Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92828 | Target Info | |||
| Target Name | Endothelin B receptor (EDNRB) | ||||
| Synonyms |
Endothelin receptor type B; Endothelin receptor Non-selective type; Endothelin receptor B; ETRB; ET-BR; ET-B
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| Target Type | Successful Target | ||||
| Gene Name | EDNRB | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 120 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
BMS-182874
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|
Terminated | Compound Info | ||
| Synonyms |
BMS-182874; Bms 182874; 5-Ddins; 153042-42-3; CHEMBL267458; 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide; 1-Naphthalenesulfonamide, 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-; Tocris-1441; AC1L3UAG; SCHEMBL802730; ZINC5803; CHEBI:92993; DTXSID60165205; BDBM50034435; NCGC00025164-01; LS-173440; L009159; BRD-K56509348-003-01-3; 5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide; 5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-dimethyl-2,3-dihydro-oxazol-5-yl)-amide
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
2''-[(Isobutyl-methyl-amino)-methyl]-4''-oxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL281869; SCHEMBL6642529; BDBM50122714
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
(2E,4E,6E)-Octa-2,4,6-trienoic acid (5R,9aS,9bS)-9b-hydroxy-6,6,9a-trimethyl-1-oxo-1,3,5,5a,6,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-5-yl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL173059; BDBM50088848
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(3-[1,3]dioxolan-2-yl-propyl)-pyrrolidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323175; BDBM50066411
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
GSK137647A; GSK 137647; GSK-137647A; N-mesityl-4-methoxybenzenesulfonamide; CHEMBL3311308; MFCD02007969; 4-methoxy-N-(2,4,6-trimethylphenyl)-benzenesulfonamide; CBMicro_012617; Oprea1_349531; Oprea1_545891; SCHEMBL19357604; KS-00000TIW; AOB2991; ZINC184126; BCP17136; EX-A1097; GSK 137647A; SMSF0014079; BDBM50044849; STK899558; AKOS003261220; CB15818; CS-5549; GSK-137647; MCULE-5583867808; N-mesityl-4-methoxy-1-benzenesulfonamide; NCGC00387253-02; NCGC00387253-05; AK240703; AS-16737; HY-19995; BIM-0012523.P001; FFA4 (GPR120) agonist GSK137647A; B7793; EU-0076636; FT-0700296; S0001; ST50719559; GSK137647A, >=98% (HPLC); A14542; AJ-292/14925630; SR-01000478738; J-690285; SR-01000478738-1; [(4-methoxyphenyl)sulfonyl](2,4,6-trimethylphenyl)amine; 4-methoxy-N-(2,4,6-trimethylphenyl)benzene-1-sulfonamide; 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
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| Activity |
EC50 ~ 50118.72 nM
|
[4] | |||
| Compound Name |
3-[(4-Chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(2,4-dimethoxyphenyl)thiophene-2-carboxamide;ethyl acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL43788
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| Activity |
IC50 = 51900 nM
|
[5] | |||
| Compound Name |
N-(3,4-Dimethyl-5-isoxazolyl)-4'-(2-thiazolyl)biphenyl-2-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL150260; SCHEMBL6641224; BDBM50109668; 4''-Thiazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-thiazol-2-yl)phenyl]benzenesulfonamide
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| Activity |
Ki = 52000 nM
|
[6] | |||
| Compound Name |
2-[(R)-1-((S)-2-Cyclohexylcarbamoyloxy-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-1H-imidazole-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL175228; BDBM50050058
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| Activity |
IC50 = 54000 nM
|
[7] | |||
| Compound Name |
2-[(3S,6S,9R,12R,15R)-6-(1H-Indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-thiophen-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL414165; BDBM50029353
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| Activity |
IC50 = 55000 nM
|
[8] | |||
| Compound Name |
[1,1'-Biphenyl]-2-sulfonamide, N-(3,4-dimethyl-5-isoxazolyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL310427; ACMC-20n6rd; SCHEMBL6151288; CTK0B1131; DTXSID80431691; BDBM50068700; L009620; Biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-phenylbenzenesulfonamide; N-(3,4-Dimethylisoxazol-5-yl)-[1,1'-biphenyl]-2-sulfonamide
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| Activity |
IC50 = 55000 nM
|
[9] | |||
| Compound Name |
3-(3-Methoxy-phenyl)-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL329861; SCHEMBL4631500; BDBM50288267; N-(4-bromo-3-methyl-1,2-oxazol-5-yl)-3-(3-methoxyphenyl)thiophene-2-sulfonamide
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| Activity |
IC50 = 56250 nM
|
[10] | |||
| Compound Name |
N-(3,4-Dimethyl-isoxazol-5-yl)-4-fluoro-benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL26522; SCHEMBL7860467; BDBM50034459; AKOS014824608; N-(3,4-dimethyl-1,2-oxazol-5-yl)-4-fluorobenzenesulfonamide
