Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T85421 | Target Info | |||
| Target Name | Jun N terminal kinase (JNK) | ||||
| Synonyms |
c-Jun N-terminal kinase; Stress-activated protein kinase JNK; SAPK1; PRKM; MAP kinase; JNK
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| Target Type | Clinical trial Target | ||||
| Gene Name | MAPK8; MAPK9; MAPK10 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL104074; CHEMBL104466; RP-127963; 4-[(6,7-dimethoxyquinoxalin-2-yl)amino]cyclohexan-1-ol; SCHEMBL842647; SCHEMBL842648; SCHEMBL3393843; CTK0I9204; DTXSID30430871; Cyclohexanol, 4-[(6,7-dimethoxy-2-quinoxalinyl)amino]-, trans-; BDBM50132391; BDBM50132407; cis-4-(6, 7-Dimethoxyquinoxalin-2-ylamino)-cyclohexanol; cis-4-(6,7-Dimethoxyquinoxalin-2-ylamino)-cyclohexanol; 4-((R)-6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanol; Trans-4-((6,7-dimethoxyquinoxalin-2-yl)amino)cyclohexanol; trans-4-(6,7-dimethoxy-quinoxalin-2-ylamino)-cyclohexanol; 2-(4alpha-Hydroxycyclohexane-1alpha-ylamino)-6,7-dimethoxyquinoxaline; 2-(4beta-Hydroxycyclohexane-1alpha-ylamino)-6,7-dimethoxyquinoxaline
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
Urea, N-ethyl-N'-(3-((4-methylphenyl)amino)pyrido(2,3-b)pyrazin-6-yl)-
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Investigative | Compound Info | ||
| Synonyms |
D-106669; UNII-9575Q08390; D 106669; 9575Q08390; 1-ethyl-3-(3-(p-tolylamino)pyrido[2,3-b]pyrazin-6-yl)urea; SCHEMBL5447520; CHEMBL3185338; BDBM47095; DTXSID10239783; 1-ethyl-3-[3-(4-methylanilino)pyrido[2,3-b]pyrazin-6-yl]urea; BCP27662; ABP000091; ZINC34894475; AKOS032947253; NCGC00346447-01; NCGC00346447-02; DB-079721; FT-0715869; Z-3197; D106669;D106669; US8937068, 150; Q27271752
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-Ethyl-N-[(3-phenylpyrido[2,3-b]pyrazin-6-yl)carbamoyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5447732; CHEMBL3695619; BDBM142657; US8937068, 46
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
1-[3-(3,4-Dimethoxyanilino)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695652; SCHEMBL14506630; BDBM142694; US8937068, 187
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
1-Ethyl-3-[3-(pyridin-3-ylamino)pyrido[2,3-b]pyrazin-6-yl]urea
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5458507; CHEMBL3695631; BDBM142672; US8937068, 161
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3097-100. | ||||
| REF 2 | US patent application no. 8937068B2, Pyridopyrazine derivatives and their use | ||||
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