Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85733 | Target Info | |||
| Target Name | DNA topoisomerase II beta (TOP2B) | ||||
| Synonyms |
Topo IIbeta; TOP2beta; TOP2B
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| Target Type | Successful Target | ||||
| Gene Name | TOP2B | ||||
| Biochemical Class | ATP-hydrolyzing DNA topoisomerase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 16 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Etoposide
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Approved | Compound Info | ||
| Synonyms |
etoposide; 33419-42-0; VePesid; Toposar; trans-Etoposide; Lastet; (-)-Etoposide; Zuyeyidal; Etoposidum; Etoposido; Vepesid J; Eposin; Etoposidum [INN-Latin]; Etoposide (VP16); VP 16-213; VP 16 (pharmaceutical); Etoposido [INN-Spanish]; Etopophos (phosphate salt); VP-16-213; 4-Demethylepipodophyllotoxin beta-D-ethylideneglucoside; VP 16213; UNII-6PLQ3CP4P3; NK 171; NSC 141540; CCRIS 2392; HSDB 6517; 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside); EINECS 251-509-1; NSC-141540; Eposide; Etopol; Etosid; Vepeside; Demethyl EpipodophyllotoxinEthylidine Glucoside; E0675; Demethyl-epiodophyllotoxin ethylidene glucoside; Epipodophyllotoxin VP-16213; Eposin (TN); Etopophos (TN); Trans-Etoposide; VePESID (TN); Vepesid (TN); DEMETHY-EPIPODOPHYLLOTOXIN, ETHYLIDENE GLUCOSIDE; VP-16 (TN); Demethylepipodophyllotoxin-beta-D-ethylideneglucoside; Etoposide (JP15/USP/INN); Etoposide [USAN:INN:BAN:JAN]; Eposin, Vepesid, VP-16, Toposar, Etoposide; Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside; Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside (8CI); Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-beta-D-glucopyranoside); 4'-Demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside; 4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside); 4'-Demethylepipodophyllotoxin ethylidene-beta-D-glucoside; 4'-O-Demethyl-1-O-(4,6-O-ethylidene-beta-D-glucopyranosyl)epipodophyllotoxin; 4-Demethylepipodophyllotoxin-beta-D-ethylideneglucoside
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| Activity |
EC50 ~ 70000 nM
|
[1] | |||
| Compound Name |
5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-(tetrahydro-pyran-4-yl)-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL421899; BDBM50286485
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(4-Amino-cyclohexyl)-5-cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL132098; CHEMBL445908; SCHEMBL9308458; SCHEMBL9310236; SCHEMBL9310248; BDBM50286492; BDBM50286496
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-(1-methyl-piperidin-4-yl)-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL129908; BDBM50286491
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Cyclopropyl-2-(4-dimethylamino-cyclohexyl)-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL131262; CHEMBL336549; NCI60_016687; CTK6C3999; BDBM50286488; BDBM50286494
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Cyclopropyl-2-(3-dimethylamino-propyl)-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL131677; BDBM50286501
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-(4-methyl-cyclohexyl)-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL131600; BDBM50286489
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-Cyclohexyl-5-cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL130627; BDBM50286484
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-{4-[5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-3-oxo-3,5-dihydro-pyrazolo[4,3-c]quinolin-2-yl]-cyclohexyl}-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL130332; CHEMBL337180; BDBM50286497; BDBM50286498
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| Activity |
EC50 ~ 51000 nM
|
[1] | |||
| Compound Name |
1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxyic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL8179; WIN-57294; Cpfdm-3-qca; SCHEMBL9310002; DTXSID20154155; BDBM50045698
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| Activity |
EC50 ~ 54000 nM
|
[1] | |||
| Compound Name |
1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-1H-quinolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL414022; BDBM50045706; 1,4-Dihydro-1-cyclopropyl-4-oxo-6,8-difluoro-7-(2,6-dimethylpyridin-4-yl)quinoline
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| Activity |
EC50 ~ 55000 nM
|
[1] | |||
| Compound Name |
[5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-3-oxo-3,5-dihydro-pyrazolo[4,3-c]quinolin-2-yl]-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL334386; SCHEMBL9311144; BDBM50286493
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| Activity |
EC50 ~ 60000 nM
|
[1] | |||
| Compound Name |
5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-(2-hydroxy-ethyl)-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL133757; BDBM50286500
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| Activity |
EC50 ~ 60000 nM
|
[1] | |||
| Compound Name |
5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL335683; BDBM50286474
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| Activity |
EC50 ~ 60000 nM
|
[1] | |||
| Compound Name |
5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-2-methyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL133466; BDBM50286499
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| Activity |
EC50 ~ 60000 nM
|
[1] | |||
| Compound Name |
[5-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-difluoro-3-oxo-3,5-dihydro-pyrazolo[4,3-c]quinolin-2-yl]-acetic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL133784; BDBM50286487
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| Activity |
EC50 ~ 60000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The antitumor activity of novel pyrazoloquinoline derivatives. Bioorg Med Chem Lett. 1995 Feb 16;5(4):405-10. | ||||
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