Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86161 | Target Info | |||
| Target Name | Prolyl endopeptidase (PREP) | ||||
| Synonyms |
Post-proline cleaving enzyme; PREP; PE
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| Target Type | Clinical trial Target | ||||
| Gene Name | PREP | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 153 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Vildagliptin
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|
Approved | Compound Info | ||
| Synonyms |
Equa; Galvu; Galvus; Jalra; Xiliarx; Galvus (TN); Vidagliptin (see Vildagliptin); Vildagliptin (JAN/USAN/INN); (2S)-(((3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile; (2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile; 1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile; 2-Pyrrolidinecarbonitrile, 1-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-, (2S)-(9CI)
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Linagliptin
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Approved | Compound Info | ||
| Synonyms |
Ondero; BI 1356; BI-1356; Ondero (TN); BI-1356-BS; (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Alogliptin
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Approved | Compound Info | ||
| Synonyms |
850649-61-5; UNII-JHC049LO86; alogliptina; 2-({6-[(3r)-3-Aminopiperidin-1-Yl]-3-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl}methyl)benzonitrile; SYR-322; JHC049LO86; (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile; CHEBI:72323; AK322010; 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile; vipidia; Alogliptin [INN]; Alogliptin (SYR-322); alogliptinum; alogliptine; HSDB 8203; UNII-JHC049LO86
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Sitagliptin
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Approved | Compound Info | ||
| Synonyms |
486460-32-6; Januvia; Xelevia; Sitagliptan; MK-0431; UNII-QFP0P1DV7Z; Tesavel; QFP0P1DV7Z; (3R)-3-AMINO-1-[3-(TRIFLUOROMETHYL)-5H,6H,7H,8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7-YL]-4-(2,4,5-TRIFLUOROPHENYL)BUTAN-1-ONE; (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE; CHEBI:40237; (R)-3-AMINO-1-(3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL)-4-(2,4,5-TRIFLUOROPHENYL)BUTAN-1-ONE; Janumet; Sitagliptin phosphate; Januvia (TN); Sitagliptin (PropINN); Januvia (merck & Co); (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; (3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; Sitagliptin/atovastatin
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Berberine
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Phase 4 | Compound Info | ||
| Synonyms |
berberine; 2086-83-1; Berberin; Umbellatine; UNII-0I8Y3P32UF; 0I8Y3P32UF; CHEBI:16118; EINECS 218-229-1; Berberal; BRN 3570374; ST055798; 9,10-Dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetrahydroberbinium; Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-; 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium; Berbamine sulphate acid; CHEMBL12089; 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium; BERBINIUM, 7,8,13,13a-TETRAHYDRO-9,10-DIMETHOXY-2,3-(METHYLE
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| Activity |
IC50 = 145000 nM
|
[2] | |||
| Compound Name |
MK-3102
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Phase 3 | Compound Info | ||
| Synonyms |
Omarigliptin
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|
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| Activity |
IC50 ~ 67000 nM
|
[3] | |||
| Compound Name |
4-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-4-oxobutanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022520; BDBM50382273
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]-4-oxobutanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022519; BDBM50382272
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
CID 44123747
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819090; SCHEMBL162310; BDBM50351402
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1,2,4,5-Tetrakis(phenylmethoxymethyl)-3,6-bis(4-phenylmethoxyphenyl)benzene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314369; BDBM50046272
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(2S)-1-[2-[2-Methoxyethyl(quinolin-4-ylmethyl)amino]acetyl]pyrrolidine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233547; BDBM50009322
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
[4-Acetyloxy-2,5-bis[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-3,6-bis(methoxymethyl)phenyl] acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314371; BDBM50046274
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Tert-butyl-[4-[4-[4-[tert-butyl(dimethyl)silyl]oxyphenyl]-2,3,5,6-tetrakis(methoxymethyl)phenyl]phenoxy]-dimethylsilane
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314368; BDBM50046263
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
N-[3-[(3-Acetamidophenoxy)-[1-(pyrrolidine-2-carbonyl)pyrrolidin-2-yl]phosphoryl]oxyphenyl]acetamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL9263