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| Activity |
IC50 = 57000 nM
|
[9] | |||
| Compound Name |
N-(3,4-Dimethyl-isoxazol-5-yl)-2,5-dimethyl-benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL80532; SCHEMBL7850030; BDBM50287993; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2,5-dimethylbenzenesulfonamide
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| Activity |
IC50 = 58000 nM
|
[9] | |||
| Compound Name |
5-Bromo-N-(3,4-dimethyl-isoxazol-5-yl)-2-methyl-benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL80180; BDBM50288053; AKOS014817508
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| Activity |
IC50 = 59000 nM
|
[9] | |||
| Compound Name |
3-(2-Methoxy-phenyl)-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL330003; SCHEMBL4631396; BDBM50288278; N-(4-bromo-3-methyl-1,2-oxazol-5-yl)-3-(2-methoxyphenyl)thiophene-2-sulfonamide
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| Activity |
IC50 = 59100 nM
|
[10] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-pent-4-enyl-pyrrolidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL110064; BDBM50066395
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
3-(2,4-Dimethyl-phenyl)-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89688; SCHEMBL4662705; BDBM50288263; N-(4-bromo-3-methyl-1,2-oxazol-5-yl)-3-(2,4-dimethylphenyl)thiophene-2-sulfonamide
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| Activity |
IC50 = 60300 nM
|
[10] | |||
| Compound Name |
N-(2-Carbamoyl-4,6-dimethoxyphenyl)-3-[(4-chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL297215; BDBM50058116
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| Activity |
IC50 = 61000 nM
|
[5] | |||
| Compound Name |
2-[(3S,6S,9R,12S,15R)-6-(1H-Indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL336033; ZINC4535642; BDBM50029352
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| Activity |
IC50 = 61000 nM
|
[8] | |||
| Compound Name |
3-[(4-Bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(2-methoxyphenyl)thiophene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL295207; SCHEMBL6151368; BDBM50058113; N-(2-Methoxyphenyl)-3-[(4-bromo-3-methylisoxazol-5-yl)sulfamoyl]-2-thiophenecarboxamide; 3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid (2-methoxy-phenyl)-amide
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| Activity |
IC50 = 61700 nM
|
[5] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2-[1,3]dioxan-2-yl-ethyl)-pyrrolidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL112877; BDBM50066393
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| Activity |
IC50 = 62000 nM
|
[1] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2,2-dimethyl-pentyl)-pyrrolidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL432974; SCHEMBL4998049; BDBM50066405
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| Activity |
IC50 = 62000 nM
|
[1] | |||
| Compound Name |
N-(4-Bromo-3-methyl-1,2-oxazol-5-yl)-3-(4-methoxyphenyl)thiophene-2-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL89689; BDBM50288274; 3-(4-Methoxy-phenyl)-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide
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| Activity |
IC50 = 62050 nM
|
[10] | |||
| Compound Name |
3-[(4-Bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(3-methoxyphenyl)thiophene-2-carboxamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL288967
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| Activity |
IC50 = 63100 nM
|
[5] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2,2,4-trimethyl-pent-3-enyl)-pyrrolidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL324586; BDBM50066397
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| Activity |
IC50 = 64000 nM
|
[1] | |||
| Compound Name |
3-Phenyl-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL88506; SCHEMBL6150893; BDBM50288261; N-(4-bromo-3-methyl-1,2-oxazol-5-yl)-3-phenylthiophene-2-sulfonamide
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| Activity |
IC50 = 64450 nM
|
[10] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-pyrrolidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL110053; SCHEMBL5003930; BDBM50066379
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| Activity |
IC50 = 65400 nM
|
[1] | |||
| Compound Name |
N-(3,4-Dimethyl-isoxazol-5-yl)-2-(1H-indol-2-yl)-benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL148967; SCHEMBL8345571; BDBM50068696; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-(1H-indol-2-yl)benzenesulfonamide; L019077
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| Activity |
Ki = 66000 nM
|
[11] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-pent-3-enyl-pyrrolidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL111218; BDBM50066408
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| Activity |
IC50 = 67000 nM
