Target Poor or Non Binder(s) Information

Target General Information

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Target ID

T92521

Target Info

Target Name

Cytochrome P450 1B1 (CYP1B1)

Synonyms

CYPIB1

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Target Type

Clinical trial Target

Gene Name

CYP1B1

Biochemical Class

Paired donor oxygen oxidoreductase

UniProt ID

Q16678

Poor Binders of This Target (in total, 9 binders)

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Compound Name

Estrone

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Approved

Compound Info

Synonyms

Aquacrine; Crinovaryl; Cristallovar; Crystogen; Destrone; Disynformon; Endofolliculina; Esterone; Estrin; Estrol; Estron; Estrona; Estronum; Estrovarin; Estrugenone; Estrusol; Femidyn; Fermidyn; Folikrin; Folipex; Folisan; Follestrine; Follestrol; Folliculin; Folliculine; Follicunodis; Glandubolin; Hiestrone; Hormestrin; Hormofollin; Hormovarine; Kestrone; Ketodestrin; Ketohydroxyestrin; Ketohydroxyoestrin; Ketophydroxyestrin; Kolpon; Menagen; Menformon; Mestronaq; OESTRONE; Oestrin; Oestroform; Oestronum; Oestroperos; Ovifollin; Perlatan; Solliculin; Theelin; Thelestrin; Thelykinin; Thynestron; Tokokin; Unden; Unigen; Wehgen; Wynestron; Estrogenic Substance; Estrona [Spanish]; Femestrone injection; Follicular hormone; Folliculine benzoate; Hauck Brand of Estrone; Hyrex Brand of Estrone; Menformon A; Oestrone [Steroidal oestrogens]; Penncap M; Vortech Brand of Estrone; WynestronPencap M; CMC_13458; E 9750; E0026; E(sub 1); Estrona [INN-Spanish]; Estrone (E1); Estrone (TN); Estrone [USAN:INN]; Estrone-A; Estronum [INN-Latin]; Femestrone inj.; Ketohydroxy-Estratriene; NATURAL ESTROGENIC SUBSTANCE-ESTRONE; Oestrone, Estrone; Ovex (tablets); Unden (pharmaceutical); Unden (pharmaceutical) (VAN); Estrone (JAN/USP/INN); Estrone, (8 alpha)-Isomer; Estrone, (9 beta)-Isomer; Estrone, (+-)-Isomer; [2,4,6,7-3H]-E1; Delta-1,3,5-Estratrien-3beta-ol-17-one; Delta-1,3,5-Oestratrien-3beta-ol-17-one; Delta-1,3,5-estratrien-3-beta-ol-17-one; Delta-1,3,5-oestratrien-3-beta-ol-17-one; (13S)-3-hydroxy-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one; (8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one; 1,3,5(10)-Estratrien-3-ol-17-one; 1,3,5(10)-Oestratrien-3-ol-17-one; 3-Hydroxy-1,3,5(10)-estratrien-17-one; 3-Hydroxy-17-keto-estra-1,3,5-triene; 3-Hydroxy-17-keto-oestra-1,3,5-triene; 3-Hydroxy-oestra-1,3,5(10)-trien-17-one; 3-Hydroxyestra-1,3,5(10)-trien-17-one; 3-Hydroxyestra-1,3,5(10)-triene-17-one; 3-hydroxy-estra-1,3,5(10)-trien-17-one

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IC50 ~ 50000 nM

[1]

