Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93662 | Target Info | |||
| Target Name | Hyaluronidase (HYAL) | ||||
| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Cimicifugic acid L
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1097937; BDBM50316415
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|
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| Activity | Hyaluronidase 1 |
IC50 = 102000 nM
|
[1] | ||
| Compound Name |
Cimicifugic acid N
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094303; BDBM50316417
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|
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| Activity | Hyaluronidase 1 |
IC50 = 120000 nM
|
[1] | ||
| Compound Name |
Cimicifugic acid M
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096937; BDBM50316416
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|
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| Activity | Hyaluronidase 1 |
IC50 = 173000 nM
|
[1] | ||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3,4-Dihydroxycinnamic Acid
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|
Phase 4 | Compound Info | ||
| Synonyms |
Caffeic acid; caffeic acid; 3,4-Dihydroxycinnamic acid; 331-39-5; 3-(3,4-dihydroxyphenyl)acrylic acid; 501-16-6; (E)-3-(3,4-dihydroxyphenyl)acrylic acid; 3,4-Dihydroxybenzeneacrylic acid; (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; trans-caffeic acid; trans-Caffeate; 3,4-Dihydroxy-trans-cinnamate; 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-; Cinnamic acid, 3,4-dihydroxy-; 3-(3,4-Dihydroxyphenyl)propenoic acid; UNII-U2S3A33KVM; 3-(3,4-Dihydroxyphenyl)-2-propenoic acid; 4-(2-Carboxyethenyl)-1,2-dihydroxybenzene
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|
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| Activity | Hyaluronidase 1 |
IC50 > 2000000 nM
|
[1] | ||
| Compound Name |
FERULIC ACID
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|
Patented | Compound Info | ||
| Synonyms |
ferulic acid; trans-Ferulic Acid; 1135-24-6; 4-Hydroxy-3-methoxycinnamic acid; 537-98-4; trans-4-Hydroxy-3-methoxycinnamic acid; 3-(4-Hydroxy-3-methoxyphenyl)acrylic acid; (E)-Ferulic acid; ferulate; Coniferic acid; Ferulic acid, trans-; (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid; 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid; Cinnamic acid, 4-hydroxy-3-methoxy-; 3-methoxy-4-hydroxycinnamic acid; (E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid; UNII-AVM951ZWST; Cinnamic acid, 4-hydroxy-3-methoxy-, (E)-
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|
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| Activity | Hyaluronidase 1 |
IC50 > 2000000 nM
|
[1] | ||
| Compound Name |
ROSMARINIC ACID
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|
Investigative | Compound Info | ||
| Synonyms |
rosmarinic acid; 20283-92-5; Rosemary acid; (R)-rosmarinic acid; UNII-MQE6XG29YI; Rosmarinate; MQE6XG29YI; CHEMBL324842; CHEBI:50371; Labiatenic acid; C18H16O8; (R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid; 3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester; (2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]propanoic acid; 537-15-5; Rosemaric acid; (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-propanoic acid
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|
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| Activity | Hyaluronidase 1 |
IC50 = 545000 nM
|
[1] | ||
| Compound Name |
isoferulic acid
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|
Investigative | Compound Info | ||
| Synonyms |
Isoferulic acid; 3-Hydroxy-4-methoxycinnamic acid; 537-73-5; Hesperetic acid; 25522-33-2; 3-(3-Hydroxy-4-methoxyphenyl)acrylic acid; (2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid; (E)-3-(3-hydroxy-4-methoxyphenyl)acrylic acid; Isoferulate; 2-Propenoic acid, 3-(3-hydroxy-4-methoxyphenyl)-; 3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid; 3-hydroxy-4-methoxy-cinnamic acid; CHEMBL233295; CHEBI:27794; QURCVMIEKCOAJU-HWKANZROSA-N; AK-88788; UNII-XSQ2K2G7MC; Cinnamic acid, 3-hydroxy-4-methoxy-; Q-100609
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|
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| Activity | Hyaluronidase 1 |
IC50 > 2000000 nM
|
[1] | ||
| Compound Name |
Cimicifugic acid K
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096631; BDBM50316414; ZINC49783951
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|
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| Activity | Hyaluronidase 1 |
IC50 = 255000 nM
|
[1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Phenolic constituents of the aerial parts of Cimicifuga simplex and Cimicifuga japonica. J Nat Prod. 2010 Apr 23;73(4):609-12. | ||||
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