|
[1] | |||
| Compound Name |
3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid m-tolylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL48031; BDBM50058083; N-(3-Methylphenyl)-3-[(4-bromo-3-methylisoxazol-5-yl)sulfamoyl]-2-thiophenecarboxamide
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| Activity |
IC50 = 67400 nM
|
[5] | |||
| Compound Name |
N-(3-Hydroxyphenyl)-3-[(4-bromo-3-methylisoxazol-5-yl)sulfamoyl]-2-thiophenecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL48024; BDBM50058078; 3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid (3-hydroxy-phenyl)-amide
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| Activity |
IC50 = 67500 nM
|
[5] | |||
| Compound Name |
3-[(3,4-Dimethyl-1,2-oxazol-5-yl)sulfamoyl]-N-(4-methylphenyl)thiophene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL45456; SCHEMBL6151307; BDBM50058081; 3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid p-tolylamide; N-(4-Methylphenyl)-3-[(3,4-dimethylisoxazol-5-yl)sulfamoyl]-2-thiophenecarboxamide
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| Activity |
IC50 = 67600 nM
|
[5] | |||
| Compound Name |
3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid 2,4-dimethyl-phenyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL303203; SCHEMBL6150879; BDBM50289946; (2,4-dimethylphenyl) 3-[(4-chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylate
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| Activity |
IC50 = 68400 nM
|
[12] | |||
| Compound Name |
(2E,4E)-Hexa-2,4-dienoic acid (5R,9aS,9bS)-1,9b-dihydroxy-6,6,9a-trimethyl-1,3,5,5a,6,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-5-yl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL353502; BDBM50088850
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| Activity |
IC50 = 70000 nM
|
[3] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2-methyl-pentyl)-pyrrolidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL112417; BDBM50066410
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| Activity |
IC50 = 71000 nM
|
[1] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(3-ethyl-pentyl)-pyrrolidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL112770; BDBM50066409
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| Activity |
IC50 = 72000 nM
|
[1] | |||
| Compound Name |
3-Chloro-N-(3,4-dimethyl-isoxazol-5-yl)-2-methyl-benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL312551; SCHEMBL7860462; BDBM50288050; 3-chloro-N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-methylbenzenesulfonamide
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| Activity |
IC50 = 74000 nM
|
[9] | |||
| Compound Name |
2-Phenyl-thiophene-3-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL293232; SCHEMBL6151630; BDBM50288279; N-(4-bromo-3-methyl-1,2-oxazol-5-yl)-2-phenylthiophene-3-sulfonamide
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| Activity |
IC50 = 74100 nM
|
[10] | |||
| Compound Name |
N-(3,4-Dimethyl-5-isoxazolyl)-4'-(1,3,4-oxadiazole-2-yl)biphenyl-2-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL357077; SCHEMBL7939656; BDBM50109659; L016933; 4''-[1,3,4]Oxadiazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]benzenesulfonamide
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| Activity |
Ki = 75000 nM
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[6] | |||
| Compound Name |
N-Phenyl-3-[(4-bromo-3-methylisoxazol-5-yl)sulfamoyl]-2-thiophenecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL45269; SCHEMBL4632397; BDBM50058073; L012213; 3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid phenylamide; 3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-phenylthiophene-2-carboxamide
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| Activity |
IC50 = 77600 nM
|
[12] | |||
| Compound Name |
N-(3,4-Dimethyl-1,2-oxazol-5-yl)-2-[4-(1,3-oxazol-5-yl)phenyl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL107574; SCHEMBL6639015; BDBM50091109; 4'-(Oxazole-5-yl)-N-(3,4-dimethyl-5-isoxazolyl)biphenyl-2-sulfonamide; 4''-Oxazol-5-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide
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| Activity |
Ki = 78000 nM
|
[13] | |||
| Compound Name |
2-[(R)-1-((S)-2-Cyclohexyloxycarbonyloxy-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL368629; BDBM50050064
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| Activity |
IC50 = 79000 nM
|
[7] | |||
| Compound Name |
2,5-Dichloro-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL311455; BDBM50287999; AB00038921-01
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| Activity |
IC50 = 80000 nM
|
[9] | |||
| Compound Name |
3-[(4-Bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(6-oxo-1H-pyridazin-3-yl)thiophene-2-carboxamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL44615
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| Activity |
