Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T81850 | Target Info | |||
| Target Name | Squalene synthetase (FDFT1) | ||||
| Synonyms |
Squalene synthase; SS; SQS; Farnesyl-diphosphate farnesyltransferase; FPP:FPP farnesyltransferase
Click to Show/Hide
|
||||
| Target Type | Discontinued Target | ||||
| Gene Name | FDFT1 | ||||
| Biochemical Class | Alkyl aryl transferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
SQ-109
Click to Show/Hide
|
Phase 2 | Compound Info | ||
| Synonyms |
SQ-37; SQ-59; Antibiotics (tuberculosis), Sequella; Second-generation EMB, Sequella; Second-generation ethambutol, Sequella
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
{[(4,6-Dimethylpyridin-2-yl)amino]methanediyl}bis(phosphonic acid)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL52620; NSC723989; (4,1-bisphosphonate; CTK5D1686; DTXSID00328099; BDBM50138026; NSC-723989; (4,6-Dimethyl-2-pyridinylamino)methylenebisphosphonic acid; (4,6-dimethylpyridin-2-ylamino)methylenediphosphonic acid; 2-[(Bis-phosphono-methyl)-amino]-4,6-dimethyl-pyridinium; (4,6-dimethyl-2-pyridinyl)-aminomethylene-1,1-bisphosphonate; [(4,6-Dimethyl-pyridin-2-ylamino)-phosphono-methyl]-phosphonic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2E)-N-[2-(2-Adamantyloxy)ethyl]-3,7-dimethyl-2,6-octadiene-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261880; SCHEMBL16566227; BDBM50011479; (2E)-N-[2-(2-adamantyloxy)ethyl]-3,7-dimethyl-octa-2,6-dien-1-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-[2-[(2E)-3,7-Dimethylocta-2,6-dienoxy]ethyl]adamantan-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261881; SCHEMBL16566230; BDBM50011480; N-[2-[[(E)-3,7-Dimethyl-2,6-octadienyl]oxy]ethyl]adamantane-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
[[(6-Chloropyridin-3-yl)amino]-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL56078; N-6-chloro-(3-pyridyl)-aminomethylene-1,1-bisphosphonate; NSC723981; SCHEMBL7794868; CTK6H1476; BDBM50138023; NSC-723981; (6-chloropyridin-3-ylamino)methylenediphosphonic acid; {[(6-chloropyridin-3-yl)amino]methanediyl}bis(phosphonic acid); [(6-Chloro-pyridin-3-ylamino)-phosphono-methyl]-phosphonic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Multitarget drug discovery for tuberculosis and other infectious diseases. J Med Chem. 2014 Apr 10;57(7):3126-39. | ||||
| REF 2 | Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. J Med Chem. 2004 Jan 1;47(1):175-87. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.