Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85309 | Target Info | |||
| Target Name | Cystathionine beta-synthase (CBS) | ||||
| Synonyms |
Serine sulfhydrase; Beta-thionase
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| Target Type | Clinical trial Target | ||||
| Gene Name | CBS | ||||
| Biochemical Class | Alpha-carbonic anhydrase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 8 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4,5-Dibromo-1H-pyrrole-2-carboxylic acid amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL356164; 34649-20-2; 4,5-dibromopyrrole-2-carboxamide; 4,5-dibromo-1h-pyrrole-2-carboxamide; 4,5-dibromopyrrole-2-carbonamide; 4,5-Dibromo-1H-pyrrole-2-carboxylic acid amide; MLS001250248; 4,5-dibromopyrrole-2-carbamide; CTK1B1045; DTXSID30555154; BDBM50108773; SMR001216076; 1H-Pyrrole-2-carboxamide, 4,5-dibromo-; 4,5-Dibromo-1H-pyrrole-2-carboxylic acid
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| Activity |
IC50 = 156000 nM
|
[1] | |||
| Compound Name |
2-Thioxo-5-[(Z)-3-methoxy-4-acetoxybenzylidene]imidazolidine-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403661; BDBM50064289; BHT102804; 2-methoxy-4-{[(4Z)-5-oxo-2-sulfanylideneimidazolidin-4-ylidene]methyl}phenyl acetate
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| Activity |
IC50 = 83000 nM
|
[1] | |||
| Compound Name |
(5Z)-5-[(4-Hydroxy-3-methoxyphenyl)methylidene]-3-methyl-2-methylsulfanylimidazol-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403662; BDBM50064264
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| Activity |
IC50 = 87000 nM
|
[1] | |||
| Compound Name |
Rubrolide A
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Investigative | Compound Info | ||
| Synonyms |
(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-5-[(3,5-dibromo-4-hydroxyphenyl)methylidene]furan-2-one; CHEMBL511842; SCHEMBL12402314; BDBM50064292; NSC701303; NSC-701303; 3',3'',5',5''-Tetrabromorubrolide E
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| Activity |
IC50 = 108000 nM
|
[1] | |||
| Compound Name |
(5Z)-5-[(3,4-Dihydroxyphenyl)methylidene]-2-sulfanylideneimidazolidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956805; (5Z)-5-(3,4-dihydroxybenzylidene)-2-thioxoimidazolidin-4-one; SCHEMBL15421565; SCHEMBL15421567; BDBM50064290; BHT100759; STK375881; AKOS005228040; ZINC102124929; ST50898039; 2-Thioxo-5-[(Z)-3,4-dihydroxybenzylidene]imidazolidine-4-one; 5-[(3,4-dihydroxyphenyl)methylene]-2-thioxo-1,3-diazolidin-4-one
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| Activity |
IC50 = 125000 nM
|
[1] | |||
| Compound Name |
Sodium;[(1S)-1-methyl-12,17-dioxo-14-oxapentacyclo[11.6.1.02,11.04,9.016,20]icosa-2(11),3,5,7,9,13(20),15-heptaen-5-yl] sulfate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403663; BDBM50064263
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| Activity |
IC50 = 136000 nM
|
[1] | |||
| Compound Name |
5-Benzylidene-2-thiohydantoin
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Investigative | Compound Info | ||
| Synonyms |
HYDANTOIN, 5-BENZYLIDENE-2-THIO-; CHEMBL1956777; NSC684359; 5-Benzylidene-2-thioguidanthion; NSC7937; 5-(phenylmethylene)-2-thioxo-1,3-diazolidin-4-one; 5-Benzal-2-thlohydantoin; (5Z)-5-benzylidene-2-sulfanylideneimidazolidin-4-one; SCHEMBL12706773; 4-Imidazolidinone, 5-(phenylmethylene)-2-thioxo-, (5Z)-; HMS1772A07; (z)-5-benzylidene-2-thiohydantoin; NSC-7937; SMSF0004024; ZINC1586318; BDBM50064265; BHT102154; STK396887; AKOS001136865; CB01973; NSC-684359; SDCCGMLS-0064508.P001; ST003013; BIM-0012968.P001; (5Z)-5-benzylidene-2-thioxoimidazolidin-4-one; (5Z)-2-Thioxo-5-benzylideneimidazolidine-4-one; (5Z)-5-benzylidene-2-thioxo-imidazolidin-4-one; AB00376743-02; (5Z)-5-Benzylidene-2-thioxo-4-imidazolidinone #; SR-01000197415; SR-01000197415-1; (5Z)-5-(PHENYLMETHYLIDENE)-2-SULFANYLIDENEIMIDAZOLIDIN-4-ONE
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| Activity |
IC50 = 170000 nM
|
[1] | |||
| Compound Name |
(5Z)-5-[(4-Hydroxy-3-methoxyphenyl)methylidene]-2-sulfanylideneimidazolidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1957775; SCHEMBL15421414; SCHEMBL15421418; BDBM50064291; BHT103470; STL428161; AKOS003001877; ZINC100902383; ST50986424; AB00086857-01; SR-01000210797; SR-01000210797-1; (5Z)-5-(4-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one; 2-Thioxo-5-[(Z)-3-methoxy-4-hydroxybenzylidene]imidazolidine-4-one; 5-[(4-hydroxy-3-methoxyphenyl)methylene]-2-thioxo-1,3-diazolidin-4-one
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| Activity |
IC50 = 187000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Marine natural products as inhibitors of cystathionine beta-synthase activity. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1064-6. | ||||
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