Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T89565 | Target Info | |||
| Target Name | Caspase-5 (CASP5) | ||||
| Synonyms |
Protease TY; Protease ICH-3; ICH3; ICE(rel)-III; CASP-5
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| Target Type | Patented-recorded Target | ||||
| Gene Name | CASP5 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Inhibitor 66b
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Investigative | Compound Info | ||
| Synonyms |
Thiophene Scaffold 66b; BDBM226; CHEMBL146453
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| Activity |
Ki = 63000 nM
|
[1] | |||
| Compound Name |
Inhibitor 47c
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Investigative | Compound Info | ||
| Synonyms |
Thiophene Scaffold 47c; BDBM219; CHEMBL357191
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| Activity |
Ki = 98000 nM
|
[1] | |||
| Compound Name |
(E,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-3-Carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]-2-phenylacetyl]amino]-3-methylbutanoyl]amino]-6-ethoxy-6-oxohex-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2324341; SCHEMBL15462686; BDBM50426566
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem. 2002 Nov 7;45(23):5005-22. | ||||
| REF 2 | Irreversible inhibitors of cysteine proteases. ACS Med Chem Lett. 2013 Jan 28;4(2):163-4. | ||||
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