IC50 = 81400 nM
|
[5] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-[2-(2-oxo-piperidin-1-yl)-ethyl]-pyrrolidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL109478; SCHEMBL14202334; BDBM50066380
Click to Show/Hide
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||||
| Activity |
IC50 = 85000 nM
|
[1] | |||
| Compound Name |
N-(3,4-Dimethyl-isoxazol-5-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL312670; N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide; SCHEMBL7716850; BDBM50288010; N-(3,4-Dimethyl-5-isoxazolyl)benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 88000 nM
|
[9] | |||
| Compound Name |
2-[(R)-1-[[(S)-2-[[[Cyclohexyl(methyl)amino]carbonyl]oxy]-4-methylpentanoyl]amino]-2-(1-methyl-1H-indol-3-yl)ethyl]-5-methyloxazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL175698; BDBM50050063
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[7] | |||
| Compound Name |
2-[(R)-1-[(S)-2-(2-Cyclohexyl-acetylamino)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-1H-imidazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL174871; BDBM50050057
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 90000 nM
|
[7] | |||
| Compound Name |
3-Chloro-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76360; BDBM50288039
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[9] | |||
| Compound Name |
3-[(4-Chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(5-methyl-1,2-oxazol-3-yl)thiophene-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL48120
Click to Show/Hide
|
||||
| Activity |
IC50 = 92100 nM
|
[5] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-((Z)-2,2-dimethyl-pent-3-enyl)-pyrrolidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323951; BDBM50066372
Click to Show/Hide
|
||||
| Activity |
IC50 = 92700 nM
|
[1] | |||
| Compound Name |
N-(3,4-Dimethyl-1,2-oxazol-5-yl)-2-[4-(5-methyl-1,3-oxazol-4-yl)phenyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104172; SCHEMBL6639627; BDBM50091106; 4''-(5-Methyl-oxazol-4-yl)-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide; 4'-(5-Methyloxazole-4-yl)-N-(3,4-dimethyl-5-isoxazolyl)biphenyl-2-sulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki = 94000 nM
|
[13] | |||
| Compound Name |
4'-(Benzoxazole-2-yl)-N-(3,4-dimethyl-5-isoxazolyl)biphenyl-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319036; BDBM50091100; 4''-Benzooxazol-2-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide
Click to Show/Hide
|
||||
| Activity |
Ki = 94000 nM
|
[13] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2-propyl-pentyl)-pyrrolidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111023; BDBM50066392
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[1] | |||
| Compound Name |
3-p-Tolyl-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91073; BDBM50288271
Click to Show/Hide
|
||||
| Activity |
IC50 = 95550 nM
|
[10] | |||
| Compound Name |
N-Benzyl-3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL417358; SCHEMBL4631818; BDBM50058090; 3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid benzylamide; N-Benzyl-3-[(4-bromo-3-methylisoxazol-5-yl)sulfamoyl]-2-thiophenecarboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 97700 nM
|
[5] | |||
| Compound Name |
Cyclo(D-Glu-Ala-D-Val-Leu-D-Trp)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3349461; CHEMBL69761; SCHEMBL2695532; BDBM50000740; cyclo(-D-Glu-L-Ala-D-Val-L-Leu-D-Trp-); cyclo(-D-Trp1-D-Glu2-Ala3-D-Val4-Leu5-)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-(4-Bromo-3-methyl-5-isoxazolyl)-2-thiophenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91470; SCHEMBL4631417; BDBM50288276; N-(4-bromo-3-methyl-5-isoxazolyl)thiophene-2-sulfonamide; N-(4-bromo-3-methyl-1,2-oxazol-5-yl)thiophene-2-sulfonamide; Thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-[(3S,6R,9S,12S,15S)-6-(1H-Indol-3-ylmethyl)-10-methyl-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307324; BDBM50000739
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-[(1,1-dioxothiazinan-2-yl)methyl]pyrrolidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL113589; BDBM50066386
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2-oxazol-2-yl-ethyl)-pyrrolidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322732; SCHEMBL14203390; BDBM50066406
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[(3S,6R,9S,12S,15S)-6-(1H-Indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304756; BDBM50000736
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Methyl 3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65531; SCHEMBL4631503; BDBM50289933; N-(4-Bromo-3-methyl-5-isoxazolyl)-2-(carbomethoxy)thiophene-3-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[2-(1,3-Benzodioxol-5-yl)-1-(dimethylamino)ethyl]-N-(4-chloro-3-methyl-1,2-oxazol-5-yl)thiophene-3-sulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL416453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazine-1-carbonyl)-thiophene-3-sulfonic acid (4-chloro-3-methyl-isoxazol-5-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL296427; SCHEMBL6151635; BDBM50058142
