Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T91661 | Target Info | |||
| Target Name | Adenosine kinase (ADK) | ||||
| Synonyms |
Adenosine 5'-phosphotransferase; AK
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| Target Type | Clinical trial Target | ||||
| Gene Name | ADK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 20 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-Phenyl-6-thia-10b-aza-benzo[e]azulen-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
NSC675284; CHEMBL32718; 6-phenylpyrrolo[2,1-d][1,5]benzothiazepin-7-one; 6-phenylpyrrolo[2,1-d][1,5]benzothiazepin-7(6h)-one; AC1L8OAU; 5-Phenyl-6-thia-10b-aza-benzo[e]azulen-4-one; CTK8D2539; BDBM50041512; NSC-675284
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| Activity |
IC50 = 130000 nM
|
[1] | |||
| Compound Name |
Chembl4209197
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456508
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4212073
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456514
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4204838
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456513
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4213595
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456505
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4215567
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456511
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
Chembl4217077
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456506
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4217051
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456523
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4204332
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456516
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4214720
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL6904568; BDBM50456504; 6-naphthalen-1-ylpyrrolo[2,1-d][1,5]benzothiazepin-7-one; (+/-)-6-(1-naphthyl)pyrrolo[2,1-d][1,5]benzothiazepin-7(6H)-one
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4203924
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456507
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| Activity |
IC50 = 57400 nM
|
[2] | |||
| Compound Name |
5-Ethyl-5-p-tolyl-6-oxa-10b-aza-benzo[e]azulen-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL342620; BDBM50082063; (+/-)-6-ethyl-6-(p-tolyl)pyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one; 5-(4-Methylphenyl)-5-ethyl-6-oxa-10b-azabenzo[e]azulene-4(5H)-one
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| Activity |
IC50 = 80000 nM
|
[1] | |||
| Compound Name |
6-Ethyl-6-phenyl-pyrrolo[2,1-d][1,5]benzoxazepin-7-one
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Investigative | Compound Info | ||
| Synonyms |
NSC676419; CHEMBL329653; CTK8D2536; DTXSID70327670; BDBM50052046; Deriv of pyrrolobenzoxazepinones (PBO); NSC-676419; 5-Ethyl-5-phenyl-6-oxa-10b-aza-benzo[e]azulen-4-one; 5-Phenyl-5-ethyl-6-oxa-10b-azabenzo[e]azulene-4(5H)-one; 6-ethyl-6-phenylpyrrolo[2,1-d][1,5]benzoxazepin-7(6h)-one; (+/-)-6-Ethyl-6-phenylpyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one
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| Activity |
IC50 = 85000 nM
|
[1] | |||
| Compound Name |
6-Phenylpyrrolo[2,1-d][1,5]benzoxazepin-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL327869; SCHEMBL4263273; CTK7H0984; BDBM50052061; 5-Phenyl-6-oxa-10b-aza-benzo[e]azulen-4-one; 5-Phenyl-6-oxa-10b-azabenzo[e]azulene-4(5H)-one; 6-phenylpyrrolo[2,1-d][1,5]benzoxazepin-7(6h)-one; (+/-)-6-Pyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
[5-(6-Amino-9-phenethyl-9H-purin-8-yl)-furan-2-yl]-phosphonic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL519503; BDBM50277972
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
5-(4-Amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]imidazol-2-yl)furan-2-ylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL570790; SCHEMBL4129250; BDBM50303854; [5-[4-amino-7-ethyl-5-fluoro-1-(2-methylpropyl)benzimidazol-2-yl]furan-2-yl]phosphonic acid
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
5-(6-Amino-9-neopentyl-9H-purin-8-yl)furan-2-ylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482735; SCHEMBL13741964; BDBM50277565; {5-[6-Amino-9-(2,2-dimethyl-propyl)-9H-purin-8-yl]-furan-2-yl}-phosphonic Acid
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
6-Ethyl-6-(m-tolyl)pyrrolo[2,1-d][1,5]benzoxazepin-7-one
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Investigative | Compound Info | ||
| Synonyms |
