Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84553 | Target Info | |||
| Target Name | Adenosine monophosphate deaminase (AMPD) | ||||
| Synonyms |
AMP deaminase
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| Target Type | Literature-reported Target | ||||
| Gene Name | AMPD1; AMPD2; AMPD3 | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 17 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(4-Hydroxy-butyl)-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL37531; BDBM50087326
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| Activity | Adenosine monophosphate deaminase 2 |
Ki = 53000 nM
|
[1] | ||
| Compound Name |
7-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-heptanoic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL37053; BDBM50087320; 8-Hydroxy-7,8-dihydroimidazo[4,5-d][1,3]diazepine-3(6H)-heptanoic acid ethyl ester
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| Activity | Adenosine monophosphate deaminase 2 |
Ki = 55000 nM
|
[1] | ||
| Compound Name |
6-(8-Hydroxy-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-3-yl)hexylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL34434; BDBM50087305; [6-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-hexyl]-phosphonic acid 2H2O
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| Activity | Adenosine monophosphate deaminase 2 |
Ki = 55000 nM
|
[1] | ||
| Compound Name |
5-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-pentanoic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL37174; BDBM50087330; 8-Hydroxy-7,8-dihydroimidazo[4,5-d][1,3]diazepine-3(6H)-pentanoic acid methyl ester
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| Activity | Adenosine monophosphate deaminase 2 |
Ki = 63000 nM
|
[1] | ||
| Compound Name |
3-(6-Hydroxyhexyl)-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL285201; BDBM50087300; 3-(6-Hydroxy-hexyl)-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol 0.5H2O
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| Activity | Adenosine monophosphate deaminase 2 |
Ki = 64000 nM
|
[1] | ||
| Compound Name |
3-(3-Hydroxy-propyl)-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL288438; BDBM50087315
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| Activity | Adenosine monophosphate deaminase 2 |
Ki = 68000 nM
|
[1] | ||
| Compound Name |
Imidazo[4,5-d][1,3]diazepin-8-ol, 3-butyl-3,4,7,8-tetrahydro-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL290339; BDBM50087318; 3-Butyl-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol
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| Activity | Adenosine monophosphate deaminase 2 |
Ki = 84000 nM
|
[1] | ||
| Compound Name |
4-[[(8-Hydroxy-7,8-dihydroimidazo[4,5-d][1,3]diazepine)-3(6H)-yl]methoxy]butanoic acid sodium salt
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL290418
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| Activity | Adenosine monophosphate deaminase 1 |
Ki = 85000 nM
|
[1] | ||
| Compound Name |
3-Propyl-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL289010; BDBM50087314
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| Activity | Adenosine monophosphate deaminase 2 |
Ki ~ 125000 nM
|
[1] | ||
| Compound Name |
3-Benzyl-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL37640; NSC300894; BDBM50087297; NSC-300894
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| Activity | Adenosine monophosphate deaminase 2 |
Ki ~ 125000 nM
|
[1] | ||
| Compound Name |
Sodium;5-(8-hydroxy-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-3-yl)pentanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL36488
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| Activity | Adenosine monophosphate deaminase 2 |
Ki ~ 125000 nM
|
[1] | ||
| Compound Name |
3-Ethyl-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL34128; BDBM50087335
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| Activity | Adenosine monophosphate deaminase 2 |
Ki ~ 125000 nM
|
[1] | ||
| Compound Name |
4-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-butyronitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL33894; BDBM50087302
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| Activity | Adenosine monophosphate deaminase 2 |
Ki ~ 125000 nM
|
[1] | ||
| Compound Name |
6-(8-Hydroxy-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-3-yl)hexyl-methoxyphosphinic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL36692; BDBM50087306
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| Activity | Adenosine monophosphate deaminase 2 |
Ki = 140000 nM
|
[1] | ||
| Compound Name |
3-(2-Hydroxy-ethyl)-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL36879; BDBM50087292
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| Activity | Adenosine monophosphate deaminase 2 |
Ki = 150000 nM
|
[1] | ||
| Compound Name |
7-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-heptanenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL36937; BDBM50087303
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| Activity | Adenosine monophosphate deaminase 1 |
Ki = 170000 nM
|
[1] | ||
| Compound Name |
6-(8-Hydroxy-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-3-yl)hexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL36951; BDBM50087308; 6-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-hexanoic acid amide 0.4H2O
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| Activity | Adenosine monophosphate deaminase 2 |
Ki = 180000 nM
|
[1] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-pentanenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL35156; BDBM50087323
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|
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| Activity | Adenosine monophosphate deaminase 2 |
Ki = 240000 nM
|
[1] | ||
| Compound Name |
3-(2-Imidazo[2,1-f][1,2,4]triazin-7-ylethyl)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042529; BDBM50385587
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|
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| Activity | Adenosine monophosphate deaminase 3 |
IC50 = 370000 nM
|
[2] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | AMP deaminase inhibitors. 2. Initial discovery of a non-nucleotide transition-state inhibitor series. J Med Chem. 2000 Apr 20;43(8):1495-507. | ||||
| REF 2 | Synthesis and Biochemical Testing of 3-(Carboxyphenylethyl)imidazo[2,1-f][1,2,4]triazines as Inhibitors of AMP Deaminase. ACS Med Chem Lett. 2010 Jun 18;1(6):286-9. | ||||
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