinity sialoside ligands of myelin associated glycoprotein. Bioorg Med Chem Lett. 2011 Sep 1;21(17):5045-9. | ||||
| REF 2 | CD22-antagonists with nanomolar potency: the synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold. Bioorg Med Chem. 2011 Mar 15;19(6):1966-71. | ||||
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