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
2-[(R)-1-((S)-2-Cyclohexyloxycarbonylamino-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL353320; SCHEMBL9113645; BDBM50050060
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-[(R)-1-[(S)-2-(3-Cyclohexyl-3-methyl-ureido)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL174699; SCHEMBL9111546; BDBM50050059
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Methyl 3-(N-(4-chloro-3-methylisoxazol-5-yl)sulfamoyl)thiophene-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63169; Methyl 3-[(4-chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylate; C10H9ClN2O5S2; SCHEMBL5208967; CTK8C2412; DTXSID00445891; BCP12516; 9655AA; ANW-68354; BDBM50289934; ZINC26187857
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid 2,4-dimethyl-phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65488; SCHEMBL6151654; BDBM50289941; (2,4-dimethylphenyl) 3-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-o-Tolyl-thiophene-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313551; SCHEMBL4631577; BDBM50288270; N-(4-bromo-3-methyl-1,2-oxazol-5-yl)-3-(2-methylphenyl)thiophene-2-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-[(R)-1-[(S)-2-(3-Cyclohexyl-1-methyl-ureido)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-1H-imidazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL367033; SCHEMBL9113205; BDBM50050055
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64006; SCHEMBL3634612; BDBM50289930; 3-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylic Acid; AKOS014824029
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(4-Chloro-3-methyl-5-isoxazolyl)-2-[(2-methyl-1,3,4-thiadiazol-5-yl)aminocarbonyl]thiophene-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL297048; SCHEMBL6152565; BDBM50058098
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid (6-acetyl-benzo[1,3]dioxol-5-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL295583; SCHEMBL5211709; BDBM50058102
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-[(4-Bromo-3-methylisoxazol-5-yl)sulfamoyl]-2-thiophenecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL297107; SCHEMBL4631365; BDBM50058094; 3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxamide; N-(4-bromo-3-methyl-5-isoxazolyl)-2-(aminocarbonyl)thiophene-3-sulfonamide; 3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
[(3R,6S,9R,12S,15R)-6-(1H-Indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]methanesulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL342615; BDBM50029351
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2-[1,3]dioxolan-2-yl-2-methyl-propyl)-pyrrolidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111611; SCHEMBL14229621; BDBM50066378
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid o-tolyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63805; SCHEMBL6151568; BDBM50289947; (2-methylphenyl) 3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid p-tolyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL66641; SCHEMBL6151327; BDBM50289932; (4-methylphenyl) 3-[(4-chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid phenylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65407; SCHEMBL6151342; BDBM50289937; 3-[(4-chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-phenylthiophene-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[(R)-1-[(S)-2-(3-Cyclohexyl-1-methyl-ureido)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL369821; SCHEMBL9110687; BDBM50050052
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-(2-Benzo[1,3]dioxol-5-yl-1-hydroxy-1-methyl-ethyl)-thiophene-3-sulfonic acid (4-chloro-3-methyl-isoxazol-5-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL46195; SCHEMBL4632108; BDBM50058128
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
2-[(R)-1-((R)-2-Cyclohexylcarbamoylmethyl-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL177839; BDBM50050054
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
5-Benzyloxy-3-isopropoxy-benzo[b]thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL10143; SCHEMBL8023421; BDBM50287187; 5-phenylmethoxy-3-propan-2-yloxy-1-benzothiophene-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-[(R)-1-((R)-2-Cyclohexylcarbamoylmethyl-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-1H-imidazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL366805; BDBM50050061
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291891; SCHEMBL6150873; BDBM50289931; phenyl 3-[(4-chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[(R)-1-[(S)-2-(2-Cyclohexyl-acetylamino)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL177179; BDBM50050053
