Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T88505 | Target Info | |||
| Target Name | Nuclear factor erythroid 2-related factor 2 (Nrf2) | ||||
| Synonyms |
Nuclear factor, erythroid derived 2, like 2; NRF2; NFE2-related factor 2; NF-E2-related factor 2; HEBP1
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| Target Type | Successful Target | ||||
| Gene Name | NFE2L2 | ||||
| Biochemical Class | Basic leucine zipper bZIP | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 41 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-tert-butylbenzene-1,4-diol
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Investigative | Compound Info | ||
| Synonyms |
Tert-Butylhydroquinone; tert-Butylhydroquinone; 1948-33-0; TBHQ; 2-tert-Butylhydroquinone; T-BUTYLHYDROQUINONE; MTBHQ; t-Butyl hydroquinone; 2-tert-Butyl-1,4-benzenediol; 2-t-Butylhydroquinone; Mono-tert-butylhydroquinone; Sustane; Tenox TBHQ; tert-Butyl-1,4-benzenediol; Mono-tertiarybutylhydroquinone; Hydroquinone, tert-butyl-; Banox 20BA; 1,4-Benzenediol, 2-(1,1-dimethylethyl)-; tertiary-Butylhydroquinone; 2-(1,1-Dimethylethyl)-1,4-benzenediol; 2-tert-Butyl(1,4)hydroquinone; 2-(tert-butyl)benzene-1,4-diol
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| Activity |
EC50 = 91530 nM
|
[1] | |||
| Compound Name |
(3Z)-8-Methoxy-3-phenacylidene-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431289; BDBM50493509
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| Activity |
EC50 = 58540 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(3,5-Difluorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431296; BDBM50493500
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| Activity |
EC50 = 58860 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(3-Bromophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431297; BDBM50493505
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|
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| Activity |
EC50 = 59120 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(2-Fluorophenyl)-2-oxoethylidene]-9,10-dimethoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431229; BDBM50493499
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| Activity |
EC50 = 75850 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(4-Fluorophenyl)-2-oxoethylidene]-9,10-dimethoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431288; BDBM50493496
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|
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| Activity |
EC50 = 81540 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(4-Fluorophenyl)-2-oxoethylidene]-10-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431313; BDBM50493510
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| Activity |
EC50 = 87950 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(3-Fluorophenyl)-2-oxoethylidene]-9,10-dimethoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431287; BDBM50493497
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|
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| Activity |
EC50 = 92000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(3,4-Dimethoxyphenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431303; BDBM50493486
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|
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| Activity |
EC50 = 93020 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(4-Fluorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431321; BDBM50493504
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(4-Methylphenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431301; BDBM50493503
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(3-Fluorophenyl)-2-oxoethylidene]-9-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431293; BDBM50493493
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[2-(3-Fluorophenyl)-2-oxoethylidene]-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinoline-4(11bH)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431305; BDBM50493512
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-Oxo-2-(4-phenylphenyl)ethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431302; BDBM50493487
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-9,10-Dimethoxy-3-phenacylidene-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431314; BDBM50493501
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(3-Chlorophenyl)-2-oxoethylidene]-9,10-dimethoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431228; BDBM50493481
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(3-Methoxyphenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431323; BDBM50493489
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(2-Fluorophenyl)-2-oxoethylidene]-8-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431291; BDBM50493495
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-9,10-Dimethoxy-3-[2-(3-methoxyphenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431286; BDBM50493517
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(2-Methoxyphenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431306; BDBM50493484
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(3-Chlorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431317; BDBM50493514
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(2,4-Dichlorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431299; BDBM50493507
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-10-Methoxy-3-[2-(3-nitrophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431310; BDBM50493506
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-9-Methoxy-3-phenacylidene-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431292; BDBM50493494
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(2-Nitrophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431304; BDBM50493485
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(3,4-Difluorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431298; BDBM50493488
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(3-Chlorophenyl)-2-oxoethylidene]-10-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431308; BDBM50493502
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(3-Fluorophenyl)-2-oxoethylidene]-10-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431312; BDBM50493482
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-10-Methoxy-3-phenacylidene-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431307; BDBM50493480
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(2-Fluorophenyl)-2-oxoethylidene]-9-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431294; BDBM50493508
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-10-Methoxy-3-[2-(3-methoxyphenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431311; BDBM50493483
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(4-Chlorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431318; BDBM50493491
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(2-Chlorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431316; BDBM50493492
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(4-Nitrophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431320; BDBM50493490
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(3-Nitrophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431300; BDBM50493513
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(3-Fluorophenyl)-2-oxoethylidene]-8-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431290; BDBM50493516
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(2-Fluorophenyl)-2-oxoethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431322; BDBM50493519
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-Oxo-2-[3-(trifluoromethyl)phenyl]ethylidene]-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431295; BDBM50493515
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[2-(2-Fluorophenyl)-2-oxoethylidene]-10-methoxy-2,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431309; BDBM50493511
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
CID 5788151
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431319; CHEMBL3191088; HMS2389E17; BDBM50493518
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(2-Oxo-2-phenylethylidene)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431315; MLS000325199; CHEMBL3195205; HMS2389E21; BDBM50493520; SMR000163382
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice. J Med Chem. 2013 Oct 24;56(20):7925-38. | ||||
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