Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85221 | Target Info | |||
| Target Name | Glucose-6-phosphatase (G6PC) | ||||
| Synonyms |
Glucose-6-phosphatase alpha; G6Pase-alpha; G6Pase; G6PT; G-6-Pase
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| Target Type | Clinical trial Target | ||||
| Gene Name | G6PC | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-Benzyl-N-[(E)-(6-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)amino]-1-phenylmethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL68981; BDBM50103116; N,N-Dibenzyl-N''-[6-methoxy-3,4-dihydro-2H-naphthalen-(1E)-ylidene]-hydrazine
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-Amino-4-(2,4-dimethoxyphenyl)-5-(4-fluorophenyl)-6-methylsulfanylbenzene-1,3-dicarbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL521291; BDBM50277824
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| Activity |
IC50 = 79000 nM
|
[2] | |||
| Compound Name |
[4-(Dibenzyl-hydrazonomethyl)-phenyl]-dimethyl-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL69758; BDBM50103113
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N,N-Dibenzyl-N''-[1-(5-nitro-furan-2-yl)-meth-(E)-ylidene]-hydrazine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL69742; SCHEMBL8496852; BDBM50103127
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N,N-Dibenzyl-N''-[1-(3,5-dichloro-phenyl)-meth-(E)-ylidene]-hydrazine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL302496; BDBM50103117
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N,N-Dibenzyl-N''-[2-phenyl-eth-(E)-ylidene]-hydrazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL68153; BDBM50103123
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N,N-Dibenzyl-N''-[1-(2-methoxy-phenyl)-meth-(E)-ylidene]-hydrazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304503; BDBM50103108
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | N,N-dibenzyl-N'-benzylidenehydrazines: potent competitive glucose-6-phosphatase catalytic enzyme inhibitors. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2165-7. | ||||
| REF 2 | 5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2158-61. | ||||
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