Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T94449 | Target Info | |||
| Target Name | Protein-tyrosine phosphatase eta (HPTP) | ||||
| Synonyms |
Receptor-type tyrosine-protein phosphatase eta; R-PTP-eta; R-PTP-J; Protein-tyrosine phosphatase receptor type J; HPTP eta; Density-enhanced phosphatase 1; DEP1; DEP-1; CD148
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| Target Type | Patented-recorded Target | ||||
| Gene Name | PTPRJ | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
{3(S)-Methylcarbamoyl-2-[3-(3-sulfoamino-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinolin-7-YL}-sulfamic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL204337; SCHEMBL6393262; BDBM13461; ZINC14952759; Tetrahydroisoquinoline (TIQ) deriv. 10i; Q27466911
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| Activity |
IC50 = 150000 nM
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[1] | |||
| Compound Name |
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Compound Info | |||
| Activity |
IC50 = 65617 nM
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[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1574-8. | ||||
| REF 2 | US patent application no. 8987474B2, Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs | ||||
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