Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85581 | Target Info | |||
| Target Name | Na-K-Cl cotransporter (NKCC) | ||||
| Synonyms |
Solute carrier family 12; Na-K-Cl symporter; NKCC; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter
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| Target Type | Clinical trial Target | ||||
| Gene Name | SLC12A1; SLC12A2 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
VU0240551
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Investigative | Compound Info | ||
| Synonyms |
893990-34-6; VU 0240551; VU0240551; N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-acetamide; VU0240551-2-D4; N-(4-methylthiazol-2-yl)-2-(6-phenylpyridazin-3-ylthio)acetamide; VU-0240551; n-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide; VU0240551-1; N-(4-methyl-1,3-thiazol-2-yl)-2-[(6-phenylpyridazin-3-yl)thio]acetamide; C16H14N4OS2; C26H30N2O5; N-(4-methyl-1,3-thiazol-2-yl)-2-(6-phenylpyridazin-3-yl)sulfanylacetamide; AC1OHJ6T; MLS000621247; GTPL4665; CHEMBL1491962; SCHEMBL20240442; BDBM43891
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| Activity | Basolateral Na-K-Cl symporter |
IC50 ~ 50000 nM
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[1] | ||
| Compound Name |
N-Methyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
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Investigative | Compound Info | ||
| Synonyms |
ML077; ML-077; CHEMBL2048846; VU0255011-1; AOB1523; BDBM50387285; ZINC84669029; AS-16660; J3.616.798J; BRD-K90705745-001-01-8; Q27165275
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| Activity | Basolateral Na-K-Cl symporter |
IC50 ~ 50000 nM
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[1] | ||
| References | Top | ||||
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| REF 1 | Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4532-5. | ||||
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