Compound Name

Estradiol

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Approved

Compound Info

Synonyms

Aerodiol; Alora; Altrad; Aquadiol; Bardiol; Climaderm; Climara; Compudose; Corpagen; Dermestril; Destradiol; Dihydrofolliculin; Dihydromenformon; Dihydrotheelin; Dihydroxyesterin; Dihydroxyestrin; Dihydroxyoestrin; Dimenformon; Diogyn; Diogynets; Divigel; Elestrin; Encore; Esclim; Estrace; Estraderm; Estradiolo; Estradiolum; Estradot; Estraldine; Estrasorb; Estreva; Estrifam; Estring; Estroclim; Estrodiolum; Estrogel; Estrovite; Evamist; Evorel; Extrasorb; Femanest; Femestral; Femestrol; Fempatch; Femtran; Follicyclin; Gelestra; Ginedisc; Ginosedol; GynPolar; Gynergon; Gynestrel; Gynodiol; Gynoestryl; Innofem; Lamdiol; Macrodiol; Macrol; Menest; Menorest; Microdiol; Nordicol; Oesclim; Oestergon; Oestradiol; Oestradiolum; Oestrogel; Oestroglandol; Oestrogynal; Ovahormon; Ovasterol; Ovastevol; Ovociclina; Ovocyclin; Ovocycline; Ovocylin; Perlatanol; Polyestradiol; Primofol; Profoliol; Progynon; Syndiol; Systen; Tradelia; Trocosone; Vagifem; Vivelle; Zerella; Zesteem; Zesteen; Zumenon; Climara Forte; Component of Menrium; Estraderm MX; Estraderm TTS; Estradiolo [DCIT]; Estradiolum [INN]; Estring vaginal ring; Estrofem Forte; Oestradiol Berco; Oestradiol R; Progynon DH; Sandrena Gel; Sisare Gel; Trial SAT; CMC_11154; Compudose 200; Compudose 365; E 2; E 8875; E0025; Epiestriol 50; Estraderm TTS 100; Estraderm TTS 50; Estrapak 50; Estroclim 50; Estrofem 2; Sandrena 1; [3H]]estradiol; Activella (TN); Alora (TN); Alpha-Oestradiol; AngeliQ (TN); B-Estradiol; Beta-Estradiol; Beta-Oestradiol; Beta-estradiol; Cis-Estradiol; Cis-Oestradiol; Climara (TN); D-Estradiol; D-Oestradiol; Divigel (TN); E(sub 2); Elestrin (TN); Estrace (TN); Estraderm (TN); Estraderm TTS (TN); Estradiol [USAN:INN]; Estradiol acetate (TN); Estradiol cypionate (TN); Estradiol valerate (TN); Estradiol-17 beta; Estradiol-17beta; Estrasorb (TN); Estrasorb Topical (TN); Estring (TN); Estrofem (TN); Estrogel (TN); EvaMist (TN); Femring (TN); Innofem (TN); Menostar (TN); Oestradiol-17beta; Progynon-DH; Progynova (TN); S-21400; SK-Estrogens; SL-1100; VIVELLE-DOT; Vagifem (TN); Vivelle (TN); [3H]-estradiol; Estradiol-17-beta; Estradiol-3,17beta; Oestradiol-17-beta; Vivelle-Dot (TN); D-3,17beta-Estradiol; [2,4,6,7-3H]-E2; 17 beta-Estradiol; 17-.BETA.-Estradiol; 17-beta-OH-estradiol; 17-beta-estradiol; 17.beta.-Estradiol; 17.beta.-Oestradiol; 17b-Oestradiol; 17beta oestradiol; 17beta-Estradiol; 17beta-Oestradiol; 3,17-beta-Estradiol; 3,17-beta-Oestradiol; 3,17.beta.-Estradiol; 3,17beta-Estradiol

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IC50 ~ 50000 nM

[1]

Compound Name

Resveratrol

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Phase 3

Compound Info

Synonyms

Resveratrol; Resvida; KUC104385N; R 5010; SRT 501; Cis-resveratrol; PREVENTION 8 (RESVERATROL); RM-1812; SRT-501; Trans-resveratrol; CU-01000001503-3; KSC-10-164; Resveratrol-3-sulfate; Trans-3,4',5-trihydroxystilbene; Trans-3,4′,5-Trihydroxystilbene; Trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene; (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol

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Activity

IC50 = 55000 nM

[2]

Compound Name

ALPHA-NAPHTHOFLAVONE

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Investigative

Compound Info

Synonyms

7,8-Benzoflavone; alpha-Naphthoflavone; 604-59-1; 2-Phenyl-4H-benzo[h]chromen-4-one; alpha-Naphthylflavone; 2-phenylbenzo[h]chromen-4-one; Benzo(h)flavone; 7,8-BF; 4H-Naphtho[1,2-b]pyran-4-one, 2-phenyl-; .alpha.-Naphthoflavone; 2-Phenyl-benzo[h]chromen-4-one; 2-Phenyl-4H-naphtho(1,2-b)pyran-4-one; CCRIS 3607; 2-Phenylbenzo(h)chromen-4-one; EINECS 210-071-1; UNII-FML65D8PY5; NSC 407011; BRN 0210862; FML65D8PY5; benzo[h]flavone; MLS003171601; CHEMBL283196; CHEBI:76995; VFMMPHCGEFXGIP-UHFFFAOYSA-N; 4H-NAPHTHO(1,2-b)PYRAN-4-ONE, 2-PH