NSC694755; CHEMBL139532; CTK8C8761; BDBM50082057; NSC-694755; 5-Ethyl-5-m-tolyl-6-oxa-10b-aza-benzo[e]azulen-4-one; (+/-)-5-ethyl-5-m-tolyl-6-oxa-10b-aza-benzo[e]azulen-4-one; 6-Ethyl-6-(m-tolyl)-pyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one; 5-(3-Methylphenyl)-5-ethyl-6-oxa-10b-azabenzo[e]azulene-4(5H)-one; 6-ethyl-6-(3-methylphenyl)pyrrolo[2,1-d][1,5]benzoxazepin-7(6h)-one
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| Activity |
IC50 = 150000 nM
|
[1] | |||
| Compound Name |
6-Ethyl-6-[4-[[3-(2-pyrrolidin-1-ylethyl)phenoxy]methyl]phenyl]pyrrolo[2,1-d][1,5]benzoxazepin-7-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688587; BDBM50339504
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| Activity |
IC50 = 150000 nM
|
[1] | |||
| Compound Name |
6-[4-[[3-[2-(Diethylamino)ethyl]phenoxy]methyl]phenyl]-6-ethylpyrrolo[2,1-d][1,5]benzoxazepin-7-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688586; BDBM50339503
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| Activity |
IC50 = 200000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 49 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
10-(Dimethylamino)-6-phenylpyrrolo[2,1-d][1,5]benzothiazepin-7-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688495; BDBM50339511; (+/-)-10-(dimethylamino)-6-phenylbenzo[b]pyrrolo[1,2-d][1,4]thiazepin-7(6H)-one
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
(3R,4S,5R)-2-(4-Amino-5-methylpyrrolo[2,3-d]pyrimidin-7-yl)-5-methyloxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611878
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|
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| Activity |
IC50 = 60255958.61 nM
|
[5] | |||
| Compound Name |
2-(4-Amino-5-methyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318634; BDBM50090851; (2R,3R,4S,5R)-2-(4-Amino-5-methyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol
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| Activity |
IC50 = 60603820.05 nM
|
[6] | |||
| Compound Name |
7-[(3R,4S,5R)-3,4-Dihydroxy-5-methyloxolan-2-yl]-5-iodo-1H-pyrrolo[2,3-d]pyrimidine-4-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608627
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| Activity |
IC50 = 154881661.9 nM
|
[5] | |||
| Compound Name |
2-(4-Amino-5-methylsulfanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL317927; BDBM50090841
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| Activity |
IC50 = 740798339.2 nM
|
[6] | |||
| Compound Name |
(3R,4S,5R)-2-(4-Amino-5-methylsulfanylpyrrolo[2,3-d]pyrimidin-7-yl)-5-methyloxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL610114
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| Activity |
IC50 = 741310241.3 nM
|
[5] | |||
| Compound Name |
2-(4-Amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methoxymethyl-tetrahydro-furan-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL322217; BDBM50090865
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| Activity |
IC50 = 831763771.1 nM
|
[5] | |||
| Compound Name |
2-Hydroxymethyl-5-(5-iodo-4-methylamino-pyrrolo[2,3-d]pyrimidin-7-yl)-tetrahydro-furan-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL319177; SCHEMBL17800832; BDBM50090848; 5-Iodo-4-methylamino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
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| Activity |
IC50 = 831763771.1 nM
|
[5] | |||
| Compound Name |
4-Amino-7-(3,4-dihydroxy-5-methyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95256; BDBM50090846; 4-Amino-7-(5-deoxy-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid ethyl ester
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| Activity |
IC50 = 1000000000 nM
|
[6] | |||
| Compound Name |
Ethyl 4-amino-7-[(3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL608926
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|
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| Activity |
IC50 = 1000000000 nM
|
[5] | |||
| Compound Name |
(3R,4S,5R)-2-(4-Chloro-5-methylpyrrolo[2,3-d]pyrimidin-7-yl)-5-methyloxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL608326
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| Activity |
IC50 = 1862087137 nM
|
[5] | |||
| Compound Name |
2-(4-Chloro-5-methyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99662; BDBM50090840; (2R,3R,4S,5R)-2-(4-Chloro-5-methyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol
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| Activity |
IC50 = 1868959972 nM
|
[6] | |||
| Compound Name |
(3R,4S,5R)-2-(4-Amino-5-bromopyrrolo[2,3-d]pyrimidin-7-yl)-5-ethyloxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL611870