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| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
5-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385300; SCHEMBL15130006; BDBM50434169
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
(2S)-1-(2-Naphthalen-2-yloxyacetyl)pyrrolidine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385288; BDBM50434181
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|
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
N'-[Bis(4-fluorophenyl)methyl]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]butanediamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022518; BDBM50382271
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-[4-(3,4-difluorophenyl)triazol-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022521; BDBM50382274
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N'-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-N-[(4-fluorophenyl)methyl]butanediamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022517; BDBM50382270
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(2-Oxo-2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233846; BDBM50009368
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|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-hydroxy-2-methylquinoline-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385294; SCHEMBL15138746; BDBM50434175
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|
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| Activity |
IC50 = 53600 nM
|
[9] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL567278; SCHEMBL8272737; BDBM50302955
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|
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| Activity |
IC50 = 57000 nM
|
[11] | |||
| Compound Name |
Methyl 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL449310; BDBM50259883; 3alpha-Acetoxy-27-hydroxylupa-20(29)-ene-24-oic acid methyl ester
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| Activity |
IC50 = 57430 nM
|
[12] | |||
| Compound Name |
N-[(1R,3S)-3-[(1S)-1-Amino-2-oxo-2-pyrrolidin-1-ylethyl]cyclopentyl]naphthalene-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL169812; BDBM50141638
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| Activity |
IC50 = 59000 nM
|
[13] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(3-(1-(trifluoromethyl)cyclopropyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL565813; SCHEMBL8274504; BDBM50302958
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| Activity |
IC50 = 61000 nM
|
[11] | |||
| Compound Name |
[(2R)-1-[(2R)-2-Amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL305170; SCHEMBL14160935; BDBM50050517; AKOS015909815; ZINC169987523
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| Activity |
IC50 = 61000 nM
|
[14] | |||
| Compound Name |
(2S)-1-[(3Ar,4S,5R,7aS)-2-benzyl-5-methyl-3-oxo-3a,4,5,7a-tetrahydro-1H-isoindole-4-carbonyl]pyrrolidine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818446; BDBM50180680
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| Activity |
Ki = 62000 nM
|
[15] | |||
| Compound Name |
Ethyl 4-((1S,5R,6s)-6-(2-((2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl)-2-oxoethylamino)-3-aza-bicyclo[3.1.0]hexan-3-yl)benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL480154; BDBM50251720
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| Activity |
IC50 = 62200 nM
|
[16] | |||
| Compound Name |
Benzyl N-[(3aS,4R,5S,7aR)-4-[(2S)-2-cyanopyrrolidine-1-carbonyl]-5-methyl-3-oxo-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818472; BDBM50180666
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|
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| Activity |
Ki = 62500 nM
|
[15] | |||
| Compound Name |
(R)-1-((S)-2-(3-(1-Acetylazetidin-3-yl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL567279; SCHEMBL8272713; BDBM50302962
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| Activity |
IC50 = 65000 nM
|
[11] | |||
| Compound Name |
Ethyl 4-(4-chlorophenyl)-5-methyl-2,3-dihydrofuro[3,2-c]quinolin-5-ium-8-carboxylate;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1087094
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| Activity |
IC50 = 65000 nM
|
[2] | |||
| Compound Name |
N-[(3As,4R,7aR)-3-oxo-4-(pyrrolidine-1-carbonyl)-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]-2-phenylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3819072; BDBM50180671
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| Activity |
Ki = 65000 nM
|
[15] | |||
| Compound Name |
Benzyl N-[(3aS,4R,5S,7aR)-5-methyl-3-oxo-4-(pyrrolidine-1-carbonyl)-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818541; BDBM50180672
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| Activity |
Ki = 67000 nM
|
[15] | |||
| Compound Name |
(2S)-1-[2-[[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-methylamino]acetyl]pyrrolidine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233549; BDBM50009325
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| Activity |
IC50 = 67000 nM
|
