Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84791 | Target Info | |||
| Target Name | JUN activation domain binding protein (COPS5) | ||||
| Synonyms |
Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
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| Target Type | Literature-reported Target | ||||
| Gene Name | COPS5 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(Pyridin-2-ylmethyl)-8-[[3-(pyridin-2-ylmethylcarbamoyl)quinolin-8-yl]disulfanyl]quinoline-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062208; SCHEMBL18526848; BDBM50264459
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Methyl-8-[[3-(methylcarbamoyl)quinolin-8-yl]disulfanyl]quinoline-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103171; SCHEMBL18526863; BDBM50264423
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| Activity |
IC50 = 68000 nM
|
[1] | |||
| Compound Name |
N-[2-(1,3-Thiazol-2-yl)ethyl]-8-[[7-[2-(1,3-thiazol-2-yl)ethylcarbamoyl]-1,5-naphthyridin-4-yl]disulfanyl]-1,5-naphthyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085174; BDBM50264427
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-(2-Morpholin-4-ylethyl)-8-[[3-(2-morpholin-4-ylethylcarbamoyl)quinolin-8-yl]disulfanyl]quinoline-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059915; SCHEMBL18526838; BDBM50264516
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Methylquinoline-8-thiol
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Investigative | Compound Info | ||
| Synonyms |
8-Quinolinethiol, 2-methyl-; CHEMBL4083010; 2-methyl-8-mercaptochinolin; SCHEMBL1914441; CTK0G7734; DTXSID80461554; BDBM50264502; ZINC12462690
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-(Pyridin-3-ylmethyl)-8-[[3-(pyridin-3-ylmethylcarbamoyl)quinolin-8-yl]disulfanyl]quinoline-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083926; SCHEMBL18526841; BDBM50264418
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[[4-(Trifluoromethyl)phenyl]methyl]-8-[[3-[[4-(trifluoromethyl)phenyl]methylcarbamoyl]quinolin-8-yl]disulfanyl]quinoline-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069023; SCHEMBL18526847; BDBM50264416
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
8-Methylsulfanyl-N-[2-(1,3-thiazol-2-yl)ethyl]quinoline-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070030; SCHEMBL18539664; BDBM50264428
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
8-Hydroxy-N-[2-(1,3-thiazol-2-yl)ethyl]quinoline-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091004; BDBM50264449
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Methyl 2-[[8-[[3-[(2-methoxy-2-oxoethyl)carbamoyl]quinolin-8-yl]disulfanyl]quinoline-3-carbonyl]amino]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086748; BDBM50264482
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J Med Chem. 2017 Feb 23;60(4):1343-1361. | ||||
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