Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86646 | Target Info | |||
| Target Name | HUMAN beta adrenergic receptor (BAR) | ||||
| Synonyms |
Beta adrenoreceptor
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| Gene Name | ADRB1; ADRB2; ADRB3 | ||||
| Biochemical Class | G-protein coupled receptor 1 family | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[2-[[2-Hydroxy-3-(4-methoxyphenoxy)propyl]amino]ethyl]-4-imidazol-1-ylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99188; SCHEMBL8781217; BDBM50228534; 4-(1H-Imidazol-1-yl)-N-[2-[2-hydroxy-3-(4-methoxyphenoxy)propylamino]ethyl]benzamide; N-[2-[[2-Hydroxy-3-(4-methoxyphenoxy)propyl]amino]ethyl]-4-(1H-imidazol-1-yl)benzamide
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| Activity |
IC50 = 61400 nM
|
[1] | |||
| Compound Name |
1-[4-[4-(Methylsulfonylamino)phenyl]-1-piperazinyl]-3-[4-(2-methoxyethyl)phenoxy]-2-propanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99391; SCHEMBL8781255; BDBM50228538; N-[4-[4-[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]piperazin-1-yl]phenyl]methanesulfonamide
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| Activity |
IC50 = 109000 nM
|
[1] | |||
| Compound Name |
4-Methylsulfonylamino-N-[2-[2-hydroxy-3-phenoxypropylamino]cyclohexyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99179; BDBM50228545
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| Activity |
IC50 = 192000 nM
|
[1] | |||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[2-[[2-Hydroxy-3-[4-(methanesulfonamido)phenoxy]propyl]amino]ethyl]-4-imidazol-1-ylbenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99814; SCHEMBL10474945; BDBM50228548; 4-(1H-Imidazol-1-yl)-N-[2-[2-hydroxy-3-[4-(methylsulfonylamino)phenoxy]propylamino]ethyl]benzamide
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| Activity |
IC50 = 227000 nM
|
[1] | |||
| Compound Name |
1-[4-[4-(Methylsulfonylamino)phenyl]-1-piperazinyl]-3-(4-acetylaminophenoxy)-2-propanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL95795; BDBM50228554
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| Activity |
IC50 = 293000 nM
|
[1] | |||
| Compound Name |
1-[4-(Methylsulfonylamino)benzoyl]-4-[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]piperazine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL95985; SCHEMBL9839016; BDBM50228555
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| Activity |
IC50 = 360000 nM
|
[1] | |||
| Compound Name |
N-[4-[1-Hydroxy-2-(3-methylimidazol-3-ium-1-yl)ethyl]phenyl]methanesulfonamide;chloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL78234; SCHEMBL9661488; BDBM50226751
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| Activity |
IC50 = 2350000 nM
|
[2] | |||
| Compound Name |
Sematilide
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Investigative | Compound Info | ||
| Synonyms |
UNII-0NHB13IN3R; 0NHB13IN3R; N-(2-(Diethylamino)ethyl)-4-(methylsulfonamido)benzamide; Sematilide [INN]; CHEMBL95804; SCHEMBL161098; DTXSID0058720; BCP26212; ZINC4194761; BDBM50228547; SDCCGSBI-0633733.P001; NCGC00186049-02; DB-058612; HY-101436; CS-0021329; FT-0760802; Q7449133; 3H-1,2,4-Triazole-3-thione,5-ethyl-1,2-dihydro-(9CI); N-[2-(diethylamino)ethyl]-4-(methanesulfonamido)benzamide; RU-752;RU 752;RU752; CK-1752; CK1752; CK 1752
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| Activity |
IC50 = 7000000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity. J Med Chem. 1990 Oct;33(10):2883-91. | ||||
| REF 2 | Synthesis and antiarrhythmic activity of novel 3-alkyl-1-[omega-[4-[(alkylsulfonyl)amino]phenyl]-omega- hydroxyalkyl]-1H-imidazolium salts and related compounds. J Med Chem. 1987 Apr;30(4):696-704. | ||||
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