[7] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(5-(1-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL585290; SCHEMBL8272718; BDBM50302970
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| Activity |
IC50 = 72000 nM
|
[11] | |||
| Compound Name |
US9346814, Ref Cmpd No 10
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3934376; BDBM233329
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| Activity |
IC50 = 74100 nM
|
[9] | |||
| Compound Name |
Ethyl 5-methyl-4-naphthalen-1-yl-2,3-dihydrofuro[3,2-c]quinolin-5-ium-8-carboxylate;iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3219657
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| Activity |
IC50 = 75000 nM
|
[17] | |||
| Compound Name |
(4-Methoxy-phenyl)-carbamic acid (1R,3S)-3-((S)-1-amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclohexyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL171033; BDBM50141622
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| Activity |
IC50 = 76000 nM
|
[13] | |||
| Compound Name |
N-[(1S,3S)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-4-trifluoromethanesulfonyl-benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL168281; BDBM50141627
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| Activity |
IC50 = 77000 nM
|
[13] | |||
| Compound Name |
2-Indan-2-yl-1-[(S)-2-(pyrrolidine-1-carbonyl)-pyrrolidin-1-yl]-ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL65463; SCHEMBL7303475; BDBM50038872; (2S)-1-[2-[(2,3-Dihydro-1H-inden)-2-yl]acetyl]-2-[(pyrrolidin-1-yl)carbonyl]pyrrolidine; (S)-2-(2,3-dihydro-1H-inden-2-yl)-1-(2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl)ethanone
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| Activity |
IC50 = 80000 nM
|
[18] | |||
| Compound Name |
Benzyl N-[(3aR,4S,7aS)-4-[(2S)-2-cyanopyrrolidine-1-carbonyl]-3-oxo-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818999; BDBM50180677
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| Activity |
Ki = 80000 nM
|
[15] | |||
| Compound Name |
(S)-N-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385281; SCHEMBL15138980; BDBM50434188; (S)-N-(2-(2-cyanopyrrolidine-1-yl)-2-oxoethyl)quinoline-4-carboxamide; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
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| Activity |
IC50 = 83500 nM
|
[9] | |||
| Compound Name |
1-((S)-2-(Pyrrolidine-1-carbonyl)pyrrolidin-1-yl)-2-((R)-1,2,3,4-tetrahydronaphthalen-2-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL65561; SCHEMBL7297437; BDBM50038875; 1-{1-[(R)-(+)-1,2,3,4-tetrahydronapthalen-2-ylacetyl]-L-prolyl}pyrrolidine; (2S)-1-[2-[[(R)-1,2,3,4-Tetrahydronaphthalen]-2-yl]acetyl]-2-[(pyrrolidin-1-yl)carbonyl]pyrrolidine
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| Activity |
IC50 = 91000 nM
|
[18] | |||
| Compound Name |
[(2R)-1-[(2R)-2-(Pyridine-3-carbonylamino)propanoyl]pyrrolidin-2-yl]boronic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333028; BDBM50431240
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| Activity |
IC50 = 91000 nM
|
[19] | |||
| Compound Name |
1-((S)-2-(Pyrrolidine-1-carbonyl)pyrrolidin-1-yl)-2-((S)-1,2,3,4-tetrahydronaphthalen-2-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL302398; SCHEMBL7303569; BDBM50038882; 1-{1-[(S)-(-)-1,2,3,4-tetrahydronaphthalen-2-ylacetyl]-L-prolyl}pyrrolidine; (2S)-1-[2-[[(S)-1,2,3,4-Tetrahydronaphthalen]-2-yl]acetyl]-2-[(pyrrolidin-1-yl)carbonyl]pyrrolidine
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| Activity |
IC50 = 94000 nM
|
[18] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(3-(3,5-difluoropyridin-2-yl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL566829; SCHEMBL14282762; BDBM50302966
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-[(5-Cyanopyridin-2-yl)amino]-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385290; BDBM50434179
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(4-Methoxy-phenyl)-carbamic acid (1S,3S)-3-((S)-1-amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL355716; BDBM50141635
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[2-[(2S,4R)-2-Cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233841; BDBM50009365
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[2-[(2S,4S)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022526; BDBM50382279
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(4-fluorophenyl)-1H-imidazo[4,5-b]pyridine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233573; BDBM50009354
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2S)-1-(2-Benzamidoacetyl)-N-tert-butylpyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022524; BDBM50382277
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-[2-[(2S)-2-Cyano-4-ethylpyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022532; BDBM50382285
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-Benzyl-7-but-2-ynyl-3-methyl-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616904
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL567728; SCHEMBL4957007; BDBM50302971
