Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85944 | Target Info | |||
| Target Name | Pseudomonas UDP-3-O-acyl-GlcNAc deacetylase (Pseudo lpxC) | ||||
| Synonyms |
Pseudo UDP-3-O-acyl-GlcNAc deacetylase; EnvA protein
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| Target Type | Preclinical Target | ||||
| Gene Name | Pseudo lpxC | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(2-Hydroxy-1-hydroxycarbamoyl-ethyl)-4-methyl-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL105660; BDBM50115479; N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methylbenzamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-Fluoro-N-(2-hydroxy-1-hydroxycarbamoyl-ethyl)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL104002; BDBM50115453; 4-fluoro-N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)benzamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Hydroxy-2-p-tolyl-5,6-dihydro-4h-1,3-oxazine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL107405; BDBM50115476; 2-p-Tolyl-5,6-dihydro-4H-[1,3]oxazine-4-carboxylic acid hydroxyamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(2-Hydroxy-1-hydroxycarbamoyl-ethyl)-4-methoxy-3-propyl-5-trifluoromethoxy-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL107025; BDBM50115451; N-(3-hydroxy-1-(hydroxyamino)-1-oxopropan-2-yl)-4-methoxy-3-propyl-5-(trifluoromethoxy)benzamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(4-(But-3-enyloxy)phenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL322571; BDBM50115440; 2-(4-But-3-enyloxy-phenyl)-4,5-dihydro-thiazole-4-carboxylic acid hydroxyamide
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| Activity |
IC50 = 58700 nM
|
[1] | |||
| Compound Name |
N-Hydroxy-2-(5-methyl-1-phenylpyrazol-4-yl)-4,5-dihydro-1,3-thiazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL107174; BDBM50115469; 2-(5-Methyl-1-phenyl-1H-pyrazol-4-yl)-4,5-dihydro-thiazole-4-carboxylic acid hydroxyamide
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| Activity |
IC50 ~ 60000 nM
|
[1] | |||
| Compound Name |
2-(4-Fluorophenyl)-N-hydroxy-4,5-dihydrothiazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104175; BDBM50115481; 2-(4-Fluoro-phenyl)-4,5-dihydro-thiazole-4-carboxylic acid hydroxyamide
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| Activity |
IC50 = 62500 nM
|
[1] | |||
| Compound Name |
N,4-Dihydroxy-1-[[4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]phenoxy]methyl]cyclohexane-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3356587; BDBM50497641
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| Activity |
IC50 = 82500 nM
|
[2] | |||
| Compound Name |
N-Hydroxy-4-[(4-phenoxyphenoxy)methyl]oxane-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3356190; BDBM50497648
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| Activity |
IC50 = 92000 nM
|
[2] | |||
| Compound Name |
N-Hydroxy-4-[[4-(5-hydroxy-5-methylhexa-1,3-diynyl)phenoxy]methyl]oxane-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3356192; BDBM50497653
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| Activity |
IC50 = 139000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC. J Med Chem. 2002 Jul 4;45(14):3112-29. | ||||
| REF 2 | Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. ACS Med Chem Lett. 2014 Sep 23;5(11):1213-8. | ||||
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