Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86399 | Target Info | |||
| Target Name | Bromodomain-containing protein 2 (BRD2) | ||||
| Synonyms |
Really interesting new gene 3 protein; RING3; O27.1.1; KIAA9001
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| Target Type | Clinical trial Target | ||||
| Gene Name | BRD2 | ||||
| Biochemical Class | Bromodomain | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 15 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[(E)-2-(2,4-Dimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-enoyl]-1,3-dihydroquinoxalin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589481; BDBM50094890
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
7-Methoxy-4-[(E)-3-(4-methoxyphenyl)-2-phenylprop-2-enoyl]-1,3-dihydroquinoxalin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589477; BDBM50094912
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[(E)-2-(3,4-Dimethylphenyl)-3-(4-methoxyphenyl)prop-2-enoyl]-1,3-dihydroquinoxalin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589472; BDBM50094900
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(cis)-1-Acetyl-2-methyl-6-[4-(1-piperidinylmethyl)phenyl]-1,2,3,4-tetrahydro-4-quinolinamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353994; SCHEMBL1874283; BDBM50028104; (2S,4R)-1-acetyl-2-methyl-6-[4-(1-piperidinylmethyl)phenyl]-1,2,3,4-tetrahydro-4-quinolinamine
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| Activity |
IC50 = 50118.72 nM
|
[2] | |||
| Compound Name |
4-{4-[(Dimethylamino)methyl]-3,5-dimethoxyphenyl}-2-methyl-1,2-dihydroisoquinolin-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3824146; BI-7271; SCHEMBL19869875; BDBM50183561; J3.533.935C
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| Activity |
IC50 = 50857 nM
|
[3] | |||
| Compound Name |
3-Butyl-8-[(6-Butyl-5,7-Dimethyl-[1,2,4]triazolo[1,5-A]pyrimidin-2-Yl)sulfanylmethyl]-7-Ethyl-Purine-2,6-Dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3774931; SCHEMBL19066319; BDBM50150069; ZINC68716836; AKOS008738479; MCULE-3915679099; J3.601.437G; Q27455888; Z642854042
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| Activity |
IC50 = 59000 nM
|
[4] | |||
| Compound Name |
5-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-1,3,6-trimethylpyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3824351; SCHEMBL19869785; BDBM50183452
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| Activity |
IC50 = 59555 nM
|
[3] | |||
| Compound Name |
8-[4-[(Dimethylamino)methyl]-3,5-dimethoxyphenyl]-6-methylpyrido[4,3-d]pyrimidin-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3824312; SCHEMBL19869879; BDBM50183453
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[4-[(Dimethylamino)methyl]-3,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One
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Investigative | Compound Info | ||
| Synonyms |
BI-7273; CHEMBL3823478; BI7273; GTPL9146; SCHEMBL19869878; EX-A990; BCP17545; BDBM50183448; MFCD30489736; s8179; ZINC575448880; CCG-268068; CS-5887; HY-100351; J3.533.936A; A16068; Q27075221
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Ethyl N-[(4S)-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2430872; BDBM50441169
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| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
4-[4-[(Dimethylamino)methyl]-2,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One
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Investigative | Compound Info | ||
| Synonyms |
BI-9564; BI 9564; CHEMBL3823101; GTPL8950; SCHEMBL19869872; BCP17135; EX-A1652; BDBM50183449; BI9564; s8113; AKOS027470219; ZINC526061652; CCG-268067; CS-5888; AK685542; BP-25349; BS-15735; DS-001715; HY-100352; BI-9564, >=97% (HPLC); J3.600.898I; Q27075224
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(4-Hydroxy-3,5-Dimethylphenyl)-7-Methyl-5,6,7,8-Tetrahydropyrido[4',3':4,5]thieno[2,3-D]pyrimidin-4(3h)-One
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Investigative | Compound Info | ||
| Synonyms |
FL-411; CHEMBL4077274; BRD4-IN-1; FL411; SCHEMBL22374551; EX-A3383; BDBM50251045; FL 411; s1027; FL-411,; BS-16486; HY-111102; AK00779493; CS-0034229
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
5-[4-[(Dimethylamino)methyl]-3,5-dimethoxyphenyl]-7-methyl-1,7-naphthyridin-8-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3822909; SCHEMBL19857609; BDBM50183560
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[4-[(Dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,6-naphthyridin-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823859; SCHEMBL19869894; BDBM50183517
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
8-[4-[(Dimethylamino)methyl]-3,5-dimethoxyphenyl]-6-methyl-1,6-naphthyridin-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3822539; SCHEMBL19869895; BDBM50183454
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2818-23. | ||||
| REF 2 | The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor. J Med Chem. 2014 Oct 9;57(19):8111-31. | ||||
| REF 3 | Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J Med Chem. 2016 May 26;59(10):4462-75. | ||||
| REF 4 | Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins. J Med Chem. 2016 Feb 25;59(4):1634-41. | ||||
| REF 5 | Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains. J Med Chem. 2013 Oct 10;56(19):7501-15. | ||||
| REF 6 | Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer. J Med Chem. 2017 Dec 28;60(24):9990-10012. | ||||
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