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(4-Methoxy-phenyl)-carbamic acid (1R,3S)-3-((S)-1-amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL355203; BDBM50141637
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
4-N-[(1R,3R)-3-[(1S)-1-Amino-2-oxo-2-pyrrolidin-1-ylethyl]cyclopentyl]benzene-1,4-disulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL169179; BDBM50141621
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
1-[(4-Methoxyquinazolin-2-yl)methyl]-3-methyl-7-(3-methylbut-2-enyl)-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616918
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(S)-2-Amino-2-((1S,3S)-3-hydroxy-cyclopentyl)-1-pyrrolidin-1-yl-ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL368156; BDBM50141664
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(3-Fluoro-phenyl)-carbamic acid (1R,3S)-3-((R)-1-amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclopentyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL172624; BDBM50141639
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
1-[3-(Imidazole-1-carbonyl)-2-aza-bicyclo[2.2.2]oct-2-yl]-4-phenyl-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309781; BDBM50051521
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
4-[(1R,3R)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentylsulfamoyl]-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL169962; BDBM50141623
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]butanoyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086264; BDBM50242264
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(3-(pyrrolidin-1-yl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL566616; SCHEMBL8274501; BDBM50302960
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
N-[2-[(2S)-2-Cyano-4-methylpyrrolidin-1-yl]-2-oxoethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2021934; BDBM50382284
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(S)-2-Amino-2-((1S,3R)-3-methoxy-cyclohexyl)-1-pyrrolidin-1-yl-ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL352632; BDBM50141646
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[(2R)-1-[(2S)-2-Cyanopyrrolidin-1-yl]-3-hydroxy-1-oxopropan-2-yl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233538; SCHEMBL15129756; BDBM50009313
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4,4-difluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243153; SCHEMBL3395679; BDBM50326392
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[(5S)-3-oxo-5-(hydroxymethyl)piperazino]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616896
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S,4S)-4-Fluoro-1-(2-((1S,5R,6s)-3-(5-(trifluoromethyl)pyridin-2-yl)-3-aza-bicyclo[3.1.0]hexan-6-ylamino)acetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL480324; BDBM50251465
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-1-[(5-methyl-2-phenyltriazol-4-yl)methyl]-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616907
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-8-piperazin-1-yl-1-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616909
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-But-2-ynyl-8-ethoxy-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616893
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(1S,3R)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-4-methanesulfonyl-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL433732; BDBM50141626
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[2-[(2S,4S)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022525; BDBM50382278
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(3-Fluoro-phenyl)-carbamic acid (1R,3S)-3-((S)-1-amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclopentyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL172631; BDBM50141633
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[(1R,3R)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-4-trifluoromethoxy-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168866; BDBM50141620
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[(1R,3S)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-4-trifluoromethoxy-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL366751; BDBM50141655
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616915
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090635; BDBM50242274
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
US9346814, Ref. Cmpd No 4
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3896942; BDBM233325
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
3,7-Dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616914
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S,4S)-4-Fluoro-1-(2-((1S,5R,6s)-3-(thiazol-2-yl)-3-aza-bicyclo[3.1.0]hexan-6-ylamino)acetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL479983; BDBM50251854
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
4-N-[(1S,3R)-3-[(1S)-1-Amino-2-oxo-2-pyrrolidin-1-ylethyl]cyclopentyl]benzene-1,4-disulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL171290; BDBM50141624