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-[2-(tetrahydro-pyran-4-yl)-ethyl]-pyrrolidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109474; BDBM50066390
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[(4-Bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-methyl-N-phenylthiophene-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL47536
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-(4-Bromo-3-methyl-5-isoxazolyl)thiophene-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL265290; SCHEMBL6150870; BDBM50288269; N-(4-bromo-3-methyl-1,2-oxazol-5-yl)thiophene-3-sulfonamide; Thiophene-3-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-[(R)-1-((S)-2-Cyclohexyloxycarbonylamino-4-methyl-pentanoylamino)-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-1H-imidazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL367645; SCHEMBL9112294; BDBM50050062
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid phenylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304481; SCHEMBL6151684; BDBM50289944; 3-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]-N-phenylthiophene-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63611; SCHEMBL6151554; BDBM50289926; phenyl 3-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[(R)-1-[(S)-2-(3-Cyclohexyl-ureido)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL441112; SCHEMBL9283409; BDBM50050042
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid m-tolyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291404; SCHEMBL6152463; BDBM50289935; (3-methylphenyl) 3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL434983; SCHEMBL4663316; BDBM50289927; 3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylic Acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid p-tolyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63938; SCHEMBL8502911; BDBM50289939
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(4-Bromo-3-methyl-isoxazol-5-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78080; SCHEMBL7228721; BDBM50288024; N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide; N-(4-bromo-3-methyl-1,2-oxazol-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
3-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65639; SCHEMBL3802024; BDBM50289938; Methyl 3-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylate; N-(3,4-dimethyl-5-isoxazolyl)-2-(carbomethoxy)thiophene-3-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-[2-(tetrahydro-furan-2-yl)-ethyl]-pyrrolidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321831; BDBM50066373
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(N-(4-Chloro-3-methylisoxazol-5-yl)sulfamoyl)thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Thiophenecarboxylicacid, 3-[[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl]-; CHEMBL67664; 3-(N-(4-Chloro-3-methylisoxazol-5-yl)sulfamoyl)-thiophene-2-carboxylic acid; 3-[(4-chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylic Acid; SCHEMBL2842500; CTK8C2411; DTXSID20445212; BCP12517; CS-M1004; KS-00000QK0; 9628AA; ANW-68353; BDBM50289942; MFCD18642943; ZINC13815570; AKOS015909969; AK-79759; [(4-chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylic acid; 3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid; 3-[(4-chloro-3-methyl-5-isoxazolyl)sulfamoyl]-2-thiophenecarboxylic acid; N-(4-chloro-3-methyl-5-isoxazolyl)-3-sulfamoyl-2-thiophenecarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[(2S,5S,8S,11S,14R)-14-(1H-Indol-3-ylmethyl)-5-methyl-11-(2-methylpropyl)-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302776; BDBM50000733
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-[(3S,6S,9S,12R,15S)-12-(1H-Indol-3-ylmethyl)-6-methyl-2,5,8,11,14-pentaoxo-3-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-9-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308208; BDBM50000734
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-[(2S,5S,8S,11S,14R)-8-[(2R)-Butan-2-yl]-14-(1H-indol-3-ylmethyl)-5-methyl-11-(2-methylpropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1790499; BDBM50368323
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-(3,4-Dimethyl-1,2-oxazol-5-yl)-2-[4-(4-methyl-1,3-oxazol-2-yl)phenyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104223; SCHEMBL6640784; BDBM50091108; 4''-(4-Methyl-oxazol-2-yl)-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide; 4'-(4-Methyloxazole-2-yl)-N-(3,4-dimethyl-5-isoxazolyl)biphenyl-2-sulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[13] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-[2-(2,5-dioxo-pyrrolidin-1-yl)-ethyl]-pyrrolidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322799; SCHEMBL14203773; BDBM50066387
