Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95183 | Target Info | |||
| Target Name | Ubiquitin carboxyl-terminal hydrolase 2 (USP2) | ||||
| Synonyms |
Ubiquitin-specific-processing protease 2; Ubiquitin thioesterase 2; UBP41; Deubiquitinating enzyme 2; 41 kDa ubiquitin-specific protease
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| Target Type | Preclinical Target | ||||
| Gene Name | USP2 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4203286
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Investigative | Compound Info | ||
| Synonyms |
BDBM50458419; AKOS034771573; MCULE-4413751636; Z98910613; [5-(thiophen-2-yl)-1,2-oxazol-3-yl]methyl 2-(4-cyanophenoxy)propanoate
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
N-[(3-Acetamidophenyl)methyl]-3-phenylmethoxy-1-benzothiophene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4089822; BDBM50269827
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| Activity |
IC50 = 66080 nM
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[2] | |||
| Compound Name |
Chembl4203489
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Investigative | Compound Info | ||
| Synonyms |
ZINC9364219; BDBM50458417; AKOS001309655; MCULE-9481489936; Z98800725; [5-(thiophen-2-yl)-1,2-oxazol-3-yl]methyl 4-oxo-3-propyl-3,4-dihydrophthalazine-1-carboxylate
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
Chebi:149900
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233809; N-[(3-acetamidophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide; BDBM50007788; N-[3-(Acetylamino)benzyl]-1-[(R)-1-(1-naphthyl)ethyl]piperidine-4-carboxamide
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[5-(2-Thienyl)-3-isoxazolyl]methanol
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Investigative | Compound Info | ||
| Synonyms |
[5-(thiophen-2-yl)-1,2-oxazol-3-yl]methanol; (5-(thiophen-2-yl)isoxazol-3-yl)methanol; (5-Thiophen-2-Ylisoxazol-3-Yl)methanol; (5-thiophen-2-yl-1,2-oxazol-3-yl)methanol; 3-Isoxazolemethanol,5-(2-thienyl)-; CHEMBL1230155; (5-(2-THIENYL)-3-ISOXAZOLYL)METHANOL; SCHEMBL19668537; CTK4E1541; DTXSID80380175; ACT07577; ZINC2506138; BDBM50458416; MFCD03086162; SBB077831; AKOS002671691; MCULE-1309795573; SDCCGMLS-0066041.P001; [5-(2-thienyl)isoxazol-3-yl]methanol; (5-(2-thienyl)isoxazol-3-yl)methan-1-ol; (5-Thiophen-2-yl-isoxazol-3-yl)-methanol; DB-026850; FT-0605438; Y8125; (5-(Thiophen-2-yl)isoxazol-3-yl)methanol .; L-3977; W-206437; Q27453934; F2135-0540
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| Activity |
IC50 = 1300000 nM
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[1] | |||
| Compound Name |
3,5-Dimethyl-4-hydroxybenzonitrile
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Investigative | Compound Info | ||
| Synonyms |
4-Hydroxy-3,5-dimethylbenzonitrile; 4-Cyano-2,6-dimethylphenol; 2,6-Dimethyl-4-cyanophenol; 4-Hydroxy-3,5-DiMethyl-Benzonitrile; 3,5-dimethyl-4-hydroxy benzonitrile; BENZONITRILE, 3,5-DIMETHYL-4-HYDROXY-; MFCD00221716; CHEMBL4207620; 3,5-Dimethyl-4-hydroxybenzonitrile, 97%; 4-hydroxy-3,5-dimethylbenzenecarbonitrile; BRN 2574734; PubChem11065; ACMC-209jmm; KSC236A8T; SCHEMBL197918; CTK1D6089; DTXSID00194791; ZINC162656; ACT12497; ALBB-016105; 3,5,-dimethyl-4-hydroxybenzonitrile; 3,5-dimethyl-4-hydroxy-benzonitrile; 4-hydroxy-3,5-dimethyl benzonitrile; ANW-29708; BDBM50458420; SBB005819; 4-hydroxy 3, 5-dimethyl benzonitrile; AKOS005256952; AC-8502; CS-W020066; DS-0804; MCULE-8888349386; PB30622; PS-4473; SB10009; KS-000002R7; AC-19781; AK-32495; BP-10033; BR-32495; ST092336; 4-Hydroxy-3,5-dimethylbenzonitrile, 98%; AB0018485; DB-028298; AM20060814; D2790; FT-0610687; FT-0614672; FT-0667461; EN300-91953; BENZONITRILE, 4-HYDROXY-3,5-DIMETHYL-; C-8863; 21555-EP2305660A1; 21555-EP2314295A1; 876H153; J-515484