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopiperidin-1-yl]-2-oxoethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022534; BDBM50382259
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(3-morpholino-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL585129; SCHEMBL8276250; BDBM50302959
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2,6-Dichloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022511; BDBM50382265
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-[2-[(2S,4S)-2-Cyano-4-(trifluoromethyl)pyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022533; BDBM50382255
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S,4S)-4-Fluoro-1-(2-((1S,5R,6s)-3-(4-(trifluoromethyl)pyrimidin-2-yl)-3-aza-bicyclo[3.1.0]hexan-6-ylamino)acetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482262; BDBM50251853
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
1-(Quinoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616902; BDBM50277300
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
6-((1S,5R,6s)-6-(2-((2S,4S)-2-Cyano-4-fluoropyrrolidin-1-yl)-2-oxoethylamino)-3-aza-bicyclo[3.1.0]hexan-3-yl)nicotinonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL519265; BDBM50251466
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
7-But-2-ynyl-1-[[2-(hydroxymethyl)-1,3-thiazol-4-yl]methyl]-3-methyl-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616888
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[2-(acetylamino)ethylamino]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616898
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[4-[(7-But-2-ynyl-3-methyl-2,6-dioxo-8-piperazin-1-ylpurin-1-yl)methyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616906
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(4-Methoxy-phenyl)-carbamic acid (1S,3S)-3-((S)-1-amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclohexyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL433533; BDBM50141643
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-1-(naphthalen-2-ylmethyl)-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616903
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385283; BDBM50434186
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
1-(4-Methoxyquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616901; BDBM50277301
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2H-triazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233565; SCHEMBL15139038; BDBM50009346; (S)-N-(2-(2-cyanopyrrolidine-1-yl)-2-oxoethyl)-1H-1,2,3-triazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[2-[(2S)-2-Cyano-4-methylidenepyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022531; BDBM50382257
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL566672; SCHEMBL8272828; BDBM50302957
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[2-(4-pyridylcarbonylamino)ethylamino]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616899
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-propan-2-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616913
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2R)-2-[4-[[[(2S)-1-(2-Amino-2-cyclohexylacetyl)pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183418
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[(6S)-1,4-diazabicyclo[4.3.0]nonane-4-yl]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616891
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Methanesulfonylamino-ethanesulfonic acid [(1R,3R)-3-((S)-1-amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL439836; SCHEMBL1070623; BDBM50141641
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(3R)-3-Amino-1-(2-benzoyldiazinan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL535180
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(4-Iodo-phenyl)-carbamic acid (1S,3S)-3-((S)-1-amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL170051; BDBM50141619
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-3-ylmethyl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616911
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-Benzyl-1-[(4-methoxyquinazolin-2-yl)methyl]-3-methyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616920
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616895
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616890; SCHEMBL1772451; BDBM50277311; 1-[(4-Methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(piperazin-1-yl)-xanthine; 7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(1R,3R)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-4-methanesulfonyl-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL169204; SCHEMBL846004; BDBM50141615
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL566419; SCHEMBL8272715; BDBM50302967
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
1-[(4-Methoxyquinazolin-2-yl)methyl]-3,7-dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616916
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]pentanoyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078112; BDBM50242265
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
Unii-Z82X63Q1Z5