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Activity

IC50 ~ 50000 nM

[3]

Compound Name

2-[2-[2-[2-[2-(3-Fluorophenyl)-6,7,10-trimethoxy-4-oxobenzo[h]chromen-3-yl]oxyethoxy]ethoxy]ethoxy]ethyl 2-aminoacetate;hydrochloride

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Investigative

Compound Info

Synonyms

CHEMBL3422358

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Activity

IC50 = 51200 nM

[4]

Compound Name

2-[3,4-Bis(phenylmethoxy)phenyl]-6,7,10-trimethoxybenzo[h]chromen-4-one

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Investigative

Compound Info

Synonyms

CHEMBL3422344; BDBM50081739

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Activity

IC50 ~ 100000 nM

[4]

Compound Name

4-Aminobenzoic acid

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Investigative

Compound Info

Synonyms

p-aminobenzoic acid; para-aminobenzoic acid; AMINOBENZOIC ACID; Vitamin BX; p-Carboxyaniline; 4-Carboxyaniline; Sunbrella; Benzoic acid, 4-amino-; p-Carboxyphenylamine; Hachemina; Paraminol; 1-Amino-4-carboxybenzene; Pabacyd; Pabafilm; Pabamine; Paranate; Amben; Potaba; Romavit; Bacterial vitamin H1; Vitamin H'; Anticanitic vitamin; Chromotrichia factor; RVPaba Lipstick; Papacidum; Rvpaba; Trichochromogenic factor; Anti-chromotrichia factor; Super Shade by Coppertone; Benzoic acid, p-amino-; Acidum paraminobenzoicum; Pabagel; Pabanol; 4-AMINO-BENZOIC ACID; Caswell No. 033B; Kyselina p-aminobenzoova; MFCD00007894; Vitamin H1; p-Aminobenzoesaeure; 4-Aminobenzoesaeure; 4-aminobenzoic-acid; 4-Carboxyphenylamine; Acido p-aminobenzoico; gamma-Aminobenzoic acid; benzoic acid, 4-amino; Acido p-aminobenzoico [Italian]; UNII-TL2TJE8QTX; Kyselina p-aminobenzoova [Czech]; para-aminobenzoate; Anticantic vitamin; EPA Pesticide Chemical Code 233300; BRN 0471605; p-amino benzoic acid; p-amino-Benzoic acid; AI3-02436; TL2TJE8QTX; Aminobenzoic acid (USP); Aminobenzoic acid [USP]; .gamma.-Aminobenzoic acid; Aniline-4-carboxylic acid; CHEMBL542; 4-Aminobenzoic acid, 99%; H-4-ABZ-OH; AMINOBENZOIC ACID, PARA; NCGC00091051-01; 4-aminobenzoicacid; DSSTox_CID_4466; DSSTox_RID_77411; DSSTox_GSID_24466; SMR000471833; CCRIS 6209; HSDB 6840; NSC 7627; EINECS 205-753-0; Actipol; p-carboxy aniline; p-aminobezoic acid; gamma-Aminobenzoate; 4-aminobezoic acid; Trochromogenic factor; Aniline-4-carboxylate; 4-Amino benzoic acid; 4-(amino)benzoic acid; Antichromotrichia factor; PubChem13422; Spectrum_000036; RVPaba lipstick (TN); P-AMINO-BENZOATE; Aminobenzoic Acid, USP; Spectrum2_000123; Spectrum3_000294; Spectrum4_000142; Spectrum5_000778; Tetracaine EP Impurity A; P-Aminobenzoic Acid,(S); ACMC-209d3t; bmse000066; bmse000887; bmse000916; Epitope ID:115017; H-(4)Abz-OH; AMINOBENZOIC-4 ACID; EC 205-753-0; SCHEMBL8249; Oprea1_221096; BSPBio_001828; KBioGR_000584; KBioSS_000396; ZINC920; KSC176C0R; MLS001066325; MLS001335919; MLS001335920; Para Amino Benzoic Acid USP; BIDD:ER0375; DivK1c_000783; SPBio_000166; PARA AMINO BENZOIC ACID; RARECHEM AL BO 0238; component of Presun (Salt/Mix); DTXSID6024466; SCHEMBL13232108; CTK0H6108; KBio1_000783; KBio2_000396; KBio2_002964; KBio2_005532; KBio3_001328; NSC7627; NINDS_000783; OTAVA-BB 1509951; P-AMINOBENZOIC ACID 100G; 150-13-0 4-aminobenzoic acid; HMS2269E10; HMS3870E13; LABOTEST-BB LTBB000459; WT266; ACT09225; HY-B1008; NSC-7627; Tox21_111069; Tox21_201702; Tox21_300087; ANW-21255; BDBM50145829; LABOTEST-BB LT03328355; s4510; SBB058665; STK397441; AKOS000118983; Tox21_111069_1; AC-8107; AM86626; AS00762; CCG-266139; CS-4505; DB02362; MCULE-3535374816; IDI1_000783; KS-0000022O; 4-Aminobenzoic acid, analytical standard; NCGC00091051-02; NCGC00091051-03; NCGC00091051-04; NCGC00253923-01; NCGC00259251-01; AK-41178; AS-12493; NCI60_041683; SC-18898; SY003749; SBI-0051277.P003; DB-028695; 4-Aminobenzoic acid, ReagentPlus(R), 99%; A0269; FT-0617557; ST50632536; 4-Aminobenzoic acid, >=98.0% (HPLC/NT); 3297-EP2308861A1; 3297-EP2308868A1; 3297-EP2311809A1; 4-Aminobenzoic acid, ReagentPlus(R), >=99%; 6761-EP1441224A2; 6761-EP2295402A2; C00568; D02456; Q-9193; 48316-EP2281563A1; 48316-EP2308874A1; 48316-EP2311494A1; Q284959; 4-Aminobenzoic acid, Vetec(TM) reagent grade, 98%; Q-200432; Z57127446; 4-Aminobenzoic acid, 98.5-100.2%, SAJ first grade; F2191-0259; 4A5E7DD8-8A22-4642-86BF-05B778C0C78E