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| Activity |
IC50 = 1995262315 nM
|
[5] | |||
| Compound Name |
2-(4-Amino-5-bromo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-ethyl-tetrahydro-furan-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL95721; BDBM50090856; (2R,3R,4S,5R)-2-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-ethyl-tetrahydrofuran-3,4-diol; (2R,3R,4S,5R)-2-(4-Amino-5-bromo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-ethyl-tetrahydro-furan-3,4-diol
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| Activity |
IC50 = 1999861870 nM
|
[6] | |||
| Compound Name |
Sangivamycin
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Investigative | Compound Info | ||
| Synonyms |
7-Deazaadenosine-7-carboxamide; UNII-L8YQ8Z3T9T; L8YQ8Z3T9T; Antibiotic B-14437; CHEMBL101892; NSC-65346; 4-Amino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)pyrimidine-5-carboxamide; B-14437; 4-amino-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide; 7-Deaza-7-carbamoyladenosine; BRN 0626355; Sanzivamycin; Sangivamycin, hydrochloride; 7H-Pyrrolo[2,3-d]pyrimidine-5-carboxamide, 4-amino-7-.beta.-D-ribofuranosyl-; cid_5153; BIDD:GT0419; SCHEMBL195540; ZINC4217438; BDBM50049820; 7H-Pyrrolo(2,3-d)pyrimidine-5-carboxamide, 4-amino-7-beta-D-ribofuranosyl-; BA-90912; J-011802; Q27158840; 4-Amino-5-carboxamide-7-(D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine; 4-amino-7-(beta-d-ribofuranosyl)-7h-pyrrolo[2,3-d]pyrimidine-5-carboxamide
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| Activity |
IC50 = 2127649080 nM
|
[6] | |||
| Compound Name |
4-Amino-7-(3,4-dihydroxy-5-methyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL98638; 5'-Deoxysangivamycin; BDBM50090836
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| Activity |
IC50 = 2172701179 nM
|
[6] | |||
| Compound Name |
4-Amino-7-[(3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL611551
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|
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| Activity |
IC50 = 2187761624 nM
|
[5] | |||
| Compound Name |
2-(4-Chloro-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methoxymethyl-tetrahydro-furan-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99359; BDBM50090838
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| Activity |
IC50 = 2238721139 nM
|
[5] | |||
| Compound Name |
Toyocamycin
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Investigative | Compound Info | ||
| Synonyms |
Siromycin; Cyanotubericidin; Ahygroscopin-B; Vengicide; Uramycin B; 7-Deaza-7-cyanoadenosine; Antibiotic E212; Unamycin B; Antibiotic 1037; Antibiotic A-399-Y4; Naritheracin; NSC 63701; NSC 99843; UNII-L7995C4D7F; Unamycin-B; A-399-Y4; E-212; 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H-pyrrolo(2,3-d)pyrimidine; 4-Amino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)pyrimidine-5-carbonitrile; CHEMBL99668; L7995C4D7F; 4-Amino-5-cyano-7-(beta-d-ribofuranosyl)pyrrolo[2,3-d]pyrimidine; E-212-1; 4-amino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile; 4-Amino-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile; BRN 0048454; toyocamicin; Ara-toyocamycine; Vengicide; Toyocamycin; Neuro 000027; 4-26-00-01419 (Beilstein Handbook Reference); SCHEMBL336095; cid_247955; ZINC4217594; BDBM50049823; 7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-beta-D-ribofuranosyl-; DB13916; HY-103248; CS-0026179; Q27282806; Toyocamycin, >=98% (HPLC), from Streptomyces rimosus; 4-Aminopyrrolo[2,3-d]pyrimidine-5-carbonitrile 7-(beta-D-ribofuranoside); 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile,4-amino-7-b-D-ribofuranosyl-; {7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile,} 4-amino-7-.beta.-D-ribofuranosyl-
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| Activity |
IC50 = 3228494122 nM
|
[6] | |||
| Compound Name |
5'-Deoxytoyocamycin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99388; SCHEMBL6877410; DTXSID60984150; BDBM50090861; 4-Amino-7-(5-deoxypentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
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| Activity |
IC50 = 3228494122 nM
|
[6] | |||
| Compound Name |
4-Amino-7-[(3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611270
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| Activity |
IC50 = 3235936569 nM
|
[5] | |||
| Compound Name |
5-Chlorotubercidin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL98933; NSC 124149; SCHEMBL20938332; BDBM50090857; 7H-Pyrrolo(2,3-d)pyrimidin-4-amine, 5-chloro-7-beta-D-ribofuranosyl-
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| Activity |