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Z82X63Q1Z5; CHEMBL3616894; Linagliptin metabolite m515(1)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(1S,3S)-3-[(1S)-1-Amino-2-oxo-2-pyrrolidin-1-ylethyl]cyclopentyl]-2-(methanesulfonamido)ethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL352548; BDBM50141654
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
3-[(7-But-2-ynyl-3-methyl-2,6-dioxo-8-piperazin-1-ylpurin-1-yl)methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616905
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[[7-But-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-2,6-dioxopurin-8-yl]amino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616897
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
US9346814, Cmpd No 37 Example 42
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233566; SCHEMBL15129600; BDBM233324; BDBM50009347; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-1,2,4-triazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-(Quinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616900; BDBM50277317
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(S)-2-Amino-2-((1S,3R)-3-hydroxy-cyclopentyl)-1-pyrrolidin-1-yl-ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL355244; BDBM50141632
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(2S)-1-[2-(4-Phenyltriazol-1-yl)acetyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233550; BDBM50009327
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2S,4S)-1-(2-((1S,5R,6s)-3-(Benzo[d]oxazol-2-yl)-3-aza-bicyclo[3.1.0]hexan-6-ylamino)acetyl)-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL480537; BDBM50251411
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Tert-butyl 4-[1-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]triazol-4-yl]piperazine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022522; BDBM50382275
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(4-Methoxy-phenyl)-carbamic acid (1S,3S)-3-((S)-1-amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL352737; BDBM50141651
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(5-tert-butyl-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL568111; BDBM50302973
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2S)-1-[2-[4-(4-Fluorophenyl)triazol-1-yl]acetyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233551; BDBM50009328
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-(2-Pyridylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616910
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(1S,3S)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-2-methanesulfonyl-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL355248; BDBM50141630
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[2-[(2S,4R)-4-Azido-2-cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022527; BDBM50382280
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-[4-(1H-Pyrazole-1-yl)benzyl]-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616908
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(S)-2-Amino-2-((1S,3S)-3-hydroxy-cyclohexyl)-1-pyrrolidin-1-yl-ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL355051; BDBM50141661
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(2S)-1-[2-[4-[3-(1,3-Dihydroisoindol-2-yl)-3-oxopropyl]triazol-1-yl]acetyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233552; BDBM50009329
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(4-Iodo-phenyl)-carbamic acid (1S,3R)-3-((S)-1-amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL172276; BDBM50141628
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
CID 89704940
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233574; SCHEMBL15129575; BDBM50009356
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-(4-Methoxyquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616917
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,3,4,5,6-pentafluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183289
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL565600; SCHEMBL8272829; BDBM50302972
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
N-[(1S,3S)-3-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclopentyl]-4-methanesulfonyl-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168986; BDBM50141658
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-4-ylmethyl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616912
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-[(4-Methoxyquinazolin-2-yl)methyl]-3-methyl-7-(4-methylpent-3-enyl)-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616919
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S,4S)-1-(2-((1S,5R,6s)-3-(2-Cyano-4-(trifluoromethyl)phenyl)-3-aza-bicyclo[3.1.0]hexan-6-ylamino)acetyl)-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL480781; BDBM50251789
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopiperidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2022535; BDBM50382286
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Methyl 2-[4-[[[(4R)-3-[3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186482
