Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T81183 | Target Info | |||
| Target Name | Adrenergic receptor Alpha-1 (ADRA1) | ||||
| Synonyms |
Alpha1-adrenoceptor; Alpha(1)-adrenoceptor
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(1H-Imidazol-2-yl)-quinoxalin-6-yl-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL74449; 6-Quinoxalinamine, N-1H-imidazol-2-yl-; (1H-Imidazol-2-yl)-quinoxalin-6-yl-amine; BDBM50055838
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
5,6-Isobenzofurandiol, 1-(aminomethyl)-1,3-dihydro-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL53335; SCHEMBL10923614; BDBM50225442
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| Activity |
Ki = 99000 nM
|
[2] | |||
| Compound Name |
2-Propan-2-ylbicyclo[2.2.1]heptan-3-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL430112; Lopac0_000109; SCHEMBL6777381; CTK6A4532; BDBM50050094; CCG-204204; 3-Isopropyl-bicyclo[2.2.1]hept-2-ylamine; 3-(propan-2-yl)bicyclo[2.2.1]heptan-2-amine
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| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
6-Quinoxalinamine, 5-bromo-N-1H-imidazol-2-yl-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1019; 5-bromo-N-(1H-imidazol-2-yl)quinoxalin-6-amine; Brimonidine EP Impurity F; 4,5-Didehydro Brimonidine; SCHEMBL7803704; BDBM50055828; (5-Bromo-quinoxalin-6-yl)-(1H-imidazol-2-yl)-amine; 4,5-Didehydro Brimonidine; 5-Bromo-N-1H-imidazol-2-yl-6-quinoxalinamine
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate
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Investigative | Compound Info | ||
| Synonyms |
CL 316,243; CL-316243; UNII-CF9MRO9QWW; CL-316243 sodium; CF9MRO9QWW; CL-316,243; 138908-40-4 (sodium salt); CL316243; BTA-243; CL 316243; CL316,243; CHEMBL32590; CL 316243 disodium; SCHEMBL2016430; DTXSID6041004; HMS3260L12; Tox21_500295; AKOS024456637; LP00295; NCGC00093745-01; NCGC00260980-01; AS-16747; EU-0100295; C 5976; 102718-EP2272841A1; 102718-EP2301936A1; Q27275433
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| Activity |
EC50 > 1000000 nM
|
[4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. | ||||
| REF 2 | Conformationally defined adrenergic agents. 4. 1-(aminomethyl)phthalans: synthesis and pharmacological consequences of the phthalan ring oxygen atom. J Med Chem. 1987 Jan;30(1):178-84. | ||||
| REF 3 | Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J Med Chem. 1996 Mar 15;39(6):1193-5. | ||||
| REF 4 | Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent. J Med Chem. 1992 Aug 7;35(16):3081-4. | ||||
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