Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92640 | Target Info | |||
| Target Name | Lysophosphatidic acid receptor 1 (LPAR1) | ||||
| Synonyms |
Lysophosphatidic acid receptor Edg-2; LPA1; LPA-1; LPA receptor 1; EDG2; EDG 2 receptor
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | LPAR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
LPA2 antagonist 1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL256470; VC-6664; BCP11072; BDBM50373826; MFCD25976928; ZINC29126798; NCGC00390601-01; HY-18075
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
7-Methyl-N-[(2S)-1-[4-(2-methylphenyl)piperazin-1-yl]propan-2-yl]thieno[3,2-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404452; BDBM50373817
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[4-[[(3,5-Dimethoxybenzoyl)-(3-phenylpropyl)amino]methyl]phenoxy]benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL272087; SCHEMBL707253; BDBM50373831
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(Cyclopentylamino)-2-(2,4-dimethoxyphenyl)-1H-imidazo[1,2-b]pyrazole-7-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1394166; SCHEMBL15518354; HMS1857G07; ZINC6768565; BDBM50023478; CCG-81688; MCULE-8745632514; NCGC00120003-01; SR-01000100900; SR-01000100900-1; E002-0885
Click to Show/Hide
|
||||
| Activity |
IC50 = 800000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41. | ||||
| REF 2 | Discovery of novel non-carboxylic acid 5-amino-4-cyanopyrazole derivatives as potent and highly selective LPA1R antagonists. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4450-4454. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.