Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T81311 | Target Info | |||
| Target Name | Endoplasmin (HSP90B1) | ||||
| Synonyms |
gp96 homolog; Tumor rejection antigen 1; TRA1; Heat shock protein 90 kDa beta member 1; GRP94; GRP-94; 94 kDa glucoseregulated protein; 94 kDa glucose-regulated protein
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| Target Type | Clinical trial Target | ||||
| Gene Name | HSP90B1 | ||||
| Biochemical Class | Heat shock protein | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[8-(2,4-Dimethoxyphenyl)sulfanyl-6-imino-7H-purin-3-yl]butanenitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3426770; BDBM50087651
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[8-(3,5-Dimethylphenyl)sulfanyl-6-imino-7H-purin-3-yl]butanenitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3426775; BDBM50087712
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[6-Imino-8-[2-(trifluoromethoxy)phenyl]sulfanyl-7H-purin-3-yl]butanenitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3426767; BDBM50087648
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Nc1ncn(CCCC#N)c2nc(Sc3cc(Cl)cc(Cl)c3)nc12
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3426774; SCHEMBL16487297; BDBM50087710
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4-[8-[2-Chloro-5-(trifluoromethyl)phenyl]sulfanyl-6-imino-7H-purin-3-yl]butanenitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3426773; BDBM50087705
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[6-Imino-8-(2-methoxyphenyl)sulfanyl-7H-purin-3-yl]butanenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3426765; BDBM50087577
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[8-[2-(Hydroxymethyl)phenyl]sulfanyl-6-imino-7H-purin-3-yl]butanenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3426766; BDBM50087578
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[8-(2,5-Dimethylphenyl)sulfanyl-6-imino-7H-purin-3-yl]butanenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3426772; BDBM50087662
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[8-(2-Chlorophenyl)sulfanyl-6-imino-7H-purin-3-yl]butanenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3426764; BDBM50087576
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. J Med Chem. 2015 May 14;58(9):3922-43. | ||||
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