Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92458 | Target Info | |||
| Target Name | Cytochrome P450 24 (CYP24A1) | ||||
| Synonyms |
Vitamin D(3) 24hydroxylase; Cytochrome P450CC24; CYP24A1; 24OHase; 1,25dihydroxyvitamin D(3) 24hydroxylase, mitochondrial
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| Target Type | Clinical trial Target | ||||
| Gene Name | CYP24A1 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Benzyl-N-(2-(1H-imidazol-1-yl)-2-phenylethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171107; BDBM50322356
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| Activity |
IC50 = 72000 nM
|
[1] | |||
| Compound Name |
(E)-2-(Biphenyl-2-ylmethylene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1253779; BDBM50326838
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| Activity |
IC50 = 111100 nM
|
[2] | |||
| Compound Name |
2-Bromo-Benzylidene Tetralone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL363682; ZINC4826285; BDBM50155468; UPCMLD0ENAT5390543:001; NCGC00324208-01; NCGC00324208-02; AB01318957-03; AB01318957-04; (2E)-2-(2-bromobenzylidene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one; 2-[1-(2-bromophenyl)methylidene]-6-methoxy-3,4-dihydro-2H-naphthalen-1-one
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| Activity |
IC50 = 122000 nM
|
[2] | |||
| Compound Name |
2-(Biphenyl-2-ylmethyl)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1253947; BDBM50326839
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| Activity |
IC50 = 127600 nM
|
[2] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(2-(E)-Styrylbenzyl)-6-methoxy-tetralone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254040; BDBM50326840
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| Activity |
IC50 = 342800 nM
|
[2] | |||
| Compound Name |
(2E)-6-Methoxy-2-(2-methylbenzylidene)-3,4-dihydronaphthalen-1(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL188017; ZINC214496; BDBM50155472; 6-Methoxy-2-[1-o-tolyl-meth-(E)-ylidene]-3,4-dihydro-2H-naphthalen-1-one; 6-methoxy-2-[1-(2-methylphenyl)methylidene]-3,4-dihydro-2H-naphthlalen-1-one
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| Activity |
IC50 = 480100 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides. Bioorg Med Chem. 2010 Jul 15;18(14):4939-46. | ||||
| REF 2 | Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones. Eur J Med Chem. 2010 Oct;45(10):4427-34. | ||||
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