Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86552 | Target Info | |||
| Target Name | Tumor necrosis factor receptor type I (TNF-R1) | ||||
| Synonyms |
p60; p55; Tumor necrosis factor-binding protein 1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNFR1; TNFR-I; TNFAR; TNF-RI; TBPI; CD120a
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| Target Type | Clinical trial Target | ||||
| Gene Name | TNFRSF1A | ||||
| Biochemical Class | Cytokine receptor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-(3,5-Di-tert-butyl-4-hydroxyphenyl)-3-(4-methoxyphenyl)-2-propene-1-one
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Investigative | Compound Info | ||
| Synonyms |
NSC635191; CHEMBL38067; SCHEMBL22198100; ZINC5187261; BDBM50141504; NSC-635191; 1-(3,5-Di-tert-butyl-4-hydroxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one; (E)-1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-(4-methoxy-phenyl)-propenone; (E)-1-(3,5-ditert-butyl-4-hydroxy-phenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-(5-Bromo-2,4-dimethoxy-phenyl)-1-(3,4,5-trimethoxy-phenyl)-propan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL39857; BDBM50141483
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(4-{2-Methoxy-4-[(E)-3-(2-methoxy-5-thiophen-2-yl-phenyl)-acryloyl]-phenoxymethyl}-phenyl)-carbamic acid tert-butyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL288726; BDBM50141533
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(E)-3-(3-Bromo-4,5-dimethoxyphenyl)-1-(3,5-dimethoxy-4-phenylmethoxyphenyl)prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL33952; BDBM50141545; (E)-1-(4-Benzyloxy-3,5-dimethoxy-phenyl)-3-(3-bromo-4,5-dimethoxy-phenyl)-propenone
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(E)-3-[5-(1-Benzothiophen-2-yl)-2,4-dimethoxyphenyl]-1-[4-(cyclopropylmethoxy)-3,5-dimethoxyphenyl]prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL36000; BDBM50141537
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-(5-Bromo-2-methoxy-phenyl)-1-(3,4,5-trimethoxy-phenyl)-propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL37197; BDBM50141489
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-alpha-induced VCAM-1 expression. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1513-7. | ||||
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