Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92460 | Target Info | |||
| Target Name | Guanine deaminase (GDA) | ||||
| Synonyms |
p51-nedasin; KIAA1258; Guanine aminohydrolase; Guanase; GAH
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| Target Type | Literature-reported Target | ||||
| Gene Name | GDA | ||||
| Biochemical Class | Metallo-dependent hydrolase superfamily. ATZ/TRZ family | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
6-(Hydroxymethyl)-1,4,6,7-tetrahydroimidazo[4,5-e][1,4]diazepine-5,8-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL220699; BDBM50193756; 4,5,7,8-tetrahydro-6-hydroxymethyl-6H-imidazo[4,5-e][1,4]diazepine-5,8-dione
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| Activity |
Ki = 53600 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-Benzyl-3H-imidazo[4,5-e][1,4]diazepine-6,8-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL120006; BDBM50073384; 3-Benzylimidazo[4,5-e][1,4]diazepine-6,8(3H,7H)-dione
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| Activity |
Ki = 227000 nM
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[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design of inhibitors against guanase: synthesis and biochemical evaluation of analogues of azepinomycin. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5551-4. | ||||
| REF 2 | Synthesis and guanase inhibition studies of a novel ring-expanded purine analogue containing a 5:7-fused, planar, aromatic heterocyclic ring system. Bioorg Med Chem Lett. 1998 Dec 15;8(24):3649-52. | ||||
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