Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T87831 | Target Info | |||
| Target Name | N-formyl peptide receptor (FPR1) | ||||
| Synonyms |
N-formylpeptide chemoattractant receptor; FPR1; FPR
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| Target Type | Clinical trial Target | ||||
| Gene Name | FPR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 26 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(1,3-Benzodioxol-5-yl)-2-[5-[(3-methoxyphenyl)methyl]-6-oxo-3-thiophen-2-ylpyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391262; BDBM50435930
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Iodophenyl)-2-(3-methyl-6-oxopyridazin-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391445; SCHEMBL18015910; BDBM50435898
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[3-Benzyl-5-[(4-methoxyphenyl)methyl]-6-oxopyridazin-1-yl]-N-(4-bromophenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391276; BDBM50435916
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Bromophenyl)-2-[3-(4-methoxyphenyl)-5-[(4-methoxyphenyl)methyl]-6-oxopyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391264; BDBM50435928
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-Bromo-N-[2-[2-(4-bromoanilino)-2-oxoethyl]-6-methyl-3-oxopyridazin-4-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391451; BDBM50435892
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Bromophenyl)-2-[5-[(3,5-dimethoxyphenyl)methyl]-3-methyl-6-oxopyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391283; SCHEMBL18015771; BDBM50435909
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-yl)-2-[5-[(3-methoxyphenyl)methyl]-3-(4-methylphenyl)-6-oxopyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391271; BDBM50435921
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Fluorophenyl)-2-[5-[(3-methoxyphenyl)methyl]-6-oxo-3-thiophen-2-ylpyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391263; BDBM50435929
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Fluorophenyl)-2-[3-(4-methoxyphenyl)-5-[(3-methoxyphenyl)methyl]-6-oxopyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391266; BDBM50435926
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Bromophenyl)-2-[3-(4-fluorophenyl)-5-[(4-methoxyphenyl)methyl]-6-oxopyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391273; SCHEMBL18015791; BDBM50435919
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Fluorophenyl)-2-[3-(4-fluorophenyl)-5-[(3-methoxyphenyl)methyl]-6-oxopyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391275; SCHEMBL18015766; BDBM50435917
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Bromophenyl)-2-[5-[(3-bromophenyl)methyl]-3-methyl-6-oxopyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391282; SCHEMBL18015760; BDBM50435910
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Fluorophenyl)-2-[5-[(3-methoxyphenyl)methyl]-3-(4-methylphenyl)-6-oxopyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391272; SCHEMBL18015783; BDBM50435920
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Bromophenyl)-2-[3-methyl-6-oxo-5-[[4-(trifluoromethyl)phenyl]methyl]pyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391284; SCHEMBL18015772; BDBM50435908
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Bromophenyl)-2-[5-[(4-cyanophenyl)methyl]-3-methyl-6-oxopyridazin-1-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391441; SCHEMBL18015871; BDBM50435902
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-yl)-2-[3-(4-methoxyphenyl)-5-[(3-methoxyphenyl)methyl]-6-oxopyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391265; BDBM50435927
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-yl)-2-[5-[(3-methoxyphenyl)methyl]-6-oxo-3-phenylpyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391259; BDBM50435933
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-yl)-2-[3-(4-fluorophenyl)-5-[(3-methoxyphenyl)methyl]-6-oxopyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391274; BDBM50435918
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[3-(4-Chlorophenyl)-5-[(3-methoxyphenyl)methyl]-6-oxopyridazin-1-yl]-N-(4-fluorophenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391269; BDBM50435923
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(5-Benzyl-3-methyl-6-oxopyridazin-1-yl)-N-(4-fluorophenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391278; SCHEMBL18015752; BDBM50435914
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-yl)-2-[3-(4-chlorophenyl)-5-[(3-methoxyphenyl)methyl]-6-oxopyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391268; BDBM50435924
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Bromophenyl)-2-[5-[(4-methoxyphenyl)methyl]-6-oxo-3-thiophen-2-ylpyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391261; BDBM50435931
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Bromophenyl)-2-[3-(4-chlorophenyl)-5-[(4-methoxyphenyl)methyl]-6-oxopyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391267; BDBM50435925
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Iodophenyl)-2-(3-methyl-6-oxo-4,5-dihydropyridazin-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391444; SCHEMBL18015911; BDBM50435899
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Bromophenyl)-2-[5-[(4-methoxyphenyl)methyl]-3-(4-methylphenyl)-6-oxopyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391270; SCHEMBL18015759; BDBM50435922
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Fluorophenyl)-2-[5-[(3-methoxyphenyl)methyl]-6-oxo-3-phenylpyridazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391260; BDBM50435932
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists. Eur J Med Chem. 2013 Jun;64:512-28. | ||||
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