Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93903 | Target Info | |||
| Target Name | Caspase-9 (CASP9) | ||||
| Synonyms |
MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease activating factor 3; Apoptotic protease Mch-6; APAF-3
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| Target Type | Clinical trial Target | ||||
| Gene Name | CASP9 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-(2-((Methyl(phenyl)amino)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62187; BDBM50297258; 5-{2-[(Methyl-phenyl-amino)-methyl]-pyrrolidine-1-sulfonyl}-1H-indole-2,3-dione
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| Activity |
Ki ~ 50000 nM
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[1] | |||
| Compound Name |
4-(Ethoxycarbonylmethoxy)-1-hydroxy-naphthalene-2-carboxylic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL479009; SCHEMBL7824970; ZINC402550; 4-(2-ethoxy-2-oxoethoxy)-1-hydroxynaphthalene-2-carboxylic acid; BDBM50270346; AKOS024325306; MCULE-9442446112; 1-hydroxy-4-ethoxycarbonylmethyloxy-2-naphthoic acid; 4-(2-Ethoxy-2-oxoethoxy)-1-hydroxy-2-naphthoic acid
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| Activity |
IC50 = 93000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem. 2001 Jun 7;44(12):2015-26. | ||||
| REF 2 | Structure-based discovery of a novel non-peptidic small molecular inhibitor of caspase-3. Bioorg Med Chem. 2008 May 1;16(9):4854-9. | ||||
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