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[22] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-8-piperidin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616892; SCHEMBL15083818
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL566628; SCHEMBL8272746; BDBM50302964
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(3R,4R,4Ar,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-methyl 3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236075; BDBM50241263; methyl ester of 11-keto-beta-boswellic acid; 3alpha-Hydroxy-11-oxours-12-ene-24-oic acid methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 114750 nM
|
[12] | |||
| Compound Name |
Benzyl N-[(3aS,4R,7aR)-4-cyano-3-oxo-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818697; BDBM50180674
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[15] | |||
| Compound Name |
N-[(3Ar,4S,7aS)-4-[(2S)-2-cyanopyrrolidine-1-carbonyl]-3-oxo-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]-2-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3819297; BDBM50180675
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[15] | |||
| Compound Name |
(2S)-1-[(3Ar,4S,7aS)-3-oxo-2-phenylmethoxy-3a,4,5,7a-tetrahydro-1H-isoindole-4-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3819233; BDBM50180682
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[15] | |||
| Compound Name |
Benzyl N-[(3aR,4S,5R,7aS)-4-[(2S)-2-cyanopyrrolidine-1-carbonyl]-5-methyl-3-oxo-3a,4,5,7a-tetrahydro-1H-isoindol-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3818703; BDBM50180676
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[15] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Rutin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
RUTIN; 153-18-4; rutoside; Phytomelin; Quercetin 3-rutinoside; Birutan; Eldrin; Rutin trihydrate; Myrticolorin; Venoruton; Bioflavonoid; Paliuroside; Tanrutin; Osyritrin; Rutine; Rutozyd; 3-Rutinosyl quercetin; 3-Rhamnoglucosylquercetin; Quercetin 3-O-rutinoside; Rutosido; Rutosidum; Rutinum; Globularicitrin; Quercetin-3-rutinoside; Rutabion; Violaquercitrin; Globulariacitrin; Melin; Rutinic acid; Birutan Forte; Birutin; Quercetin rhamnoglucosine; Quercetin-3beta-rutinoside; UNII-5G06TVY3R7; Oxyritin; Rutosid; Ilixanthin; Rutinion acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[24] | |||
| Compound Name |
KAEMPFEROL
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
kaempferol; 520-18-3; Kaempherol; Kempferol; Trifolitin; Populnetin; Robigenin; Rhamnolutein; Pelargidenolon; Rhamnolutin; Swartziol; Indigo Yellow; Kampherol; Nimbecetin; Kampferol; Campherol; Kaemferol; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7,4'-Trihydroxyflavonol; Pelargidenolon 1497; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; C.I. 75640; CCRIS 41; NSC 407289; 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphe
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[24] | |||
| Compound Name |
3,7-dihydroxy-flavone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3,7-dihydroxyflavone; 7-Hydroxyflavonol; 492-00-2; 3,7-dihydroxy-2-phenyl-4H-chromen-4-one; 5-Deoxygalangin; 4H-1-Benzopyran-4-one, 3,7-dihydroxy-2-phenyl-; UNII-O948D0K9BQ; O948D0K9BQ; CHEMBL210276; 3,7-dihydroxy-2-phenylchromen-4-one; 3,7-dihydroxy-flavone; 7,3'-dihydroxyflavonol; SR-01000314616; Resogalangin; SPBio_001803; Spectrum_001462; SpecPlus_000778; AC1NU2BD; Spectrum4_001767; Spectrum3_001623; Spectrum2_001652; Spectrum5_000353; 3,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one; Oprea1_793720; KBioSS_001942; KBioGR_002253
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[24] | |||
| Compound Name |
(3R)-3-Amino-1-(2-benzoyldiazepan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539611
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[23] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Selective inhibitors of fibroblast activation protein (FAP) with a xanthine scaffold. Medchemcomm. 2014;5:1700-7. | ||||
| REF 2 | Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors. J Med Chem. 2010 May 13;53(9):3423-38. | ||||
| REF 3 | Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes. J Med Chem. 2014 Apr 24;57(8):3205-12. | ||||
| REF 4 | Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity. Bioorg Med Chem Lett. 2012 May 15;22(10):3412-7. | ||||
| REF 5 | 2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): a potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A. Bioorg Med Chem. 2011 Sep 15;19(18):5490-9. | ||||
| REF 6 | Structural revision of kynapcin-12 by total synthesis, and inhibitory activities against prolyl oligopeptidase and cancer cells. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3373-6. | ||||
| REF 7 | Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). J Med Chem. 2014 Apr 10;57(7):3053-74. | ||||
| REF 8 | Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors. J Med Chem. 1999 Mar 25;42(6):1041-52. | ||||
| REF 9 | US patent application no. 9346814B2, FAP inhibitors | ||||
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