IC50 = 4764309868 nM
|
[6] | |||
| Compound Name |
5-Bromotubercidin
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Investigative | Compound Info | ||
| Synonyms |
Bromotubercidin; Tubercidin, 5-bromo-; CHEMBL62099; 7H-Pyrrolo(2,3-d)pyrimidin-4-amine, 5-bromo-7-beta-D-ribofuranosyl-; NSC103802; 5-Bromotubericidin; SCHEMBL2786440; CTK9A5769; ZINC5161614; BDBM50000300; MFCD22124434; AKOS030228349; NSC 103802
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| Activity |
IC50 = 8317637711 nM
|
[5] | |||
| Compound Name |
2-Azidomethyl-5-(5-bromo-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-tetrahydro-furan-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99119; BDBM50090859; 7-(5-Azido-5-deoxy-beta-D-ribofuranosyl)-5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
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| Activity |
IC50 = 10000000000 nM
|
[6] | |||
| Compound Name |
2-(4-Amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-vinyl-tetrahydro-furan-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL97553; BDBM50090837; 7-(5-Methylene-5-deoxy-beta-D-ribofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (2R,3R,4S,5R)-2-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-vinyl-tetrahydrofuran-3,4-diol; (2R,3R,4S,5R)-2-(4-Amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-vinyl-tetrahydro-furan-3,4-diol
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||||
| Activity |
IC50 = 10000000000 nM
|
[5] | |||
| Compound Name |
(2R,3S,4R)-2-(Azidomethyl)-5-(5-bromo-4-chloropyrrolo[2,3-d]pyrimidin-7-yl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608925
Click to Show/Hide
|
||||
| Activity |
IC50 = 10000000000 nM
|
[5] | |||
| Compound Name |
(3R,4S,5R)-2-(4-Chloro-5-methylsulfanylpyrrolo[2,3-d]pyrimidin-7-yl)-5-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611873
Click to Show/Hide
|
||||
| Activity |
IC50 = 14125375446 nM
|
[5] | |||
| Compound Name |
2-(4-Chloro-5-methylsulfanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318056; BDBM50090866; 7-(5-Deoxy-beta-D-ribofuranosyl)-5-(methylthio)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 14285649814 nM
|
[6] | |||
| Compound Name |
(3R,4S,5R)-2-(4-Amino-5-bromopyrrolo[2,3-d]pyrimidin-7-yl)-5-(azidomethyl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL609519
Click to Show/Hide
|
||||
| Activity |
IC50 = 15848931925 nM
|
[5] | |||
| Compound Name |
2-(4-Amino-5-bromo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-azidomethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97437; BDBM50090860; 7-(5-Azido-5-deoxy-beta-D-ribofuranosyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 15874497983 nM
|
[6] | |||
| Compound Name |
(3R,4S,5R)-2-(4-Amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-ethyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611869
Click to Show/Hide
|
||||
| Activity |
IC50 = 16595869074 nM
|
[5] | |||
| Compound Name |
2-(4-Amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-ethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97494; BDBM50090864; 7-(5,6-Dideoxy-beta-D-ribo-hexofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (2R,3R,4S,5R)-2-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-ethyl-tetrahydrofuran-3,4-diol; (2R,3R,4S,5R)-2-(4-Amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-ethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
||||
| Activity |
IC50 = 16664795936 nM
|
[6] | |||
| Compound Name |
(3R,4S,5R)-2-(5-Bromo-4-chloropyrrolo[2,3-d]pyrimidin-7-yl)-5-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608043
Click to Show/Hide
|
||||
| Activity |
IC50 = 19952623150 nM
|
[5] | |||
| Compound Name |
2-(5-Bromo-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98910; SCHEMBL8325888; BDBM50090852; 7-(5-Deoxy-beta-D-ribofuranosyl)-5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine; (2R,3R,4S,5R)-2-(5-Bromo-4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
||||
| Activity |
IC50 = 19998618696 nM
|
[6] | |||
| Compound Name |
2-(5-Iodo-4-methylsulfanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95481; BDBM50090855; 7-(5-Deoxy-beta-D-ribofuranosyl)-5-iodo-4-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 22222862543 nM
|
[6] | |||
| Compound Name |
(3R,4S,5R)-2-(5-Iodo-4-methylsulfanylpyrrolo[2,3-d]pyrimidin-7-yl)-5-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL612198
Click to Show/Hide
|
||||
| Activity |
IC50 = 22387211386 nM
|
[5] | |||
| Compound Name |