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-(4-Bromo-3-methyl-5-isoxazolyl)-2-biphenylsulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80857; SCHEMBL6152569; BDBM50288038; ZINC01540808; L012210; Biphenyl-2-sulfonic acid (4-bromo-3-methyl-isoxazol-5-yl)-amide; N-(4-bromo-3-methyl-1,2-oxazol-5-yl)-2-phenylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-{[3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carbonyl]-amino}-3,5-dimethoxy-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL296074; BDBM50058087
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(2-[1,3]dioxolan-2-yl-ethyl)-pyrrolidine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323989; BDBM50066399
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304406; SCHEMBL6151615; BDBM50289928; phenyl 3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-[(2S,5R,8S,11R,14S)-8-[(2S)-Butan-2-yl]-14-(1H-indol-3-ylmethyl)-5-methyl-11-(2-methylpropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL343379; BDBM50029355
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-{[3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carbonyl]-amino}-3,5-dimethoxy-benzoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL295632; BDBM50058074
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thiophene-2-carboxylic acid o-tolylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL47450; SCHEMBL6151267; BDBM50058096; N-(2-Methylphenyl)-3-[(4-bromo-3-methylisoxazol-5-yl)sulfamoyl]-2-thiophenecarboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2,4-Dichloro-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79054; SCHEMBL7858808; BDBM50287998; 2,4-dichloro-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 105000 nM
|
[9] | |||
| Compound Name |
N-(3,4-Dimethyl-1,2-oxazol-5-yl)-2-[4-(2-methyl-1,3-oxazol-4-yl)phenyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106846; SCHEMBL6640821; BDBM50091099; 4''-(2-Methyl-oxazol-4-yl)-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide; 4'-(2-Methyloxazole-4-yl)-N-(3,4-dimethyl-5-isoxazolyl)biphenyl-2-sulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki = 110000 nM
|
[13] | |||
| Compound Name |
Acetic acid;3-[[3-[(4-bromo-3-methyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carbonyl]amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL47008
Click to Show/Hide
|
||||
| Activity |
IC50 = 117000 nM
|
[5] | |||
| Compound Name |
N-(3,4-Dimethyl-5-isoxazolyl)-4'-(1-methyl-2-imidazolyl)biphenyl-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL149010; SCHEMBL6640136; BDBM50109672; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1-methylimidazol-2-yl)phenyl]benzenesulfonamide; 4''-(1-Methyl-1H-imidazol-2-yl)-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide
Click to Show/Hide
|
||||
| Activity |
Ki = 120000 nM
|
[6] | |||
| Compound Name |
N-(3,4-Dimethyl-5-isoxazolyl)-4'-(4-pyrimidinyl)biphenyl-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL346862; SCHEMBL8573377; BDBM50109660; L015406; 4''-Pyrimidin-4-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-(4-pyrimidin-4-ylphenyl)benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki = 130000 nM
|
[6] | |||
| Compound Name |
N-(3,4-Dimethyl-5-isoxazolyl)-4'-(2-imidazolyl)biphenyl-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL148855; SCHEMBL6642013; BDBM50109661; 4''-(1H-Imidazol-2-yl)-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-[4-(1H-imidazol-2-yl)phenyl]benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki = 150000 nM
|
[6] | |||
| Compound Name |
N-(3,4-Dimethyl-5-isoxazolyl)-4'-(5-pyrimidinyl)biphenyl-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL149340; SCHEMBL8566691; BDBM50109665; L015408; 4''-Pyrimidin-5-yl-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-(4-pyrimidin-5-ylphenyl)benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki = 170000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 12 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(3,4-Dimethyl-isoxazol-5-yl)-2-thiophen-2-yl-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL357789; SCHEMBL7946124; BDBM50068712; L019069; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-thiophen-2-ylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[11] | |||
| Compound Name |
N-(3,4-Dimethyl-isoxazol-5-yl)-2-thiophen-3-yl-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151819; SCHEMBL7951249; BDBM50068718; L019070; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-thiophen-3-ylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[11] | |||
| Compound Name |
N-(3,4-Dimethyl-isoxazol-5-yl)-2-pyrimidin-2-yl-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL357678; SCHEMBL8347975; BDBM50068737; L019075; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-pyrimidin-2-ylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[11] | |||
| Compound Name |
N-(3,4-Dimethyl-5-isoxazolyl)-4'-(1H-tetrazole-5-yl)biphenyl-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL149778; BDBM50109669; 4''-(1H-Tetrazol-5-yl)-biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[6] | |||
| Compound Name |