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IC50 ~ 120000 nM

[2]

Compound Name

4-Methoxyestradiol

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Investigative

Compound Info

Synonyms

4-methoxy-17beta-estradiol; 4-Methoxyestradiol-17beta; 4-MeOE2; CHEMBL4084860; 4-Methoxy-3,17beta-dihydroxy-1,3,5[10]-estratriene; 4-methoxy-estradiol; 4-Methoxy 17beta-estradiol; SCHEMBL2596534; DTXSID50949596; ZINC5764434; BDBM50252402; 4-methoxy-estra-1,3,5(10)-triene-3beta-ol; 4-Methoxyestra-1,3,5(10)-triene-3,17-diol; 4-Methoxy-1,3,5[10]-estratriene-3,17beta-diol; 4-methoxyestra-1,3,5(10)-triene-3,17beta-diol; 3,17beta-dihydroxy-4-methoxy-1,3,5[10]-estratriene; (17beta)-4-methoxyestra-1,3,5(10)-triene-3,17-diol; 3,4,17beta-trihydroxy-1,3,5[10]-estratriene 4-methyl ether; Estra-1,3,5(10)-triene-3,17-diol, 4-methoxy-, (17beta)-

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Activity

Ki = 149000 nM

[5]

Compound Name

4-[(e)-Phenyldiazenyl]morpholine

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Investigative

Compound Info

Synonyms

NSC136065; MLS002920350; CHEMBL3814820; (Morpholinoazo)benzene; CTK2F6983; CTK8D5306; DTXSID60300336; BDBM50179288; ZINC12403044; MORPHOLIN-4-YL-PHENYL-DIAZENE; ZINC100367003; NSC-136065; SMR001797943

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Activity

IC50 = 163000 nM

[2]

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Non Binders of This Target (in total, 5 non binders)