2-(4-Amino-5-bromo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98909; 5-Bromo-5'-deoxytubercidin; BDBM50090847; (2R,3R,4S,5R)-2-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydrofuran-3,4-diol; (2R,3R,4S,5R)-2-(4-Amino-5-bromo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
||||
| Activity |
IC50 = 24997697022 nM
|
[6] | |||
| Compound Name |
2-(4-Amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-azidomethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318043; BDBM50090863; 7-(5-Azido-5-deoxy-beta-D-ribofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 28569326346 nM
|
[6] | |||
| Compound Name |
(3R,4S,5R)-2-(4-Amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-(azidomethyl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL612193
Click to Show/Hide
|
||||
| Activity |
IC50 = 28840315031 nM
|
[5] | |||
| Compound Name |
(2R,3R,4S,5R)-2-(4-Chloro-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328824; SCHEMBL4019484; BDBM50090853; 4-Chloro-5-iodo-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine; 7-(beta-D-Ribofuranosyl)-5-iodo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine; 7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-5-iodo-7-beta-D-ribofuranosyl-
Click to Show/Hide
|
||||
| Activity |
IC50 = 41667745222 nM
|
[6] | |||
| Compound Name |
2-Azidomethyl-5-(4-chloro-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL449407; BDBM50090854; 7-(5-Azido-5-deoxy-beta-D-ribofuranosyl)-5-iodo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.11E+11 nM
|
[6] | |||
| Compound Name |
(2R,3S,4R)-2-(Azidomethyl)-5-(4-chloro-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL612189
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.12E+11 nM
|
[5] | |||
| Compound Name |
(3R,4S,5R)-2-(4-Chloro-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611880
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.31E+11 nM
|
[5] | |||
| Compound Name |
2-(4-Chloro-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329724; SCHEMBL6678245; BDBM50090844; 7-(5-Deoxy-beta-D-ribofuranosyl)-5-iodo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine; (2R,3R,4S,5R)-2-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydrofuran-3,4-diol; (2R,3R,4S,5R)-2-(4-Chloro-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.33E+11 nM
|
[6] | |||
| Compound Name |
2-(4-Amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-aminomethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322611; SCHEMBL2033304; BDBM50090862; 7-(5-Amino-5-deoxy-beta-D-ribofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine-4-amine; (2R,3R,4S,5R)-2-(4-amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-(aminomethyl)oxolane-3,4-diol
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.66E+12 nM
|
[5] | |||
| Compound Name |
2-(4-Amino-5-bromo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-aminomethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99707; BDBM50090843; 7-(5-Amino-5-deoxy-beta-D-ribofuranosyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 5.00E+12 nM
|
[6] | |||
| Compound Name |
(3R,4S,5R)-2-(4-Amino-5-bromopyrrolo[2,3-d]pyrimidin-7-yl)-5-(aminomethyl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL607751
Click to Show/Hide
|
||||
| Activity |
IC50 = 5.01E+12 nM
|
[5] | |||
| Compound Name |
(2R,3S,4R)-2-(Aminomethyl)-5-(4-chloro-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL610115
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.00E+13 nM
|
[5] | |||
| Compound Name |
2-Aminomethyl-5-(4-chloro-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330432; SCHEMBL2038994; BDBM50090867; 7-(5-Amino-5-deoxy-beta-D-ribofuranosyl)-5-iodo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine; (2R,3S,4R,5R)-2-(aminomethyl)-5-(4-chloro-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)oxolane-3,4-diol
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.00E+13 nM
|
[6] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies. J Med Chem. 2011 Mar 10;54(5):1401-20. | ||||
| REF 2 | First dual AK/GSK-3 inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents. Eur J Med Chem. 2017 Sep 29;138:438-457. | ||||
| REF 3 | Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics. J Med Chem. 2009 May 14;52(9):2880-98. | ||||
| REF 4 | Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics. J Med Chem. 2010 Jan 14;53(1):441-51. | ||||
| REF 5 | A TOPS-MODE approach to predict adenosine kinase inhibition. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3077-9. | ||||
| REF 6 | QSAR study on adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues using the hansch approach. Bioorg Med Chem Lett. 2002 Mar 25;12(6):899-902. | ||||
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