N-(3,4-Dimethyl-isoxazol-5-yl)-2-(1H-indol-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL357331; SCHEMBL8347916; BDBM50068679; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-(1H-indol-3-yl)benzenesulfonamide; L019073
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[11] | |||
| Compound Name |
N-(3,4-Dimethyl-isoxazol-5-yl)-2-pyridin-3-yl-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL148637; SCHEMBL8350252; BDBM50068708; L019076; N-(3,4-dimethyl-1,2-oxazol-5-yl)-2-pyridin-3-ylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[11] | |||
| Compound Name |
Acridin-9-yl-benzo[1,3]dioxol-5-yl-acetic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320236; BDBM50288537; L012657
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[17] | |||
| Compound Name |
3-Benzo[1,3]dioxol-5-yl-5-ethoxy-1-(4-methoxy-benzyl)-1H-indole-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL55621; BDBM50289729
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000 nM
|
[18] | |||
| Compound Name |
3-[(4-Chloro-3-methyl-1,2-oxazol-5-yl)sulfamoyl]-N-(4-methyl-1,3-benzodioxol-5-yl)thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45296; BDBM50058134
Click to Show/Hide
|
||||
| Activity |
IC50 = 355500 nM
|
[15] | |||
| Compound Name |
(5S,6R,7R)-5-(3,4-Dimethoxyphenyl)-4-methoxy-6,7-bis(methoxymethyl)-5,6,7,8-tetrahydrobenzo[f][1,3]benzodioxole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Nirtetralin; CHEMBL453822; BDBM50292476; ZINC38940226
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[19] | |||
| Compound Name |
4-[(2R,3R)-3-[(3,4-Dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-1,2-dimethoxybenzene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL453568; (2R,3R)-Phyllanthin; SCHEMBL503799; MEGxp0_001857; ZINC5879645; BDBM50292477; MCULE-1843058440; Phyllanthin from the plant phyllanthus amarus
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[19] | |||
| Compound Name |
Hypophyllanthin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC 619044; CHEMBL510130; DTXSID50187355; BDBM50292475; ZINC15778313; AKOS032948633; W1812; A1-06838; Q27253693; UNII-22ZZ21E33P component LBJCUHLNHSKZBW-XGHQBKJUSA-N
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[19] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546). J Med Chem. 1998 Aug 13;41(17):3261-75. | ||||
| REF 2 | Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003 Jan 2;46(1):125-37. | ||||
| REF 3 | Synthesis and endothelin receptor binding activity of synthetic analogues of RES-1149-2. Bioorg Med Chem Lett. 2000 May 1;10(9):895-7. | ||||
| REF 4 | Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3. | ||||
| REF 5 | Structure-activity relationships of N2-aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides as selective endothelin receptor-A antagonists. J Med Chem. 1997 May 23;40(11):1682-9. | ||||
| REF 6 | Biphenylsulfonamide endothelin receptor antagonists. Part 3: structure-activity relationship of 4'-heterocyclic biphenylsulfonamides. Bioorg Med Chem Lett. 2002 Feb 25;12(4):517-20. | ||||
| REF 7 | Azole endothelin antagonists. 3. Using delta log P as a tool to improve absorption. J Med Chem. 1996 Feb 16;39(4):982-91. | ||||
| REF 8 | Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists. J Med Chem. 1995 Oct 13;38(21):4309-24. | ||||
| REF 9 | Halogen substitution at the isoxazole ring enhances the activity of N-(isoxazolyl)sulfonamide endothelin antagonists. Bioorg Med Chem Lett. 1996 Oct 22;6(20):2393-8. | ||||
| REF 10 | Thiophenesulfonamides as endothelin receptor antagonists. Bioorg Med Chem Lett. 1996 Nov 19;6(22):2651-6. | ||||
| REF 11 | Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308). J Med Chem. 1998 Dec 17;41(26):5198-218. | ||||
| REF 12 | 2-Aryloxycarbonylthiophene-3-sulfonamides: Highly potent and etA selective endothelin receptor antagonists. Bioorg Med Chem Lett. 1997 Aug 19;7(16):2093-8. | ||||
| REF 13 | Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET... J Med Chem. 2000 Aug 10;43(16):3111-7. | ||||
| REF 14 | Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications. J Med Chem. 1992 May 29;35(11):2139-42. | ||||
| REF 15 | Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist. J Med Chem. 1997 May 23;40(11):1690-7. | ||||
| REF 16 | 1-benzyl-3-thioaryl-2-carboxyindoles as potent non-peptide endothelin antagonists. Bioorg Med Chem Lett. 1996 Jun 18;6(12):1367-70. | ||||
| REF 17 | Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists. Bioorg Med Chem Lett. 1996 Dec 17;6(24):2999-3002. | ||||
| REF 18 | 1,4-Diaryl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acids as endothelin receptor antagonists. Bioorg Med Chem Lett. 1997 Jul 22;7(14):1883-6. | ||||
| REF 19 | A Novel Class of Non-Peptidic Endothelin Antagonists Isolated from the Medicinal Herb Phyllanthus niruri. J Nat Prod. 1995;58(10):1515-20. | ||||
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