Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T88752 | Target Info | |||
| Target Name | Ras-related C3 botulinum toxin substrate 1 (RAC1) | ||||
| Synonyms |
Cell migration-inducing gene5 protein
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| Target Type | Literature-reported Target | ||||
| Gene Name | RAC1 | ||||
| Biochemical Class | Small GTPase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
7,8-Dimethoxy-5-methylbenzo[c]phenanthridin-5-ium-2,3-diol;chloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL567815; SCHEMBL3321466
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| Activity |
IC50 = 54000 nM
|
[1] | |||
| Compound Name |
2-(4-Fluoro-3-nitrophenylamino)-N-(4-morpholinophenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL563777; ZINC7972822; BDBM50293839; AKOS034149219; MCULE-2828587870; ZU-0073945; Z30983973; 2-[(4-fluoro-3-nitrophenyl)amino]-N-[4-(morpholin-4-yl)phenyl]acetamide
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| Activity |
IC50 = 57200 nM
|
[2] | |||
| Compound Name |
Sanguinarium Chloride
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Investigative | Compound Info | ||
| Synonyms |
SANGUINARINE CHLORIDE; Viadent; Sanguinarine (chloride); Sanguinarine chloride hydrate; Sanguinarine hydrochloride; UNII-B8Z8J4400H; CHEMBL490129; 5578-73-4 (chloride); B8Z8J4400H; Pseudochelerythrine chloride;Sanguinarium chloride; MFCD00012126; Sanguinarine, chloride; Sanguinarium chloride [USAN:INN]; SANGUINARINECHLORIDE; SR-01000075650; Chelerythrine Chloride,(S); SCHEMBL43290; CTK5A4180; HY-N0052A; DTXSID30971158; HMS3263M18; Sanguinarium chloride (USAN/INN); Tox21_501108; AKOS024457036; CCG-212462; CS-4784; LP01108; KS-0000003G; NCGC00094379-01; NCGC00094379-02; NCGC00261793-01; AK546775; DB-052796; EU-0101108; FT-0603674; D05799; S 5890; Sanguinarine chloride hydrate, >=98% (HPLC); Q-100647; SR-01000075650-2; Q27274521; 13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride; 13-Methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i] phenanthridinium chloride
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| Activity |
IC50 = 58000 nM
|
[1] | |||
| Compound Name |
6,7-Dimethoxy-1-methyl-3-naphthalen-2-ylisoquinoline;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL576002
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| Activity |
IC50 = 58000 nM
|
[1] | |||
| Compound Name |
Dehydrostepholidine chloride
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Investigative | Compound Info | ||
| Synonyms |
NSC627882; CHEMBL575979; SCHEMBL3320114; CTK6J4625; NSC-627882; 2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium chloride
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| Activity |
IC50 = 63000 nM
|
[1] | |||
| Compound Name |
Tetrahydroxycanadine HCl
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL573174; SCHEMBL3316111
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| Activity |
IC50 = 68000 nM
|
[1] | |||
| Compound Name |
6-N-[2-[5-(Dimethylamino)pentan-2-ylamino]-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3237582; BDBM50007189
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| Activity |
IC50 = 95000 nM
|
[3] | |||
| Compound Name |
Chelerythrine chloride
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Investigative | Compound Info | ||
| Synonyms |
Chelerythrinechloride; Chelerythrine hydrochloride; UNII-7IC98TZ0PZ; Chelerythrine (chloride); 7IC98TZ0PZ; CHEMBL258893; 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridiniumchloride; MFCD00060717; 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride; 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride; 3895-92-9 (chloride); 34316-15-9 (cation).; C21H18ClNO4; 1,2-Dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride; Chelerythrine HCl; NSC646662; 1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride; Chelerythrine, chloride; EINECS 223-444-9; NSC 36405; SR-01000075750; Chelerythrine cloride; Chelerythrine, hydrochloride; SCHEMBL195109; KS-00001CVS; DTXSID70893481; BCPP000287; HMS3229C07; HMS3260B04; HMS3672K05; NSC36405; Tox21_500241; NSC-36405; AKOS016010038; BCP9000516; CCG-206741; CS-0205; LP00241; NSC-646662; NCGC00093703-01; NCGC00260926-01; AK115162; AS-17480; HY-12048; SC-76777; BCP0726000282; DB-049354; Chelerythrine Chloride - CAS 3895-92-9; EU-0100241; FT-0602998; V0358; Chelerythrine, hydroxide, hydrochloride (8CI); A10196; C 2932; W-5057; Q-100414; Q-200824; Q-200825; SR-01000075750-1; Q27268347; [1,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-, chloride; 1,2-DIMETHOXY-N-METHYL-[1,3]BENZODIOXOLO[5,6-C]PHE; 1,2-dimethoxy-n-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(6,7-Dimethoxy-1-methylisoquinolin-3-yl)benzene-1,2-diol hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL574677; SCHEMBL3318735
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| Activity |
IC50 = 104000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5594-8 | ||||
| REF 2 | Virtual screening approach for the identification of new Rac1 inhibitors. J Med Chem. 2009 Jul 23;52(14):4087-90. | ||||
| REF 3 | 2-Amino-3-(phenylsulfanyl)norbornane-2-carboxylate: an appealing scaffold for the design of Rac1-Tiam1 protein-protein interaction inhibitors. J Med Chem. 2014 Apr 10;57(7):2953-62. | ||||
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