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Compound Name

Testosterone

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Approved

Compound Info

Synonyms

AndroGel; Androderm; Androlin; Andronaq; Andropatch; Androsorb; Andrusol; Depotest; Halotensin; Homosteron; Homosterone; Intrinsa; LibiGel; Malerone; Mertestate; Neotestis; Oreton; Orquisteron; Perandren; Primotest; Primoteston; Relibra; Striant; Sustanon; Sustanone; Teslen; Testandrone; Testaqua; Testiculosterone; Testim; Testobase; Testoderm; Testogel; Testolin; Testopropon; Testosteroid; Testosteron; Testosterona; Testosteronum; Testostosterone; Testoviron; Testrone; Testryl; Virormone; Virosterone; Beta testosterone; Cristerona T; Cristerone T; Malogen in Oil; Oreton F; Percutacrine androgenique; Synandrol F; Testoderm Tts; Testopel Pellets; Testosterone and its esters; Testosterone hydrate; Testosterone solution; Testoviron Schering; Testoviron T; Testro AQ; Virilon IM; AA 2500; Andro 100; Andronate 100; Andronate 200; Andropository 200; Andryl 200; CDB 111C; CMC_13449; COL 1621; CP 601B; Everone 200; Sustason 250; Testamone 100; Testred Cypionate 200; Androderm (TN); Androgel (TN); Geno-cristaux gremy; Malestrone (amps); Malogen, aquaspension injection; Neo-Hombreol F; Neo-testis; Oreton-F; Scheinpharm Testone-Cyp; Striant (TN); T-Cypionate; Testim (TN); Testoject-50; Testosterona [INN-Spanish]; Testosterone [Androgenic steroids, anabolic]; Testosterone [INN:BAN]; Testosteronum [INN-Latin]; Trans-Testosterone; Testosterone (JAN/USP); Testrin-P.A; Delta4-Androsten-17beta-ol-3-one; Delta4-androsten-17b-ol-3-one; Androst-4-en-17beta-ol-3-one; Delta(sup 4)-Androsten-17(beta)-ol-3-one; (17beta)-17-Hydroxyandrost-4-en-3-one; (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one; 17-Hydroxy-(17-beta)-androst-4-en-3-one; 17-Hydroxy-(17beta)-androst-4-en-3-one; 17-Hydroxy-4-androsten-3-one; 17-beta-Hydroxy-delta(sup 4)-androsten-3-one; 17-beta-Hydroxyandrost-4-en-3-one; 17b-hydroxy-4-androsten-3-one; 17beta-Hydroxy-3-oxo-4-androstene; 17beta-Hydroxy-4-androsten-3-one; 17beta-Hydroxy-delta(sup4)-androsten-3-one; 17beta-Hydroxyandrost-4-en-3-one; 17beta-Hydroxyandrost-4-ene-3-one; 4-Androsten-17-ol-3-one; 4-Androsten-17beta-ol-3-one; 4-androstene-17beta-ol-3-one; 7-beta-Hydroxyandrost-4-en-3-one

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Activity

Ki = 411800 nM

[5]

Compound Name

Fluoxetine

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Phase 3 Trial

Compound Info

Synonyms

Fluoxetin; Pulvules; Portal; Eufor; Animex-On; Fluoxetina; Fluoxetina [Spanish]; Fluoxetinum; Fluoxetinum [INN-Latin]; Fluoxetina [INN-Spanish]

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Activity

IC50 = 475000 nM

[5]

