Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93283 | Target Info | |||
| Target Name | Prostatic acid phosphatase (ACPP) | ||||
| Synonyms |
Thiamine monophosphatase; TMPase; PAP
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | ACPP | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[Phenyl-(3-trifluoromethyl-phenyl)-methyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107374; BDBM50288660
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| Activity |
IC50 = 67000 nM
|
[1] | |||
| Compound Name |
(Biphenyl-4-yl-phenyl-methyl)-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104006; BDBM50288652; [phenyl-(4-phenylphenyl)methyl]phosphonic acid
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| Activity |
IC50 = 67000 nM
|
[1] | |||
| Compound Name |
(Bis-biphenyl-4-yl-methyl)-phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL108210; BDBM50288648
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| Activity |
IC50 = 70000 nM
|
[1] | |||
| Compound Name |
((3-Trifluoromethyl)phenyl)methyl-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
UNII-OLT4M28U3Z; OLT4M28U3Z; CHEMBL104070; [3-(trifluoromethyl)phenyl]methylphosphonic Acid; SCHEMBL8938031; ZINC1535206; BDBM50288667; 3-Trifluoromethylbenzylphosphonic acid; 3-(Trifluoromethyl)benzylphosphonic acid; (3-Trifluoromethyl-benzyl)-phosphonic acid; {[3-(Trifluoromethyl)phenyl]methyl}phosphonic acid; Q27285725
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| Activity |
IC50 = 88000 nM
|
[1] | |||
| Compound Name |
(1,2-Diphenyl-ethyl)-phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL53486; 1,2-diphenylethylphosphonic acid; BDBM50288664
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| Activity |
IC50 = 89000 nM
|
[1] | |||
| Compound Name |
(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107422; BDBM50288646
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|
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| Activity |
IC50 = 94000 nM
|
[1] | |||
| Compound Name |
[2-Phenyl-1-(3-trifluoromethyl-phenyl)-ethyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107540; BDBM50288650
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|
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
Benzhydrylphosphonic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
diphenylmethylphosphonic acid; Benzhydryl-phosphonic acid; (diphenylmethyl)phosphonic acid; CHEMBL106165; Oprea1_161449; SCHEMBL232244; CTK8A6895; ZINC2146584; BDBM50288647; MFCD00013952; Phosphonic acid, P-(diphenylmethyl)-; AKOS017344990
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|
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| Activity |
IC50 = 142000 nM
|
[1] | |||
| Compound Name |
[(4-Chloro-phenyl)-phenyl-methyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107348; BDBM50288654
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|
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| Activity |
IC50 = 143000 nM
|
[1] | |||
| Compound Name |
(Phenyl-p-tolyl-methyl)-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106241; SCHEMBL16859931; BDBM50288659; [(4-methylphenyl)-phenylmethyl]phosphonic acid
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|
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| Activity |
IC50 = 152000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
9h-Fluoren-9-ylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105772; FLUOREN-9-YL-PHOSPHONIC ACID; Phosphonic acid,9H-fluoren-9-yl- (9CI); NSC51302; SCHEMBL11412083; CTK5B9232; DTXSID60287476; ZINC1682479; (9H-Fluoren-9-yl)-phosphonic acid; BDBM50288645; MFCD08063241; NSC-51302; AKOS017344994
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|
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| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
Benzylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
Benzyl-phosphonic acid; Phosphonic acid, (phenylmethyl)-; phenylmethylphosphonic acid; Phosphonic acid, P-(phenylmethyl)-; Phenylmethanephosphonic acid; CHEMBL299737; Phenyl-methanephosphonic acid anion; MFCD00039519; Benzylphosphonic acid, 98%; AI3-22857; ACMC-1B2TF; alpha-Toluenephosphonic acid; Benzylphosphonic acid, 97%; SCHEMBL44318; BMK1-H2; DTXSID2064498; CTK3J2229; Phosphonic acid,P-(phenylmethyl)-; ZINC2168364; BDBM50080274; SBB057481; AKOS006221427; MCULE-2255375115; VZ31388; BP-21653; DB-022623; FT-0636281; ST51003159; 57717-EP2305682A1; 57717-EP2308879A1; Q27458263
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|
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| Activity |
IC50 > 500000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Benzylphosphonic acid inhibitors of human prostatic acid phosphatase. Bioorg Med Chem Lett. 1996 Feb 6;6(3):311-4. | ||||
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