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| Activity |
IC50 > 5000000 nM
|
[1] | |||
| Compound Name |
3-Phenyl-1H-pyrazol-5-amine
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Investigative | Compound Info | ||
| Synonyms |
3-Amino-5-phenylpyrazole; 5-phenyl-1H-pyrazol-3-amine; 5-Amino-3-phenylpyrazole; 1H-Pyrazol-3-amine, 5-phenyl-; 1h-pyrazol-5-amine, 3-phenyl-; 3-amino-5-phenyl-1h-pyrazole; 5-Phenyl-2H-pyrazol-3-ylamine; MFCD00191749; 5-phenyl-1h-pyrazol-3-ylamine; CHEMBL1650269; 3-Amino-5-phenylpyrazole, 98%; Pyrazole, 5-amino-3-phenyl-; BRN 0004947; 5-phenyl-2H-pyrazol-3-amine; 5-amino-3-phenyl-1h-pyrazole; ACMC-209dfp; Maybridge1_004361; 3-amino-5-phenyl-pyrazole; 3-phenylpyrazole-5-ylamine; 5-phenylpyrazole-3-ylamine; 4-25-00-02617 (Beilstein Handbook Reference); SCHEMBL168659; 3-phenyl-5-(1H)pyrazolamine; 3-Amino-5-phenyl-2H-pyrazole; CTK3F0690; CTK7D5159; HMS553O07; 5-Phenyl-1H-pyrazole-3-ylamine; DTXSID80935629; HMS1665M09; ALBB-021641; BCP27110; KS-000004RU; KS-00001P3X; (5-phenyl-2H-pyrazol-3-yl)-amine; ANW-21683; ANW-72421; BBL013022; BDBM50458421; HTS004633; RW2659; SBB005555; STK168010; ZINC95093507; AKOS000111379; AKOS000206498; AA-0871; AC-7714; ACN-028954; CS-W021972; LS41271; MCULE-2652542982; QC-1242; QC-8968; SB13176; VP20125; AK-39960; SC-14982; SY011840; 5-Phenyl-1,2-dihydro-3H-pyrazol-3-imine; AB0010387; DB-050546; AM20030062; BB 0218353; BB 0218354; FT-0619995; FT-0619996; ST45255805; EN300-07991; Y-8585; 72372-EP2308867A2; 72372-EP2308870A2; A809823; J-513033; W-203881; F3250-0709; 3-(2,5-Dichlorophenyl)-1-hydroxy-1-(3-(trifluoromethyl)phenyl)urea
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| Activity |
IC50 > 5000000 nM
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[1] | |||
| Compound Name |
4-(1,2,3-Thiadiazol-4-yl)benzylamine hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4207578; [4-(thiadiazol-4-yl)phenyl]methanamine;hydrochloride; C9H10ClN3S; SCHEMBL1855124; CTK8E4512; DTXSID70371971; BDBM50458418; SBB097217; MCULE-8284047561; FT-0616445; Y7993; Benzenemethanamine,4-(1,2,3-thiadiazol-4-yl)-; W-206214; (4-(1,2,3-thiadiazol-4-yl)phenyl)methylamine, chloride; (4-(1,2,3-Thiadiazol-4-yl)phenyl)methanamine hydrochloride; [4-(1,2,3-Thiadiazol-4-yl)phenyl]methylamine hydrochloride; 4-(1,2,3-thiadiazol-4-yl)benzylamine hydrochloride, AldrichCPR
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| Activity |
IC50 > 5000000 nM
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[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of small-molecule inhibitors of USP2a. Eur J Med Chem. 2018 Apr 25;150:261-267. | ||||
| REF 2 | Development of a highly reliable assay for ubiquitin-specific protease 2 inhibitors. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4015-4018. | ||||
| REF 3 | X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases. J Med Chem. 2014 Mar 27;57(6):2393-412. | ||||
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