Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93105 | Target Info | |||
| Target Name | Presenilin 1 (PSEN1) | ||||
| Synonyms |
S182 protein; Protein S182; Presenilin-1; PSNL1; PS1; PS-1; AD3
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PSEN1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[6-Chloro-9-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]carbazol-2-yl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2398572; BDBM50436208
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2,5,7,8-Tetramethyl-6-octoxy-3,4-dihydrochromene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2398575; BDBM50436216
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2,5,7,8-Tetramethyl-6-undecoxy-3,4-dihydrochromene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2398576; BDBM50436215
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Methyl 2-[[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl]oxy]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2398566; SCHEMBL16079258; BDBM50436219
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
DL-alpha-Tocopherol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
VITAMIN E; alpha-tochopherol; Ephanyl; all-rac-alpha-Tocopherol; (+-)-alpha-Tocopherol; UNII-7QWA1RIO01; 7QWA1RIO01; CHEMBL49563; .alpha.-Tocopherol; d-.alpha.-Tocopherol; Evitaminum; Profecundin; Syntopherol; Waynecomycin; Almefrol; Emipherol; Epsilan; Etamican; Tokopharm; Vascuals; Vitayonon; Etavit; Ilitia; Evion; alpha Tocopherol; Vitaplex E; Eprolin S; Spavit E; ido-E; Endo E; Vita E; Lan-E; Med-E; Antisterility vitamin; Tocopheroxy radical; Tocopheroxyl radical; alpha-Tocopherol, DL-; DL-all-rac-alpha-Tocopherol; SR-05000001813; CCRIS 5853; DL-Tocopherol; MFCD00072051; .alpha.-Tokoferol; .alpha. Tocopherol; DL-alpha tocopherol; EINECS 233-466-0; 5,8-Trimethyltocol; Vitamin E DL-alpha; Tocopherol (JP17); BRN 0094012; dl-.alpha.-Tocopherol; Spectrum_001195; DL-all-rac-A-Tocopherol; Spectrum2_000722; Spectrum3_001338; Spectrum4_001771; Spectrum5_000381; (??)-??-Tocopherol; DL-5,7,8-trimethyltocol; EC 233-466-0; SCHEMBL22303; BSPBio_003095; KBioGR_002282; KBioSS_001675; SPECTRUM310039; (all-R)-.alpha.-Tocopherol; 5-17-04-00168 (Beilstein Handbook Reference); DivK1c_000533; SPBio_000644; alpha-Tocopherol, >=95.5%; DTXSID8021355; SCHEMBL14315133; (.+-.)-Med-E; (.+/-.)-.alpha.-Tocopherol; HMS501K15; HSDB 8261; KBio1_000533; KBio2_001675; KBio2_004243; KBio2_006811; KBio3_002315; KS-00000VLH; (2R,8'R)-.alpha.-Tocopherol; DL-alpha-Tocopherol (Vitamin E); NINDS_000533; HMS1923I03; HMS2091C11; Pharmakon1600-00310039; C29H50O2 (DL-alpha-tocopherol); NSC20812; NSC82623; BBL027614; BDBM50436220; CCG-40162; NSC-20812; NSC-82623; NSC755839; s6104; SBB057399; STL372809; all-rac-alpha-Tocopherol (Vitamin E); AKOS015960364; DB14476; HY-W020044; MCULE-4241435740; NSC-755839; SDCCGMLS-0066634.P001; IDI1_000533; NCGC00095254-01; NCGC00095254-02; NCGC00095254-03; NCGC00095254-05; NCGC00095254-06; AC-10544; SY012869; SY057064; VS-08569; SBI-0051261.P003; AB0211519; A-Tocopherol; (+/-)-alpha-Tocopherol, analytical standard; CS-0031997; FT-0600386; FT-0624406; FT-0625430; FT-0696605; D02332; AB00051898_02; SR-05000001813-1; SR-05000001813-2; (+/-)-alpha-Tocopherol, synthetic, >=96% (HPLC); BRD-A82892199-001-01-7; Q27165663; F0001-2420; 7A4513C3-131C-41D4-B6A0-7ED994AC2947
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Membrane anchoring -secretase modulators with terpene-derived moieties. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3852-6. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.