Compound Name

Furafylline

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Investigative

Compound Info

Synonyms

3-Furfuryl-1,8-dimethylxanthine; UNII-C2087G0XX3; 3-(furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H,7H)-dione; 3-(2-Furanylmethyl)-3,7-dihydro-1,8-dimethyl-1H-purine-2,6-dione; 3-(furan-2-ylmethyl)-1,8-dimethyl-7H-purine-2,6-dione; CHEMBL405845; C2087G0XX3; NCGC00015426-04; DSSTox_CID_25153; DSSTox_RID_80707; DSSTox_GSID_45153; Furafylline [INN]; Furafilina [Spanish]; Furafyllinum [Latin]; Furafilina; Furafyllinum; Furafilina;Furafyllinum; Lopac-F-124; Lopac0_000538; SCHEMBL191214; DTXSID2045153; CTK5E7657; Furafylline, >=98% (HPLC); HMS2089A08; HMS3261L17; BCP20952; ZINC9227032; Tox21 110143; Tox21_110143; Tox21_500538; BDBM50236897; MFCD00153799; AKOS027380039; Tox21_110143_1; CCG-204628; LP00538; SDCCGSBI-0050521.P002; NCGC00015426-01; NCGC00015426-02; NCGC00015426-03; NCGC00015426-05; NCGC00015426-06; NCGC00015426-07; NCGC00015426-08; NCGC00015426-09; NCGC00015426-14; NCGC00093927-01; NCGC00093927-02; NCGC00093927-03; NCGC00093927-04; NCGC00261223-01; AC-32562; BS-17557; HY-107204; CS-0027630; EU-0100538; F-124; A17085; BIM-0050521.0001; AB01275435-01; SR-01000076233; Q5509469; SR-01000076233-1; 3-(2-furfuryl)-1,8-dimethyl-7H-purine-2,6-quinone; 3-(2-furylmethyl)-1,8-dimethyl-7H-purine-2,6-dione; 3-(uran-2-ylmethyl)-1,8-dimethyl-7H-purine-2,6-dione; 3-(furan-2-ylmethyl)-1,8-dimethyl-3,7-dihydro-1H-purine-2,6-dione

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Activity

Ki > 200000 nM

[6]

Compound Name

4-[(E)-Morpholin-4-yldiazenyl]benzoic acid

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Investigative

Compound Info

Synonyms

CHEMBL3814999; MLS000554526; 4-(Morpholin-4-ylazo)-benzoic acid; 4-(morpholin-4-yldiazenyl)benzoic acid; CHEMBL1465824; HMS2537F20; ZINC306208; BDBM50179355; STK055807; AKOS005386503; MCULE-4390158640; SMR000171588; ST50976323; SR-01000314333; SR-01000314333-1

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Activity

IC50 = 400000 nM

[2]

Compound Name

Bergamottin

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Investigative

Compound Info

Synonyms

Bergamotin; Bergamotine; 5-Geranoxypsoralen; Bergaptin; 5-Geranyloxypsoralen; Bergomottin; UNII-JMU611YFRB; JMU611YFRB; 4-[(2E)-3,7-dimethylocta-2,6-dienoxy]furo[3,2-g]chromen-7-one; CHEMBL1078442; 4-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-7H-furo[3,2-g][1]benzopyran-7-one; Bergaptol geranyl ether; CCRIS 8085; SCHEMBL569529; SCHEMBL7183139; Bergamottin, analytical standard; DTXSID50897528; HY-N2194; TNP00285; ZINC1658570; BDBM50310823; MFCD00017409; NSC710599; AKOS000277132; NSC-710599; NCGC00017345-01; NCGC00161832-01; B3943; CS-0019502; A16907; C22152; 380B407; Q568006; (E)-4-(3,7-dimethylocta-2,6-dienyloxy)-7H-furo[3,2-g]chromen-7-one; 4-([(2E)-3,7-dimethyl-2,6-octadienyl]oxy)-7h-furo[3,2-g]chromen-7-one; 4-{[(2E)-3,7-Dimethylocta-2,6-dien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one; 7H-Furo(3,2-g)(1)benzopyran-7-one, 4-((3,7-dimethyl-2,6-octadienyl)oxy)-, (E)-

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Activity

Ki = 587000 nM

[5]

References

Top

REF 1

Targeting cytochrome P450 (CYP) 1B1 with steroid derivatives. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5272-5276.

REF 2

Aryl morpholino triazenes inhibit cytochrome P450 1A1 and 1B1. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3243-3247.

REF 3

Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. Eur J Med Chem. 2017 Mar 31;129:159-174.

REF 4

Design and Synthesis of New alpha-Naphthoflavones as Cytochrome P450 (CYP) 1B1 Inhibitors To Overcome Docetaxel-Resistance Associated with CYP1B1 Overexpression. J Med Chem. 2015 Apr 23;58(8):3534-47.

REF 5

Inhibitors of cytochrome P450 (CYP) 1B1. Eur J Med Chem. 2017 Jul 28;135:296-306.

REF 6

A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2. J Med Chem. 2015 Aug 27;58(16):6481-93.

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