Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85574 | Target Info | |||
| Target Name | Angiotensin II receptor (AGTR) | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4'-[(2-Butyl-1H-indol-1-yl)methyl]-1,1'-biphenyl-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL171875; BDBM50230423
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| Activity |
IC50 = 51000 nM
|
[1] | |||
| Compound Name |
Methyl 2-[4-[(2-butylimidazo[4,5-d]pyridazin-5-yl)methyl]phenyl]benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL268822; BDBM50212839
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
4'-[(Benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL422562; SCHEMBL8396472; BDBM50230433; ZINC13451134; 2-[4-(benzimidazol-1-ylmethyl)phenyl]benzoic acid; 4'-[(1H-Benzimidazol-1-yl)methyl]-1,1'-biphenyl-2-carboxylic acid
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| Activity |
IC50 = 140000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | New nonpeptide angiotensin II receptor antagonists. 1. Synthesis, biological properties, and structure-activity relationships of 2-alkyl benzimidazole derivatives. J Med Chem. 1992 Mar 6;35(5):877-85. | ||||
| REF 2 | The synthesis of heterosubstituted benzimidazole derivatives with potent angiotensin II antagonist activity. Bioorg Med Chem Lett. 1993 Jun;3(6):1019-24. | ||||
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