Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T88699 | Target Info | |||
Target Name | Polyamine oxidase (PAOX) | ||||
Synonyms |
Peroxisomal N(1)acetylspermine/spermidine oxidase; PAOX
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Target Type | Literature-reported Target | ||||
Gene Name | PAOX | ||||
Biochemical Class | CH-NH donor oxidoreductase | ||||
UniProt ID |
Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
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Compound Name |
N-(8-Aminooctyl)acetamide
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Investigative | Compound Info | ||
Synonyms |
N-(8-Amino-octyl)-acetamide; Acetamide, N-(8-aminooctyl)-; CHEMBL174669; ACMC-20mj77; SCHEMBL1409025; CTK0C8486; DTXSID30403106; ZINC3130416; BDBM50405928; AKOS024331252; MCULE-6145399847
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Activity |
Ki = 75000 nM
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[1] | |||
Compound Name |
N-(10-Aminodecyl)acetamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL177890; SCHEMBL1409041; N-(10-Amino-decyl)-acetamide; ZINC3130432; BDBM50405940; AKOS024331305; MCULE-4045372511
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Activity |
Ki = 110000 nM
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[1] | |||
Compound Name |
N-(6-Aminohexyl)-2-chloroacetamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL174887; SCHEMBL18379858; BDBM50405930
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Activity |
Ki = 130000 nM
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[1] |
Non Binders of This Target (in total, 8 non binders) | Download | Top | |||
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Compound Name |
Methyl N-(8-aminooctyl)carbamate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL176764; BDBM50405934
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Activity |
Ki = 260000 nM
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[1] | |||
Compound Name |
N-Methyl-N''-prop-2-ynyl-butane-1,4-diamine
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Investigative | Compound Info | ||
Synonyms |
CHEMBL59623; BDBM50026230
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Activity |
Ki = 310000 nM
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[2] | |||
Compound Name |
N-(6-Aminohexyl)methanesulfonamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL436093; SCHEMBL14865837; BDBM50405929
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Activity |
Ki = 376000 nM
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[1] | |||
Compound Name |
N*1*-Prop-2-ynyl-butane-1,4-diamine
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Investigative | Compound Info | ||
Synonyms |
CHEMBL292770; BDBM50026233; AKOS013268932
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Activity |
Ki = 425000 nM
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[2] | |||
Compound Name |
N-(8-Aminooctyl)methanesulfonamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL177777; BDBM50405941
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Activity |
Ki = 650000 nM
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[1] | |||
Compound Name |
N-Acetylputrescine
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Investigative | Compound Info | ||
Synonyms |
N-(4-aminobutyl)acetamide; Acetylputrescine; Acetamide, N-(4-aminobutyl)-; CHEMBL81241; monoacetylputrescine; N-acetylputrescinehydrochloride; 4-acetylaminobutylamine; Putrescine, N-acetyl-; ACMC-1AQE1; N-Acetyl-1,4-butanediamine; (4-(Acetylamino)butyl)amine; SCHEMBL361286; CTK1H2141; DTXSID80205596; ZINC1529505; ANW-32616; BDBM50405938; MFCD10024834; AKOS005215796; MCULE-8971714473; NS-01048; DB-031177; C02714; Q27102595; 36864054-D6F8-4927-901B-91A60738B493
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Activity |
Ki = 800000 nM
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[1] | |||
Compound Name |
N(1)-Acetylspermidine
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Investigative | Compound Info | ||
Synonyms |
N1-Acetylspermidine; 1-N-Acetylspermidine; N-Acetylspermidine; N-(3-((4-Aminobutyl)amino)propyl)acetamide; N-[3-(4-aminobutylamino)propyl]acetamide; N-{3-[(4-aminobutyl)amino]propyl}acetamide; CHEMBL176800; Acetamide, N-[3-[(4-aminobutyl)amino]propyl]-; an N-acetylspermidine; Acetamide, N-(3-((4-aminobutyl)amino)propyl)-; n-(3-((4-aminobutyl)amino)propyl)-acetamide; SCHEMBL183048; DTXSID80162175; ZINC1532698; BDBM50405933; AKOS024183045; C00612; Q3869337; ACETAMIDE,N-(3-((4-AMINOBUTYL)AMINO)PROPYL)-; n-{3-[(4-aminobutyl)amino]propyl}acetamide hydrochloride
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Activity |
Ki = 1370000 nM
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[1] | |||
Compound Name |
N-Butyrylputrescine
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Investigative | Compound Info | ||
Synonyms |
CHEMBL177217; SCHEMBL18794739; BDBM50405936
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Activity |
Ki = 29000000 nM
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[1] | |||
Click to Show/Hide the Information of All Non Binders |
References | Top | ||||
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REF 1 | Design and synthesis of inhibitors of N8-acetylspermidine deacetylase. J Med Chem. 1989 May;32(5):984-9. | ||||
REF 2 | N-2,3-Butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase. J Med Chem. 1985 Jan;28(1):1-2. |
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