Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84397 | Target Info | |||
| Target Name | Tubulin beta-1 chain (TUBB1) | ||||
| Synonyms |
TUBB1
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| Target Type | Clinical trial Target | ||||
| Gene Name | TUBB1 | ||||
| Biochemical Class | Tubulin family | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
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Investigative | Compound Info | ||
| Synonyms |
Trans-Combretastatin A-4; E-Combretastatin A-4; CHEMBL36455; NSC609397; NSC613729; 2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol; 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol; 2-methoxy-5-(3,4,5-trimethoxystyryl)phenol; trans-(E)-Combretastatin; 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol; From Combretum caffrum plant; SCHEMBL18946; SCHEMBL9707931; ZINC1611146; BDBM50009561; CCG-35662; CCG-36400; AKOS015915109; ND-2980; NSC-609397; B817373K328; 3',4,4',5'-Tetramethoxy-cis-stilbene-3-ol; (E)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol; A803704; J-003498; 2-Methoxy-5-(2-(3,4,5-trimethoxyphenyl)vinyl)phenol; 2-Methoxy-5-[(E)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol; trans-2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol
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| Activity |
IC50 = 50000 nM
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[1] | |||
| Compound Name |
2-Methoxy-5-(3,4,5-trimethoxyanilino)phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL150463; BDBM50095319; 2-Methoxy-5-(3,4,5-trimethoxy-phenylamino)-phenol
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
[2-Methoxy-5-(3,4,5-trimethoxy-benzyloxy)-phenyl]-methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL153243; BDBM50095322
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
(E)-3-(3,4,5-Trihydroxyphenyl)-1-(2,3,4-trimethoxyphenyl)prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL192276; BDBM50159293; (E)-3-(3,4,5-Trihydroxy-phenyl)-1-(2,3,4-trimethoxy-phenyl)-propenone
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
3',4',5'-Trimethoxy-3,4-dihydroxychalcone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL126617; SCHEMBL13674866; BDBM50042990; 3,4-dihydroxy-3'',4'',5''-trimethoxychalcone; 3-(3,4-Dihydroxy-phenyl)-1-(3,4,5-trimethoxy-phenyl)-propenone; (E)-3-(3,4-Dihydroxy-phenyl)-1-(3,4,5-trimethoxy-phenyl)-propenone; 3-(3,4-dihydroxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one; (E)-3-(3'''',4''''-Dihydroxyphenyl)-1-(3'',4'',5''-trimethoxyphenyl)prop-2-en-1-one
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
3-[2-Methoxy-5-(3,4,5-trimethoxy-phenoxymethyl)-phenoxy]-propane-1,2-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL358037; BDBM50095316
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Quantitative structure-activity relationship (5D-QSAR) study of combretastatin-like analogues as inhibitors of tubulin assembly. J Med Chem. 2005 Jan 27;48(2):457-65. | ||||
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